Qing China and the Legal Treatment of Mental Infirmity: A Preliminary Sketch in Tribute to Professor William C. Jones

This short tribute to Professor Jones aspires toward the high standard he continues to set as it reports briefly on research being conducted into the legal treatment of madness in late imperial China. As the work of Michel Foucault, among others, has demonstrated, an inquiry into definitions, legal and otherwise, of insanity and the treatment thereof is revealing not only about its immediate subject matter, but as well for what it suggests about that which a society understands to be normal behavior. Notwithstanding the brilliant work by Arthur Kleinman on mental illness in Chinese society, and the alarming reports by Robin Munro on the abusive use of psychiatric confinement in the People’s Republic of China, there is, however, surprisingly little written, whether by Chinese or Western scholars, regarding the legal construction of insanity in China

Structural Analysis of the Voltage-Dependent Calcium Channel β Subunit Functional Core and Its Complex with the α1 Interaction Domain

AbstractVoltage-dependent calcium channels (VDCC) are multiprotein assemblies that regulate the entry of extracellular calcium into electrically excitable cells and serve as signal transduction centers. The α1 subunit forms the membrane pore while the intracellular β subunit is responsible for trafficking of the channel to the plasma membrane and modulation of its electrophysiological properties. Crystallographic analyses of a β subunit functional core alone and in complex with a α1 interaction domain (AID) peptide, the primary binding site of β to the α1 subunit, reveal that β represents a novel member of the MAGUK protein family. The findings illustrate how the guanylate kinase fold has been fashioned into a protein-protein interaction module by alteration of one of its substrate sites. Combined results indicate that the AID peptide undergoes a helical transition in binding to β. We outline the mechanistic implications for understanding the β subunit's broad regulatory role of the VDCC, particularly via the AID

Divergence and Shannon information in genomes

Shannon information (SI) and its special case, divergence, are defined for a DNA sequence in terms of probabilities of chemical words in the sequence and are computed for a set of complete genomes highly diverse in length and composition. We find the following: SI (but not divergence) is inversely proportional to sequence length for a random sequence but is length-independent for genomes; the genomic SI is always greater and, for shorter words and longer sequences, hundreds to thousands times greater than the SI in a random sequence whose length and composition match those of the genome; genomic SIs appear to have word-length dependent universal values. The universality is inferred to be an evolution footprint of a universal mode for genome growth.Comment: 4 pages, 3 tables, 2 figure

Draft genome sequence of Aeromonas caviae strain L12, a quorum-sensing strain isolated from a freshwater lake in Malaysia

YesHere, we present the draft genome sequence of Aeromonas caviae strain L12, which shows quorum-sensing activity. The availability of this genome sequence is important to the research of the quorum-sensing regulatory system in this isolate.High Impact Research Grants from the University of Malaya (A000001-50001; UM-MOHE HIR Grant UM C/625/1/HIR/MOHE/CHAN/14/1, H-50001-A000027

High pressure evolution of Fe2_{2}O3_{3} electronic structure revealed by X-ray absorption

We report the first high pressure measurement of the Fe K-edge in hematite (Fe$_2$O$_3$) by X-ray absorption spectroscopy in partial fluorescence yield geometry. The pressure-induced evolution of the electronic structure as Fe$_2$O$_3$ transforms from a high-spin insulator to a low-spin metal is reflected in the x-ray absorption pre-edge. The crystal field splitting energy was found to increase monotonically with pressure up to 48 GPa, above which a series of phase transitions occur. Atomic multiplet, cluster diagonalization, and density-functional calculations were performed to simulate the pre-edge absorption spectra, showing good qualitative agreement with the measurements. The mechanism for the pressure-induced phase transitions of Fe$_2$O$_3$ is discussed and it is shown that ligand hybridization significantly reduces the critical high-spin/low-spin pressure.Comment: 5 pages, 4 figures and 1 tabl

Influence of shear flow on vesicles near a wall: a numerical study

We describe the dynamics of three-dimensional fluid vesicles in steady shear flow in the vicinity of a wall. This is analyzed numerically at low Reynolds numbers using a boundary element method. The area-incompressible vesicle exhibits bending elasticity. Forces due to adhesion or gravity oppose the hydrodynamic lift force driving the vesicle away from a wall. We investigate three cases. First, a neutrally buoyant vesicle is placed in the vicinity of a wall which acts only as a geometrical constraint. We find that the lift velocity is linearly proportional to shear rate and decreases with increasing distance between the vesicle and the wall. Second, with a vesicle filled with a denser fluid, we find a stationary hovering state. We present an estimate of the viscous lift force which seems to agree with recent experiments of Lorz et al. [Europhys. Lett., vol. 51, 468 (2000)]. Third, if the wall exerts an additional adhesive force, we investigate the dynamical unbinding transition which occurs at an adhesion strength linearly proportional to the shear rate.Comment: 17 pages (incl. 10 figures), RevTeX (figures in PostScript

Gossip in the workplace and the implications for HR management : a study of gossip and its relationship to employee cynicism

Gossip is a common phenomenon in the workplace and yet relatively little is understood about its influence to employees. This study adopts social information theory and social cognitive theory to interpret the diverse literature on gossip, and to develop and test hypotheses concerning some of the antecedents of gossip, with an aim of developing knowledge of the relationship between gossip and employee behaviour in the workplace. The study analysed survey data in a two stage process, from 362 employees across a range of industries in Taiwan. The findings revealed that job-related gossip predicted employee cynicism and mediated the relationship between psychological contract violation and cynicism, and that non-job-related gossip showed a similar but weaker effect to employee cynicism. The contribution made by this paper is of value to both the academic subject domain and managers in Human Resources. Firstly, we have identified two constructs of gossip, job related and non-job related gossip not previously reported and a validated scale has been created. Secondly, we have confirmed that these different constructs of gossip impact differently on employee behaviour and therefore HR managers should be cautious about gossip in the workplace, as it can cause cynical behaviour amongst employees

Covariant Light-Front Approach for s-wave and p-wave Mesons: Its Application to Decay Constants and Form Factors

We study the decay constants and form factors of the ground-state s-wave and low-lying p-wave mesons within a covariant light-front approach. Numerical results of the form factors for transitions between a heavy pseudoscalar meson and an s-wave or p-wave meson and their momentum dependence are presented in detail. In particular, form factors for heavy-to-light and B to D** transitions, where D** denotes generically a p-wave charmed meson, are compared with other model calculations. The experimental measurements of the decays B^- to D** pi^- and B to D D**_s are employed to test the decay constants of D**_s and the B to D** transition form factors. The heavy quark limit behavior of the decay constants and form factors is examined and it is found that the requirement of heavy quark symmetry is satisfied. The universal Isgur-Wise (IW) functions, one for s-wave to s-wave and two for s-wave to p-wave transitions, are obtained. The values of IW functions at zero recoil and their slope parameters can be used to test the Bjorken and Uraltsev sum rules.Comment: 59 pages, 6 figures. Version to appear in Phys. Rev. D. Changes are: (i) D_s to phi transition form factors are discussed and compared with the recent FOCUS measurements and (ii) zero mode effects are clarifie

Synthesis and characterization of new fluorescent two-photon absorption chromophores{

A series of dipolar and quadrupolar type two-photon absorption (TPA) compounds has been synthesized and TPA cross sections (s) were measured by Ti:sapphire femtosecond laser excitation fluorescence (l = 800 nm). Among them, the compound ) can be achieved. One quadrupolar molecule (13) possessing an arylamine donor and a pyridazine acceptor has both a high s value (1442 GM) and s/MW (1.97 GM/g)