Relevance of d-D interactions on neutron and tritium production in IFMIF-EVEDA accelerator prototype

In the IFMIF-EVEDA accelerator prototype, deuterium is implanted in the components due to beam losses and in the beam dump, where the beam is stopped. The interaction of the deuterons with the deuterium previously implanted leads to the production of neutrons and tritium, which are important issues for radioprotection and safety analysis. A methodology to assess these production pathways in more realistic approach has been developed. The new tools and their main achievement are: (i) an “effective diffusivity coefficient” (deduced from available experimental data) that enables simulation of the diffusion phase, and (ii) the MCUNED code (able to handle deuteron transport libraries) allows to simulate the transport-slowdown of deuteron/tritium (to get the concentration profiles) and the neutron/tritium productions from d-Cu and d-D for up to 9 MeV incident deuteron. The results with/without theses tools are presented and their effect on the relevance of d-D sources versus d-Cu is evaluated

Alterations of glucose metabolism indexes in hypertension

Proceedings of the Chicago 2000 World Congress on Medical Physics and Biomedical Engineering, Chicago, I

Morphological alterations and increased resistance to hemolysis in t-butyl hydroperoxide incubated RBC from elderly subjects

The response of human red blood cells (RBC) to oxidative stress has been studied with the aim to evaluate any difference in the behavior of cells from young and old subjects. Thus, RBC from 5 young (27 +/- 2 years) and 5 old (80 +/- 5 years) individuals have been treated with the organic peroxide t-butyl hydroperoxide (TBHP). The two groups behaved differently: after 4 hrs of incubation in 0.5 mM TBHP, RBC from young donors showed a higher level of hemolysis; instead, RBC from old individuals showed abnormal morphologies, being absent in unstressed RBC, with constriction and budding, which could be identified as poikilocytosis. The same abnormal forms are found in patients with spectrin mutation, leading us to hypothesize that TBHP causes damage to the cytoskeletal spectrin. This suggests that poikilocytosis might be an early stage of red blood cell hemolysis because their presence is associated to a lower level of hemolysis