System design and performance of earth/lunar horizon sensor BEC project 3744

An infrared horizon sensor system has been designed which is capable of searching over a wide field for the edges of a planet and, upon locating such edges, stations itself in a position which provides signals which identify the local vertical to the planet. In this fixed attitude it requires no continuous mechanical movement and operates with a minimum utilization of power. The system is thus capable of providing a high degree of accuracy when used for local vertical determination in orbits around the earth, the moon, or other planets. A detailed description of the design and operating features of the horizon scanner is given and the evaluation test data which have been completed are presented

Excited Heavy Mesons Beyond Leading Order in the Heavy Quark Expansion

We examine the decays of excited heavy mesons, including the leading power corrections to the heavy quark limit. We find a new and natural explanation for the large deviation of the width of the $D_1(2420)$ from the heavy quark symmetry prediction. Our formalism leads to detailed predictions for the properties of the excited bottom mesons, some of which recently have been observed. Finally, we present a detailed analysis of the effect of power corrections and finite meson widths on the angular distributions which may be measured in heavy meson decays.Comment: Uses REVTeX, 19 pages, 6 EPS figures embedded with epsf.st

B Meson Transitions into Higher Mass Charmed Resonances

We use QCD sum rules to estimate the universal form factors describing the semileptonic B decays into excited charmed resonances, such as the $1^-$ and $2^-$ states $D_1^{*}$ and $D_2^{*}$ belonging to the $s_\ell^P={3/2}^-$ heavy quark doublet, and the $2^-$ and $3^-$ states $D_2^{*\prime}$ and $D_3$ belonging to the s_\ell^P={5\2}^- doublet.Comment: LaTex, 14 pages, 1 figur

Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems.

Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointestinal diseases that share inflammation as a key driver for their development. A general outcome resulting from these chronic inflammatory conditions is increased oxidative stress. Oxidative stress is caused by the generation of reactive oxygen and nitrogen species that are part of the normal inflammatory response, but are also capable of damaging cellular DNA, protein, and organelles. Damage to DNA can include DNA strand breaks, point mutations due to DNA adducts, as well as alterations in methylation patterns leading to activation of oncogenes or inactivation of tumor suppressors. There are a number of significant long-term consequences associated with chronic oxidative stress, most notably cancer. Infiltrating immune cells and stromal components of tissue including fibroblasts contribute to dynamic changes occurring in tissue related to disease development. Immune cells can potentiate oxidative stress, and fibroblasts have the capacity to contribute to advanced growth and proliferation of the epithelium and any resultant cancers. Disease models for GERD, BE, GVHD, and ulcerative colitis based on three-dimensional human cell and tissue culture systems that recapitulate in vivo growth and differentiation in inflammatory-associated microphysiological environments would enhance our understanding of disease progression and improve our ability to test for disease-prevention strategies. The development of physiologically relevant, human cell-based culture systems is therefore a major focus of our research. These novel models will be of enormous value, allowing us to test hypotheses and advance our understanding of these disorders, and will have a translational impact allowing us to more rapidly develop therapeutic and chemopreventive agents. In summary, this work to develop advanced human cell-based models of inflammatory conditions will greatly improve our ability to study, prevent, and treat GERD, BE, GVHD, and inflammatory bowel disease. The work will also foster the development of novel therapeutic and preventive strategies that will improve patient care for these important clinical conditions

Higher Order 1/m1/m Corrections at Zero Recoil

The general structure of the $1/m$ corrections at zero recoil is studied. The relevant matrix elements are forward matrix elements of local higher dimensional operators and their time ordered products with higher order terms from the Lagrangian. These matrix elements may be classified in a simple way and the analysis at the non recoil point for the form factor of heavy quark currents simplifies drastically. The second order recoil corrections to the form factor $h_{A1}$ of the axial vector current, relevant for the $|V_{cb}|$ determination from $B \to D^*$ decays, are estimated to be $-5\% < h_{A1} - 1 < 0$.Comment: LaTeX, 25 pages, one figure, appended after \end{document} as uu-encoded and compressed eps file, uses epsf, CERN-TH.7162/9

Retention of mouth-to-mouth, mouth-to-mask and mouth-to-face shield ventilation

Background: Retention of mouth-to-mouth, mouth-to-mask and mouth-to-face shield ventilation techniques is poorly understood.Methods: A prospective randomised clinical trial was undertaken in January 2004 in 70 candidates randomly assigned to training in mouth-to-mouth, mouth-to-mask or mouth-to-face shield ventilation. Each candidate was trained for 10 min, after which tidal volume, respiratory rate, minute volume, peak airway pressure and the presence or absence of stomach inflation were measured. 58 subjects were reassessed 1 year later and study parameters were recorded again. Data were analysed with ANOVA, \textgreekq2 and McNemar tests.Results: Tidal volume, minute volume, peak airway pressure, ventilation rate and stomach inflation rate increased significantly at reassessment with all ventilation techniques compared with the initial assessment. However, at reassessment, mean (SD) tidal volume (960 (446) vs 1008 (366) vs 1402 (302) ml; p<0.05), minute volume (12 (5) vs 13 (7) vs 18 (3) l/min; p<0.05), peak airway pressure (14 (8) vs 17 (13) vs 25 (8) cm H2O; p<0.05) and stomach inflation rate (63% vs 58% vs 100%; p<0.05) were significantly lower with mouth-to-mask and mouth-to-face shield ventilation than with mouth-to-mouth ventilation. The ventilation rate at reassessment did not differ significantly between the ventilation techniques.Conclusions: One year after a single episode of ventilation training, lay persons tended to hyperventilate; however, the degree of hyperventilation and resulting stomach inflation were lower when a mouth-to-mask or a face shield device was employed. Regular training is therefore required to retain ventilation skills; retention of skills may be better with ventilation devices

More on Symmetries in Heavy Quark Effective Theory

We present a general classification of all normal and ``chiral" symmetries of heavy quark effective theories. Some peculiarities and conondrums associated with the ``chiral" symmetries are discussed.Comment: 15 pages, preprint UR-1320, ER40685-77

Strong Decays of Strange Charmed P-Wave Mesons

Goldstone boson decays of P-wave $D_s^{**}$ mesons are studied within the framework of Heavy Hadron Chiral Perturbation Theory. We first analyze the simplest single kaon decays of these strange charmed mesons. We derive a model independent prediction for the width of $D_{s2}$ and use experimental information on $D_{s1}$ to constrain the S-wave contribution to $D_1^0$ decay. Single and double pion decay modes are then discussed and shown to be significantly restricted by isospin conservation. We conclude that the pion channels may offer the best hope for detecting one strange member of an otherwise invisible P-wave flavor multiplet.Comment: 16 pages, 2 updated figures not included but available upon request, CALT-68-1902. (Revised estimates for error on $D_{s2}$ width and for isospin violating neutral pion decay of $D'_{s1}$.

Binary Reactive Adsorbate on a Random Catalytic Substrate

We study the equilibrium properties of a model for a binary mixture of catalytically-reactive monomers adsorbed on a two-dimensional substrate decorated by randomly placed catalytic bonds. The interacting $A$ and $B$ monomer species undergo continuous exchanges with particle reservoirs and react ($A + B \to \emptyset$) as soon as a pair of unlike particles appears on sites connected by a catalytic bond. For the case of annealed disorder in the placement of the catalytic bonds this model can be mapped onto a classical spin model with spin values $S = -1,0,+1$, with effective couplings dependent on the temperature and on the mean density $q$ of catalytic bonds. This allows us to exploit the mean-field theory developed for the latter to determine the phase diagram as a function of $q$ in the (symmetric) case in which the chemical potentials of the particle reservoirs, as well as the $A-A$ and $B-B$ interactions are equal.Comment: 12 pages, 4 figure

Lymphoepithelial Cyst of the Pancreas: Serum Markers do not Help

We report a case of lymphoepithelial cyst of the pancreas with non-specific elevation of CA 19.9 and CEA. Pre-operative diagnosis by conventional means proved elusive, and only surgical resection and histopathology revealed the diagnosis. The origin and diagnosis are discussed by literature review