424 research outputs found
Perte de la parole, ramouissement chronique et destruction partielle du lobe antérieur gauche du cerveau
Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment
In type 2 diabetes, amyloid oligomers, chronic hyperglycemia, lipotoxicity, and pro-inflammatory cytokines are detrimental to beta-cells, causing apoptosis and impaired insulin secretion. The histone acetyl transferase p300, involved in remodeling of chromatin structure by epigenetic mechanisms, is a key ubiquitous activator of the transcriptional machinery. In this study, we report that loss of p300 acetyl transferase activity and expression leads to beta-cell apoptosis, and most importantly, that stress situations known to be associated with diabetes alter p300 levels and functional integrity. We found that proteasomal degradation is the mechanism subserving p300 loss in beta-cells exposed to hyperglycemia or pro-inflammatory cytokines. We also report that melatonin, a hormone produced in the pineal gland and known to play key roles in beta-cell health, preserves p300 levels altered by these toxic conditions. Collectively, these data imply an important role for p300 in the pathophysiology of diabetes
Growth and survival of American oyster Crassostrea virginica on Laguna de las Pilas, Laguna de Términos, Campeche, México: preliminary evaluation [abstract]; Evaluacion preliminar del crecimiento y sobrevivencia del ostion Crassostrea virginica en la Laguna de las Pilas, Laguna de Términos, Campeche, México [resumen]
Localização dos sulcos e giros da face súpero-lateral do cérebro na tomografia computadorizada e na ressonância magnética
Definição do limite anterolateral do lobo occipital em peças anatômicas e exames de imagem
The evolution of tooth wear indices
Tooth wear—attrition, erosion and abrasion—is perceived internationally as an ever-increasing problem. Clinical and epidemiological studies, however, are difficult to interpret and compare due to differences in terminology and the large number of indices that have been developed for diagnosing, grading and monitoring dental hard tissue loss. These indices have been designed to identify increasing severity and are usually numerical. Some record lesions on an aetiological basis (e.g. erosion indices), others record lesions irrespective of aetiology (tooth wear indices); none have universal acceptance, complicating the evaluation of the true increase in prevalence reported. This article considers the ideal requirements for an erosion index. It reviews the literature to consider how current indices have evolved and discusses if these indices meet the clinical and research needs of the dental profession
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