Electron-Neutrino Bremsstrahlung in Electro-Weak Theory

The electron-neutrino bremsstrahlung process has been considered in the framework of electro-weak theory. The scattering cross section has been calculated in the center of mass frame and approximated to extreme relativistic as well as non-relativistic case. The rate of energy-loss via this type of bremsstrahlung process has been obtained both in non-degenerate and degenerate region. The effect of this electron-neutrino bremsstrahlung process in different ranges of temperature and density characterizing the late stages of stellar evolution has been discussed. It is found from our study that this bremsstrahlung process is highly important in the non-degenerate region, although it might have some significant effect in the extreme relativistic degenerate region.Comment: 18 pages including 4 figures and 1 table; Published in J. Phys

Bremsstrahlung neutrinos from electron-electron scattering in a relativistic degenerate electron plasma

We present a calculation of neutrino pair bremsstrahlung due to electron-electron scattering in a relativistic degenerate plasma of electrons. Proper treatment of the in-medium photon propagator, i.e., inclusion of Debye screening of the longitudinal part and Landau damping of the transverse part, leads to a neutrino emissivity which is several orders of magnitude larger than when Debye screening is imposed for the tranverse part. Our results show that this in-medium process can compete with other sources of neutrino radiation and can, in some cases, even be the dominant neutrino emission mechanism. We also discuss the natural extension to quark-quark bremsstrahlung in gapped and ungapped quark matter.Comment: 15 pages, 7 figure

Pharmacological management of COVID-19 patients with ARDS (CARDS): A narrative review

Coronavirus disease 2019 (COVID-19) is highly infectious. It has been highlighted that if not expertly and individually managed with consideration of the vasocentric features, a COVID-19 patient with an acute respiratory distress syndrome (CARDS) may eventually develop multiorgan failure. Unfortunately, there is still no definite drug for CARDS that is capable of reducing either short-term or long-term mortality and no specific treatments for COVID-19 exist right now. In this narrative review, based on a selective literature search in EMBASE, MEDLINE, Scopus, The Cochrane Library, Web of Science, and Google Scholar and ClinicalTrials.gov, we have examined the emerging evidence on the possible treatment of CARDS. Although numerous pharmacologic therapies to improve clinical outcomes in CARDS have been studied also in clinical trials, none have shown efficacy and there is great uncertainty about their effectiveness. There is still no recommendation for the therapeutic use of any specific agent to treat CARDS because no drugs are validated to have significant efficacy in clinical treatment of COVID-19 patients in large-scale trials. However, there exist a number of drugs that may be useful at least in some patients. The real challenge now is to link the right patient to the right treatment

Summary of International Transport Energy Modeling Workshop

The NextSTEPS program at ITS-Davis convened a one-day workshop on international transportation energy modeling (iTEM), focused on comparing the frameworks and scenario projections from four major global transport models: -- Global Change Assessment Model (GCAM) by Pacific Northwest National Laboratory (PNNL) and ITS-Davis, -- MESSAGE-Transport (Model for Energy Supply Strategy Alternatives and their General Environmental Impact) by the International Institute for Applied Systems Analysis (IIASA), -- Mobility Model (MoMo) by the International Energy Agency, and -- Roadmap by the International Council on Clean Transportation (ICCT). Highlights: -- Projections of "baseline" global transportation energy use rise from 98 EJ in 2010 to 160-250 EJ by 2050. -- There are considerable differences in historical data for some modes, both globally and for individual countries (particularly non-OECD countries). Variability in estimates of transportation activity are in most cases much larger than energy differences. -- Global average vehicle ownership rates are projected to range from 270 to 450 per 1,000 people by 2050 with wide ranges across countries: 700-1,075 for the US by the middle of the century (US is around 700 today), 100-650 for China, and 80-380 for India across four models. -- All models rely mainly on GDP to estimate the future demand for freight and hold the base year modal shares (e.g. truck v. rail) roughly constant through 2050. In reality, future evolution will depend on characteristics of products (e.g. type of commodities) being shipped, technologies available for freight and their efficiencies, and policies and infrastructure. -- Current policy commitments toward EVs, PHEVs and H2FCVs (and thus baseline projections) maybe below the numbers suggested by iTEM models as required for meeting climate targets (e.g., 2 degrees C). -- Improvements in data quality and the representation of car ownership and use across the models were identified as priorities. Modeling transport energy use can either be done by estimating how far people travel and what mode of transportation they choose or by estimating how many vehicles there are and how far each one travels. These are complementary approaches, and in theory they should both lead to the same answer. The former approach, used in "service demand" models, seem more intuitive when one wants to model societal shifts in modes of transportation, either in emerging economies as they develop or in developed economies as they decarbonize; but collecting data on service demand is notoriously difficult. In contrast, vehicle stock models use readily-available vehicle sales data, but are harder to use in future-state, what-if scenarios (particularly in estimating modal shift behaviors) and thus require special attention by experts. The four iTEM models are different in terms of scope (GCAM and MESSAGE cover all sectors of the energy system vs. MoMo and Roadmap which cover transportation only) and model structure (GCAM and MESSAGE rely on internal drivers, particularly the costs of technology and travel, to project future changes whereas MoMo and Roadmap rely on experts' judgments and detailed analysis of technology and policies to drive long-term changes). Yet, owing to these differences, the models are highly complementary and in some cases can be used jointly to answer questions that no single model can tackle on its own. The following summary shares some of the comparisons and findings from the workshop

Effect of formoterol/budesonide combination on arterial blood gases in patients with acute exacerbation of COPD

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SPINAL MUSCLE ACTIVITY DURING DIFFERENT RUGBY SCRUM ENGAGEMENT PROCEDURES

Biomechanical studies of rugby union scrummaging have focussed on kinetic and kinematic analyses, whilst muscle activation strategies employed by front row players during scrummaging are still unknown. The aim of this study was to investigate the activity of the sternocleidomastoid, upper trapezius and erector spinae muscles during machine and live scrums. Nine male front-row forwards scrummaged individually against a scrum machine under „crouch-touch-set? and „crouch-bind-set? conditions, and against a two-player opposition in a simulated live condition. Results suggest that the pre-bind technique, may effectively prepare the cervical spine by stiffening joints before the impact phase. Additionally, machine scrummaging does not replicate the muscular demands of live scrummaging for the erector spinae

Red blood cell precursor mass as an independent determinant of serum erythropoietin level.

Serum erythropoietin (sEpo) concentration is primarily related to the rate of renal production and, under the stimulus of hypoxia, increases exponentially as hemoglobin (Hb) decreases. Additional factors, however, appear to influence sEpo, and in this work, we performed studies to evaluate the role of the red blood cell precursor mass. We first compared the relationship of sEpo with Hb in patients with low versus high erythroid activity. The first group included 27 patients with erythroid aplasia or hypoplasia having serum transferrin receptor (sTfR) levels 10 mg/L (erythroid activity > 2 times normal). There was no difference between the two groups with respect to Hb (8.3 +/- 1.6 v 8.0 +/- 1.3 g/dL, P > .05), but sEpo levels were notably higher in patients with low erythroid activity (1,601 +/- 1,542 v 235 +/- 143 mU/mL, P < . 001). In fact, multivariate analysis of variance (ANOVA) showed that, at any given Hb level, sEpo was higher in patients with low erythroid activity (P < .0001). Twenty patients undergoing allogeneic or autologous bone marrow transplantation (BMT) were then investigated. A marked increase in sEpo was seen in all cases at the time of marrow aplasia, disproportionately high when compared with the small decrease in Hb level. Sequential studies were also performed in five patients with iron deficiency anemia undergoing intravenous (IV) iron therapy. Within 24 to 72 hours after starting iron treatment, marked decreases in sEpo (up to one log magnitude) were found before any change in Hb level. Similar observations were made in patients with megaloblastic anemia and in a case of pure red blood cell aplasia. These findings point to an inverse relationship between red blood cell precursor mass and sEpo: at any given Hb level, the higher the number of red blood cell precursors, the lower the sEpo concentration. The most likely explanation for this is that sEpo levels are regulated not only by the rate of renal production, but also by the rate of utilization by erythroid cells

Mutational analysis of BCORL1 in the leukemic transformation of chronic myeloproliferative neoplasms.

BCORL1 mutations do not seem to be commonly associated with leukemic transformation of MPN, further substantiating the different molecular profile compared with denovo leukemias. Although the small number of cases does not allow us to exclude that BCORL1 mutations can be found also in post-MPN AML, their occurrence is, at least, very infrequent and their detection does not appear to deserve clinical relevance

Three-dimensional morphological condylar and mandibular changes in a patient with juvenile idiopathic arthritis: Interdisciplinary treatment

Temporomandibular joint (TMJ) involvement is common but usually delayed in patients with juvenile idiopathic arthritis (JIA). We describe the case of a JIA patient with bilateral TMJ involvement, mandibular retrognathia, bone erosion, and severely restricted mouth opening. The use of cone beam computed tomography and a 3D diagnostic protocol in young patients with JIA provides reliable, accurate and precise quantitative data and images of the condylar structures and their dimensional relationships. Analgesics and conventional disease modifying antirheumatic drugs were ineffective, but interdisciplinary treatment with etanercept and a Herbst functional appliance improved functional TMJ movement and bone resorption

Musculoskeletal modelling of the human cervical spine for the investigation of injury mechanisms during axial impacts

This is the final version. Available from Public Library of Science via the DOI in this record.All relevant data are available at Figshare [https://figshare.com/projects/SILVESTROS_PLOS_ONE_SUPPORTING_DOCUMENTS/58280] and musculoskeletal models and relevant project information is available on the OpenSim SimTK repository [https://simtk.org/projects/csibath].Head collisions in sport can result in catastrophic injuries to the cervical spine. Musculoskeletal modelling can help analyse the relationship between motion, external forces and internal loads that lead to injury. However, impact specific musculoskeletal models are lacking as current viscoelastic values used to describe cervical spine joint dynamics have been obtained from unrepresentative quasi-static or static experiments. The aim of this study was to develop and validate a cervical spine musculoskeletal model for use in axial impacts. Cervical spine specimens (C2-C6) were tested under measured sub-catastrophic loads and the resulting 3D motion of the vertebrae was measured. Specimen specific musculoskeletal models were then created and used to estimate the axial and shear viscoelastic (stiffness and damping) properties of the joints through an optimisation algorithm that minimised tracking errors between measured and simulated kinematics. A five-fold cross validation and a Monte Carlo sensitivity analysis were conducted to assess the performance of the newly estimated parameters. The impact-specific parameters were integrated in a population specific musculoskeletal model and used to assess cervical spine loads measured from Rugby union impacts compared to available models. Results of the optimisation showed a larger increase of axial joint stiffness compared to axial damping and shear viscoelastic parameters for all models. The sensitivity analysis revealed that lower values of axial stiffness and shear damping reduced the models performance considerably compared to other degrees of freedom. The impact-specific parameters integrated in the population specific model estimated more appropriate joint displacements for axial head impacts compared to available models and are therefore more suited for injury mechanism analysis.Rugby Football Union (RFU) Injured Players Foundatio