Primary care physicians' knowledge and attitudes towards genetic testing for breast-ovarian cancer predisposition

Background: Primary health care providers are expected to be directly involved in the genetic testing for cancer susceptibility. This study assessed physicians' knowledge, attitude and perception of their role towards testing for hereditary breast-ovarian cancer. Design: A mail-in survey was sent to all general practitioners, internists, obstetrician-gynecologists and oncologists in private practice in Geneva county, Switzerland. Questions included socio-demographic variables, knowledge about hereditary breast-ovarian cancer, attitude towards testing and assessment of their role in the pre- and post-test procedure. Results: Two hundred fifty-nine (65%) of four hundred questionnaires were returned of which two hundred forty-three (61%) were analysed. Response rates were similar between specialties; women answered more frequently. The majority of the respondents (87%) approved of genetic susceptibility testing. The most common objection to testing was the absence of approved strategies for the prevention and detection of early breast cancer. Most physicians felt they had an active part to play in the pre-test procedure, the disclosure of results, and especially the consultants' long-term care and support (99%). Physicians correctly answered a third (32%) of the knowledge questions. The abstention rate for individual items ranged from 13% to 60%. Scores varied by specialty. Oncologists were more knowledgeable than gynecologists, internists and general practitioners. Conclusions: The majority of the primary care physicians in this study have a favourable attitude and are ready to play a prominent role in genetic counseling and testing for breast-ovarian cancer predisposition. Defective knowledge scores, however, underline the need for targeted educational program

The Swiss Federal Institute of Intellectual Property

The Swiss Federal Institute of Intellectual Property is the granting authority for all intellectual property rights in Switzerland. These include national patents, trademarks and designs. Apart from these official duties, it offers a broad spectrum of services, like assistance for patent applicants, training courses about intellectual property as well as a series of patent and technical information services. By these means the Institute supports the protection of the research results as well as the progress of the Swiss industry and science

Patent Information on the Internet

Many people believe that the entire world's information is somehow accessible on the Internet and costs virtually nothing to retrieve. Others view the Internet as a slow, overrated mechanism for obtaining information that may or may not be reliable. For the information specialist, the Internet has become another useful resource for obtaining information. This article is an attempt to provide an overview of free and commercial sites containing patent databases and to outline the possibilities as well as the limitations of these patent information sources. In addition to this written article, we have set up a Web site (http://chemsear.ch/chimia/) which contains all the important links as well as additional information about patents on the Internet

The geometry of a vorticity model equation

We provide rigorous evidence of the fact that the modified Constantin-Lax-Majda equation modeling vortex and quasi-geostrophic dynamics describes the geodesic flow on the subgroup of orientation-preserving diffeomorphisms fixing one point, with respect to right-invariant metric induced by the homogeneous Sobolev norm $H^{1/2}$ and show the local existence of the geodesics in the extended group of diffeomorphisms of Sobolev class $H^{k}$ with $k\ge 2$.Comment: 24 page

Reaction cross-section predictions for nucleon induced reactions

A microscopic calculation of the optical potential for nucleon-nucleus scattering has been performed by explicitly coupling the elastic channel to all the particle-hole (p-h) excitation states in the target and to all relevant pickup channels. These p-h states may be regarded as doorway states through which the flux flows to more complicated configurations, and to long-lived compound nucleus resonances. We calculated the reaction cross sections for the nucleon induced reactions on the targets $^{40,48}$Ca, $^{58}$Ni, $^{90}$Zr and $^{144}$Sm using the QRPA description of target excitations, coupling to all inelastic open channels, and coupling to all transfer channels corresponding to the formation of a deuteron. The results of such calculations were compared to predictions of a well-established optical potential and with experimental data, reaching very good agreement. The inclusion of couplings to pickup channels were an important contribution to the absorption. For the first time, calculations of excitations account for all of the observed reaction cross-sections, at least for incident energies above 10 MeV.Comment: 6 pages, 6 figures. Submitted to INPC 2010 Conference Proceeding

The curvature of semidirect product groups associated with two-component Hunter-Saxton systems

In this paper, we study two-component versions of the periodic Hunter-Saxton equation and its $\mu$-variant. Considering both equations as a geodesic flow on the semidirect product of the circle diffeomorphism group \Diff(\S) with a space of scalar functions on $\S$ we show that both equations are locally well-posed. The main result of the paper is that the sectional curvature associated with the 2HS is constant and positive and that 2$\mu$HS allows for a large subspace of positive sectional curvature. The issues of this paper are related to some of the results for 2CH and 2DP presented in [J. Escher, M. Kohlmann, and J. Lenells, J. Geom. Phys. 61 (2011), 436-452].Comment: 19 page

Right-invariant Sobolev metrics of fractional order on the diffeomorphism group of the circle

In this paper, we study the geodesic flow of a right-invariant metric induced by a general Fourier multiplier on the diffeomorphism group of the circle and on some of its homogeneous spaces. This study covers in particular right-invariant metrics induced by Sobolev norms of fractional order. We show that, under a certain condition on the symbol of the inertia operator (which is satisfied for the fractional Sobolev norm $H^{s}$ for $s \ge 1/2$), the corresponding initial value problem is well-posed in the smooth category and that the Riemannian exponential map is a smooth local diffeomorphism. Paradigmatic examples of our general setting cover, besides all traditional Euler equations induced by a local inertia operator, the Constantin-Lax-Majda equation, and the Euler-Weil-Petersson equation.Comment: 40 pages. Corrected typos and improved redactio