A clustering based technique for large scale prioritization during requirements elicitation

We consider the prioritization problem in cases where the number of requirements to prioritize is large using a clustering technique. Clustering is a method used to find classes of data elements with respect to their attributes. KMeans, one of the most popular clustering algorithms, was adopted in this research. To utilize k-means algorithm for solving requirements prioritization problems, weights of attributes of requirement sets from relevant project stakeholders are required as input parameters. This paper showed that, the output of running k-means algorithm on requirement sets varies depending on the weights provided by relevant stakeholders. The proposed approach was validated using a requirement dataset known as RALIC. The results suggested that, a synthetic method with scrambled centroids is effective for prioritizing requirements using k-means clustering

A Novel Idea for Coil Collar Structures in Accelerator Superconducting Magnets

The dipoles for several different machines (LHC, SSC, HERA) were designed using non-magnetic metallic collars to contain the superconducting coils. The coils are of two types, main and floating. This paper describes a structure with combined steel and plastic collars. Since the floating collars do not give an important contribution to the global rigidity of the dipole we propose to suppress them. The plastic collars are just fillers to limit the helium contained in the cold mass. Some data about thermoplastic materials to be possibly used for the collars are given and some estimations of mass and cost of this configuration are made. Finally the results of the tests of a 1-m-long twin aperture dipole with mixed steel-plastic collars are shortly described. The replacement of expensive alloys by high performance plastic in non-structural components can be a cost-effective solution in view of future projects where superconducting magnets are involved and contained costs are a key issue

FEM Computations Concerning the Effect of Friction in Two LHC Main Dipole Structures

The mechanical behaviour of a dipole structure is considered when also friction is taken into account, studying its effect on different components and in different conditions. In particular the difference in behavior between a structure with aluminium collars and one with austenitic steel ones was studied

Statistical Studies of the Robustness of the LHC Main Dipole Mechanical Structure

This paper describes two methods used to study the effect of the tolerances of the components on the structure of the LHC main dipole. The first method, called semi-statistical, is useful for the study of the effect of single different parameters and allows the determination of the acceptable variance of the dimensions of magnet components. The second one, fully statistical, allows the study of the combined effect of many parameters. The use of these two methods allowed to evaluate with good confidence the robustness of two different dipole cross-section designs, featuring austenitic and aluminium alloy collars, respectively

BAFF Index and CXCL13 levels in the cerebrospinal fluid associate respectively with intrathecal IgG synthesis and cortical atrophy in multiple sclerosis at clinical onset

Abstract Background B lymphocytes are thought to play a relevant role in multiple sclerosis (MS) pathology. The in vivo analysis of intrathecally produced B cell-related cytokines may help to clarify the mechanisms of B cell recruitment and immunoglobulin production within the central nervous system (CNS) in MS. Methods Paired cerebrospinal fluid (CSF) and serum specimens from 40 clinically isolated syndrome suggestive of MS or early-onset relapsing-remitting MS patients (CIS/eRRMS) and 17 healthy controls (HC) were analyzed for the intrathecal synthesis of IgG (quantitative formulae and IgG oligoclonal bands, IgGOB), CXCL13, BAFF, and IL-21. 3D-FLAIR, 3D-DIR, and 3D-T1 MRI sequences were applied to evaluate white matter (WM) and gray matter (GM) lesions and global cortical thickness (gCTh). Results Compared to HC, CIS/eRRMS having IgGOB (IgGOB+, 26 patients) had higher intrathecal IgG indexes ( p \u2009<\u20090.01), lower values of BAFF Index (11.9\u2009\ub1\u20096.1 vs 17.5\u2009\ub1\u20095.2, p \u2009<\u20090.01), and higher CSF CXCL13 levels (27.7\u2009\ub1\u200933.5 vs 0.9\u2009\ub1\u20091.5, p \u2009<\u20090.005). In these patients, BAFF Index but not CSF CXCL13 levels inversely correlated with the intrathecal IgG synthesis ( r \u2009>\u20090.5 and p \u2009<\u20090.05 for all correlations). CSF leukocyte counts were significantly higher in IgGOB+ compared to IgGOB\u2212 ( p \u2009<\u20090.05) and HC ( p \u2009<\u20090.01), and correlated to CSF CXCL13 concentrations ( r 0.77, p \u2009<\u20090.001). The gCTh was significantly lower in patients with higher CSF CXCL13 levels (2.41\u2009\ub1\u20090.1 vs 2.49\u2009\ub1\u20090.1\ua0mm, p \u2009<\u20090.05), while no difference in MRI parameters of WM and GM pathology was observed between IgGOB+ and IgGOB\u2212. Conclusions The intrathecal IgG synthesis inversely correlated with BAFF Index and showed no correlation with CSF CXCL13. These findings seem to indicate that intrathecally synthesized IgG are produced by long-term PCs that have entered the CNS from the peripheral blood, rather than produced by PCs developed in the meningeal follicle-like structures (FLS). In this study, CXCL13 identifies a subgroup of MS patients characterized by ..

First Experience in the Mass Production of Components for the LHC Dipoles

This paper reports on the manufacturing features and difficulties experienced for the preliminary mass production of the main mechanical components of the dipole cold mass. The production of about 600 km of superconducting coil copper wedges, 5'000 coil layer jump spacers and boxes, 12'500'000 austenitic steel collars and 5'800'000 low-carbon yoke laminations is spread over 4 European countries and involves 6 manufactory firms. The general technical requirements for the manufacturing process as well as the imposed production checks and quality controls are reviewed. An overview of the preliminary results is presented with an outlook towards the analysis and statistical which are in a process to be implemented for the follow-up of the mass production

NMR profiling of grape musts from some Italian regions

With wine fraud, being a widespread problem [1], the need for more sophisticated and precise analytical methods of its detection remains ever persistent. Nuclear magnetic resonance (NMR) spectroscopy has been widely used for analysis of wine in recent years [2,3], but wine musts were much less studied; in fact, only one paper dealt with the NMR spectra of actual musts [4]. Difficulties arise mostly because grape musts are “live” objects, which undergo rapid fermentation at room temperature, if not inhibited either by freezing or chemical preservative; but even such measures are not sufficient to halt it completely [5]. We have investigated over 300 samples of grape must from 17 of 20 different Italian regions using 1H NMR spectroscopy with water signal suppression, postprocessing in the MatLab software with dynamic alignment [6] and optimized binning [7] to alleviate the effect of fermentation on the chemical shifts of mobile protons. After that, multivariate statistics was performed with techniques such as PCA, PLS-DA and OPLS-DA with respect to various group parameters such as regions, vitivinicultural zones, harvest periods and grape varieties. Advantages and drawbacks of each method were addresse

Using Hypervideo to support undergraduate students' reflection on work practices: a qualitative study

Abstract According to several exploratory studies, the HyperVideo seems to be particularly useful in highlighting the existing connections between the school-based and the work-based contexts, between authentic work situations and theoretical underpinnings. This tool and its features, in particular, the video annotation, seems to constitute an instrument which facilitates the students' reflection on work-practices. Even though several researchers have already studied the efficacy of HyperVideo, studies concerning the qualitative differences between a reflection process activated with or without its use are still missing. Therefore, the present contribution is focused on the reflective processes activated by two groups of students engaged in a higher education course while they carry out a reflective activity on work practices using the HyperVideo or not. The aim is to investigate wether the HyperVideo can be useful for students to foster the connection between theoretical concepts and work practices. Through multi-step qualitative analysis which combined Thematic Qualitative Text Analysis and Grounded Theory, a sample of reflective reports drafted by a group of students who employed HiperVideo to make a video-interview on a work-practice and to reflect on it (Group A) was compared with a sample of reflective reports drafted by a group who did not use it to complete the same task (Group B). The results emerging from the comparison of the coding frequencies between the two groups show that HyperVideo can support the reflective processes of students, better connecting theory and professional practice

Spinfoams in the holomorphic representation

We study a holomorphic representation for spinfoams. The representation is obtained via the Ashtekar-Lewandowski-Marolf-Mour\~ao-Thiemann coherent state transform. We derive the expression of the 4d spinfoam vertex for Euclidean and for Lorentzian gravity in the holomorphic representation. The advantage of this representation rests on the fact that the variables used have a clear interpretation in terms of a classical intrinsic and extrinsic geometry of space. We show how the peakedness on the extrinsic geometry selects a single exponential of the Regge action in the semiclassical large-scale asymptotics of the spinfoam vertex.Comment: 10 pages, 1 figure, published versio

Development and Manufacture of the Coil End Spacers of the LHC Pre-series Dipoles

The coil end spacers play an important role in the performance of superconducting coils, as their shape and location determine the mechanical stability of the conductors in the coil ends (and hence the overall coil training performance) and the local field quality. The dipole end spacers are often of a size and a geometry difficult to be industrially series manufactured and measured. Efficiency of the production and related costs are a key issue to achieve the required production rate of the LHC main dipoles at an affordable price. For the latter reasons, a design approach integrating state-of-the-art CAD/CAM optimization techniques allowing to considerably decrease design and machining time was implemented. This paper gives examples and describes the design criteria, the computation methods, the machining and measuring procedures adopted to carry out the pre-series production