Molekulare Veränderungen beim Pankreaskarzinom

Zusammenfassung: Grundlagen: Das Pankreaskarzinom hat eine infauste Prognose. Die Ursachen für das aggressive Tumorwachstum und die frühe Metastasierung sind nur unzureichend bekannt. Mit Hilfe von modernen molekularbiologischen Untersuchungstechniken ist es in den vergangenen Jahren gelungen, einen Einblick in die Pathophysiologie dieser Erkrankung zu gewinnen. Methodik: Im Rahmen dieser Übersicht wird die pathogenetische Bedeutung von Wachstumsfaktor-Rezeptoren (EGFR, c-erbB-2, c-erbB-3), Wachstumsfaktoren (EGF, TGF-α, Amphiregulin, Betacellulin, TGF-βs, FGFs) sowie von Genmutationen (p53, K-ras) und Adhäsionsmolekülen beim humanen Pankreaskarzinom dargestellt. Ergebnisse: In einer signifikanten Anzahl der Pankreaskarzinome sind Wachstumsfaktorrezeptoren (EGFR, c-erbB-2, c-erbB-3), Wachstumsfaktoren (EGF, TGF-α, Amphiregulin, Betacellulin, TGF-βs, FGFs) und Adhäsionsmoleküle (ICAM-1, ELAM-1) überexprimiert sowie Genmutationen (p53, K-ras) vorhanden. Allerdings sind nicht alle diese molekularen Veränderungen mit einem schnelleren Tumorwachstum und einer schlechteren Prognose nach Tumorresektion vergesellschaftet. Schlußfolgerungen: Molekulare Störungen in Pankreaskarzinomzellen tragen zum malignen Phänotyp bei. Diese Veränderungen erklären, warum die Pankreaskarzinomzellen schnell proliferieren und nur eine geringe Ansprechbarkeit auf adjuvante onkologische Behandlungen zeige

Zinc Gluconate in the Treatment of Dysgeusia—a Randomized Clinical Trial

In the treatment of dysgeusia, the use of zinc has been frequently tried, with equivocal results. The aim of the present randomized clinical trial, which involved a sufficiently large sample, was therefore to determine the efficacy of zinc treatment. Fifty patients with idiopathic dysgeusia were carefully selected. Zinc gluconate (140 mg/day; n = 26) or placebo (lactose; n = 24) was randomly assigned to the patients. The patients on zinc improved in terms of gustatory function (p < 0.001) and rated the dysgeusia as being less severe (p < 0.05). Similarly, signs of depression in the zinc group were less severe (Beck Depression Inventory, p < 0.05; mood scale, p < 0.05). With the exception of the salivary calcium level, which was higher in the zinc patients (p < 0.05), no other significant group differences were found. In conclusion, zinc appears to improve general gustatory function and, consequently, general mood scores in dysgeusia patients

Ancient high-energy storm boulder deposits on Ko Samui, Thailand, and their significance for identifying coastal hazard risk

© 2016 Elsevier B.V. Coastal geomorphic processes associated with high-energy storm events are difficult to estimate over recent geological history, though their frequency and magnitude are important to assess in order to understand present-day coastal vulnerability. Studying ancient coastal boulder deposits can shed light on the previous physical conditions necessary for their deposition. In this study, we estimated the physical processes required to move reef-derived coral boulders on the east coast of Ko Samui, a rapidly developing tourist island off eastern peninsular Thailand. The position and dimensions of 97 coral boulders (weight: mean 2.9. t, max. 12.7. t; transport distance: max. 125. m) were measured at two sites and dated using uranium/thorium methods. Flow velocities of 2.3-8.6. m/s were required to transport the measured boulders, with individuals deposited up to 4.7. m above mean sea level. Age-dating suggests that events capable of the highest flow velocities occurred around AD 1600 and AD 1750. These were probably driven by tropical cyclones (typhoons). Boulder transport by events of similar magnitude has not been detected within the last 250. years. The non-occurrence of similar events in living memory has implications for hazard perceptions at this important tourist destination. However, there is also evidence of substantial Holocene sea-level changes in the Gulf of Thailand, as observed at nearby Ko Phaluai. This potentially offers a challenge for the interpretation of older boulders dating from the mid-Holocene, as sea level may have been more than 2. m higher than present. Thus, studies using coral boulders as a proxy for past storm-wave conditions must consider the broader sea-level history, and are probably best limited to the period post-2000. BP in the Gulf of Thailand

Stability of strings binding heavy-quark mesons

We investigate the stability against small deformations of strings dangling into AdS_5-Schwarzschild from a moving heavy quark-anti-quark pair. We speculate that emission of massive string states may be an important part of the evolution of certain unstable configurations.Comment: 14 pages, 4 figure

No-Drag String Configurations for Steadily Moving Quark-Antiquark Pairs in a Thermal Bath

We investigate the behavior of stationary string configurations on a five-dimensional AdS black hole background which correspond to quark-antiquark pairs steadily moving in an N=4 super Yang-Mills thermal bath. There are many branches of solutions, depending on the quark velocity and separation as well as on whether Euclidean or Lorentzian configurations are examined.Comment: references added; statements corrected; eliminated computation of jet quenching parameter from Wilson loop of [Liu, Rajagopal, Wiedemann, hep-th/0605178] using Euclidean string configurations since those authors advocate [hep-th/0607062, footnote 14] the use of spacelike Lorentzian string configurations instea

Drag Force in a Charged N=4 SYM Plasma

Following recent developments, we employ the AdS/CFT correspondence to determine the drag force exerted on an external quark that moves through an N=4 super-Yang-Mills plasma with a non-zero R-charge density (or, equivalently, a non-zero chemical potential). We find that the drag force is larger than in the case where the plasma is neutral, but the dependence on the charge is non-monotonic.Comment: 16 pages, 1 eps figure; v2: references added, typos fixed; v3: more general ansatz, new nontrivial solution obtained, nonmonotonicity of the drag force made explicit in new figure, version to appear in JHE

The Gregory-Laflamme instability for the D2-D0 bound state

The D2-D0 bound state exhibits a Gregory-Laflamme instability when it is sufficiently non-extremal. If there are no D0-branes, the requisite non-extremality is finite. When most of the extremal mass comes from D0-branes, the requisite non-extremality is very small. The location of the threshhold for the instability is determined using a local thermodynamic analysis which is then checked against a numerical analysis of the linearized equations of motion. The thermodynamic analysis reveals an instability of non-commutative field theory at finite temperature, which may occur only at very long wavelengths as the decoupling limit is approached.Comment: 19 pages, Latex2e. v2: two refs added. v3: clearer exposition in section

Heavy flavor diffusion in weakly coupled N=4 Super Yang-Mills theory

We use perturbation theory to compute the diffusion coefficient of a heavy quark or scalar moving in N=4 SU(N_c) Super Yang-Mills plasma to leading order in the coupling and the ratio T/M<<1. The result is compared both to recent strong coupling calculations in the same theory and to the corresponding weak coupling result in QCD. Finally, we present a compact and simple formulation of the Lagrangian of our theory, N=4 SYM coupled to a massive fundamental N=2 hypermultiplet, which is well-suited for weak coupling expansions.Comment: 22 pages, 4 figures; v3: error corrected in calculations, figures and discussion modified accordingl

Energy Loss of Gluons, Baryons and k-Quarks in an N=4 SYM Plasma

We consider different types of external color sources that move through a strongly-coupled thermal N=4 super-Yang-Mills plasma, and calculate, via the AdS/CFT correspondence, the dissipative force (or equivalently, the rate of energy loss) they experience. A bound state of k quarks in the totally antisymmetric representation is found to feel a force with a nontrivial k-dependence. Our result for k=1 (or k=N-1) agrees at large N with the one obtained recently by Herzog et al. and Gubser, but contains in addition an infinite series of 1/N corrections. The baryon (k=N) is seen to experience no drag. Finally, a heavy gluon is found to be subject to a force which at large N is twice as large as the one experienced by a heavy quark, in accordance with gauge theory expectations.Comment: Latex 2e, 24 pages, 1 eps figure; v2: slightly amplified discussion on the relation between the drag force and the tension of a spatial Wilson loop; v3: minor changes, version to appear in JHE

Drag force in SYM plasma with B field from AdS/CFT

We investigate drag force in a thermal plasma of N=4 super Yang-Mills theory via both fundamental and Dirichlet strings under the influence of non-zero NSNS $B$-field background. In the description of AdS/CFT correspondence the endpoint of these strings correspondes to an external monopole or quark moving with a constant electromagnetic field. We demonstrate how the configuration of string tail as well as the drag force obtains corrections in this background.Comment: 13 pages, 2 figures, more discussion and reference adde