Safety & efficacy of lifileucel (LN-144) tumor infiltrating lymphocyte therapy in metastatic melanoma patients after progression on multiple therapies – independent review committee data update

Treatment options are limited for patients with advanced melanoma who have progressed on checkpoint inhibitors and targeted therapies such as BRAF/MEK inhibitors (if BRAF-V600E mutated). Adoptive cell therapy utilizing tumor-infiltrating lymphocytes (TIL) has shown antitumor efficacy with durable responses in heavily pretreated melanoma patients. Safety and efficacy of lifileucel, a centrally manufactured cryopreserved autologous TIL therapy assessed by both investigator and an independent review committee (IRC), are presented

On conditions of solvability of combinatorial multicriteria optimization by linear convolution of criteria

In the paper we investigate the possibility of finding the Pareto set in combinatorial multicriteria optimization problems with a finite criterion-valued set. We found conditions under which this problem is solvable by a linear convolution of criteria (LCC-solvable). i.e. each Pareto optimum of the problem may be got as an optimal solution in the parametric problem with one aggregative criterion. We also propose an algorithm allowing to resume any combinatorical multicriteria optimization problem to a problem with the same Pareto set, but LCC-solvable. (orig.)Available from TIB Hannover: RR 4487(1996,26) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Self-phase matching and X pulse formation in phase-mismatched second harmonic generation due to dimensionality transition

Since 1961, when Franken and his collaborators experimentally discovered second-harmonic generation (SHG) [1], the process of SHG has been widely investigated leading first to important contributions by many authors, who derived the now well-known theory described in nonlinear optics books. It was realized long time ago that the use of short light pulses for SHG gives rise to special effects, like the broadening of the generated light pulse due to the group velocity mismatch between the fundamental (FH) and second-harmonic (SH) pulses, predicted by Comly and coworkers [2] and observed for the first time by Shapiro [3]. Typically SHG is investigated or used at or near the phase-matching condition, in such a way to maximize the conversion efficiency. More recently the study of propagation phenomena in phase-mismatched second-harmonic processes has attracted considerable interest, in particular for the investigation of the effect on the generated pulse shape. However, typically mentioned studies were done in the case when the plane wave approximation is valid and SHG could be recognized as one-dimensional problem. © 2011 IEEE

Quantum imaging and the detection of weak objects

A recent experiment has demonstrated the quantum nature of spatial fluctuations in parametric down-conversion. We show theoretically and numerically that, by exploiting the sub-shot-noise character of spatial correlations, it is possible to detect weak amplitude objects with a sensitivity beyond the standard quantum limit

Exploring the spatio-temporal correlation of twin photons via frequency up-conversion

The entangled photon pairs (biphotons) produced from parametric down-conversion (PDC) in a (2) crystal are the key element for several quantum information and communication schemes. Recent theoretical investigations [1-2] have revealed the peculiar structure of the biphotonic correlation characterizing the entanglement of twin beams in the space-time domain. The biphotonic correlation in type I PDC is characterized in the near field by a X-shaped geometry, which turns out to be non-factorable in space and time, offering thus the relevant possibility of manipulating the temporal bandwidth of biphoton entanglement by acting on their spatial degrees of freedom. The name X-entanglement was coined to describe this geometry [1]. An other key feature which emerged is the extreme spatial and temporal localization of the biphotonic correlation, on the micrometer and femtosecond range, respectively. \ua9 2011 IEEE

Controllable patterns of parametric solitons

Peer ReviewedPostprint (published version

PROSTATITIS, PROSTATOSIS AND PROSTALGIA - PSYCHOGENIC OR ORGANIC-DISEASE

The term 'chronic prostatitis syndrome' (C.P.S) encompasses chronic bacterial prostatitis, chlamydia or ureaplasma-associated disease, chronic 'abacterial' prostatitis, and patients with prostatosis or prostatosis or prostalgia. Interesting observations emerged from the evaluation of the clinical material indicating that the patients with abacterial prostatitis and those with prostatosis or prostaglia group have frequent sperm abnormalities and ultrasonographic changes suggesting a more complex pathogenesis than mere congestion and neurosis. Treatment in 144 evaluable patients treated with a long-acting sulphur-trimethoprim combination was almost uniformly well tolerated; Chlamydia was eradicated in all 10 treated patients and 77.4% of patients with bacterial C.P.S. were rendered free of bacteria. Sperm abnormalities were almost invariably resistant to the treatment. Only 44.4% of patients showed a partial improvement, limited to one or more parameters. Results did not differ significantly in the various subgroup. An overall evaluation of results showed that disappearance of every presenting symptom and sign was obtained in 24.3% and a significant improvement in another 25% of patients, including those in the prostatosis-prostalgia group. These results suggest that antibacterial treatment may be followed by favourable clinical results even in patients in whom no bacteria or other aetiological agents could be isolated