Towards more ecoefficient food production: MFA approach

The food flux comprises four mutually linked loops: 1)plant production, 2)livestock husbandry, 3) food processing industry and 4) human consumption. In the present paper MFA approach has been used to describe the system. A general framework and practical solutions for estimating and balancing the materials flow are outlined. The focus in this paper is agriculture

Towards more ecoefficient food production: MFA approach

The key for the sustainable development is dematerialisation and ecoefficiency. Applied to agriculture ecoefficiency means production of nutritionally better food by using less inputs and by reducing the environmental burden. In restricting the material throughput it is essential to identify the most voluminous material flows and to direct the measures to them. Improving ecoefficiency of the food production requires that the benefits and the inputs are quantified in an unambiguous way and that the inputs are estimated for the whole production chain. A comprehensive view of the whole system is necessary. The food system comprises four mutually linked loops: 1) the plant production 2) the livestock husbandry, 3) the food processing industry and 4) the human consumption. In the present paper MFA approach has been used to describe the system. A general framework for estimating and balancing the materials flow is outlined. The focus is on agriculture, specifically on the materials flow created by the biological metabolism of the animal husbandry. The holistic MFA approach provides means to evaluate environmental and economic consequences of the production. For the decision-makers the MFA approach is a tool to guide the development and to assess the progress towards increasing ecoefficiency within the food system. The results can be used in developing new sustainability indicators. Some of the possibilities are shortly discussed. The study is the first step in developing MFA methods to analyse and to monitor the materials flow of the Finnish food systems. It is a part of the project “The Materials Flow and Ecoefficiency of Agriculture and the Sustainable Compatibility of the Food Production” carried out in collaboration between the MTT - Agrifood Research Finland and the Thule Institute at the University of Oulu. The results are used also in compiling the Finnish physical input-output tables. The study, thus, contributes to the overall development of the materials flow accounting statistics

Finnish CMS-TOB cosmic rack

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Factors associated with decision-making on prophylactic hysterectomy and attitudes towards gynecological surveillance among women with Lynch syndrome (LS) : a descriptive study

To prevent endometrial carcinoma in Lynch syndrome (LS), regular gynecological surveillance visits and prophylactic surgery are recommended. Previous data have shown that prophylactic hysterectomy is an effective means of cancer prevention, while the advantages and disadvantages of surveillance are somewhat unclear. We aimed to evaluate female LS carriers' attitudes towards regular gynecological surveillance and factors influencing their decision-making on prophylactic surgery that have not been well documented. Pain experienced during endometrial biopsies was also evaluated. Postal questionnaires were sent to LS carriers undergoing regular gynecological surveillance. Questionnaires were sent to 112 women with LS, of whom 76 responded (68%). Forty-two (55%) had undergone prophylactic hysterectomy by the time of the study. The majority of responders (64/76; 84.2%) considered surveillance appointments beneficial. Pain level during endometrial biopsy was not associated with the decision to undergo prophylactic surgery. The level of satisfaction the women had with the information and advice provided during surveillance was significantly associated with the history of prophylactic hysterectomy (satisfaction rate of 73.2% versus 31.8% of nonoperated women, p = 0.003). The women who had undergone prophylactic surgery were older than the nonoperated women both at mutation testing (median of 42.3 years versus 31.6 years, p <0.001) and at the time of the study (median of 56.9 years versus 46.0 years, respectively, p <0.001). Women with LS pathogenic variants have positive experiences with gynecological surveillance visits, and their perception of the quality of the information and advice obtained plays an important role in their decision-making concerning prophylactic surgery.Peer reviewe

SCOTROC 2B: feasibility of carboplatin followed by docetaxel or docetaxel–irinotecan as first-line therapy for ovarian cancer

The feasibility of combination irinotecan, carboplatin and docetaxel chemotherapy as first-line treatment for advanced epithelial ovarian carcinoma was assessed. One hundred patients were randomised to receive four 3-weekly cycles of carboplatin (area under the curve (AUC) 7) followed by four 3-weekly cycles of docetaxel 100 mg m−2 (arm A, n=51) or docetaxel 60 mg m−2 with irinotecan 200 mg m−2 (arm B, n=49). Neither arm met the formal feasibility criterion of an eight-cycle treatment completion rate that was statistically greater than 60% (arm A 71% (90% confidence interval (CI) 58–81%; P=0.079; arm B 67% (90% CI 55–78%; P=0.184)). Median-dose intensities were >85% of planned dose for all agents. In arms A and B, 15.6 and 12.2% of patients, respectively, withdrew owing to treatment-related toxicity. Grade 3–4 sensory neurotoxicity was more common in arm A (1.9 vs 0%) and grade 3–4 diarrhoea was more common in arm B (0.6 vs 3.5%). Of patients with radiologically evaluable disease at baseline, 50 and 48% responded to therapy in arms A and B, respectively; at median 17.1 months' follow-up, median progression-free survival was 17.1 and 15.9 months, respectively. Although both arms just failed to meet the formal statistical feasibility criteria, the observed completion rates of around 70% were reasonable. The addition of irinotecan to first-line carboplatin and docetaxel chemotherapy was generally well tolerated although associated with increased gastrointestinal toxicity. Further exploratory studies of topoisomerase-I inhibitors in this setting may be warranted

Search for neutral color-octet weak-triplet scalar particles in proton-proton collisions at root s=8TeV

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Measurement of the t-channel single top quark production cross section in pp collisions at √s =7 TeV

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Forward-backward asymmetry of Drell-Yan lepton pairs in pp collisions at root s=8 TeV

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Measurement of electroweak WZ boson production and search for new physics in WZ plus two jets events in pp collisions at root s=13 TeV

A measurement of WZ electroweak (EW) vector boson scattering is presented. The measurement is performed in the leptonic decay modes WZ -> l nu l'l', where l, l' = e, mu. The analysis is based on a data sample of proton-proton collisions at root s = 13 TeV at the LHC collected with the CMS detector and corresponding to an integrated luminosity of 35.9 fb(-1) . The WZ plus two jet production cross section is measured in fiducial regions with enhanced contributions from EW production and found to be consistent with standard model predictions. The EW WZ production in association with two jets is measured with an observed (expected) significance of 2.2 (2.5) standard deviations. Constraints on charged Higgs boson production and on anomalous quartic gauge couplings in terms of dimension-eight effective field theory operators are also presented. (C) 2019 The Author(s). Published by Elsevier B.V.Peer reviewe

Measurement of the inelastic cross section in proton-lead collisions at root s(NN)=5.02 TeV

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