First record of Mermithidae (Nematoda) parasitic in Plecoptera

The first record of Nematoda Mermithidae in adults and larvae of two Protonemura species (Plecoptera Nemouridae) and of Isoperla rivulorum (Pictet) (Plecoptera Perlodidae) from North Italy and Bavaria (Germany) is presented. The malformed genitalia of several parasitically castrated adults are described and illustrated. Primi reperti di Mermithidae (Nematoda) endoparassiti di Plecoptera. Viene segnalata per la prima volta la presenza di Mermithidae (Nematoda) nell’addome di adulti e di ninfe di due specie di Protonemura (Plecoptera Nemouridae) e di Isoperla rivulorum (Pictet) (Plecoptera Perlodidae), raccolte rispettivamente nell’Italia settentrionale ed in Baviera (Germania). I genitali malformati di alcuni adulti, deformità causate da castrazione parassitaria, sono descritti e illustrati

Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex

ABSTRACT The trimeric envelope glycoprotein spike (Env) of HIV-1 is the target of vaccine development to elicit broadly neutralizing antibodies (bnAbs). Env trimer instability and heterogeneity in principle make subunit interfaces inconsistent targets for the immune response. Here, we investigate how functional stability of Env relates to neutralization sensitivity to V2 bnAbs and V3 crown antibodies that engage subunit interfaces upon binding to unliganded Env. Env heterogeneity was inferred when antibodies neutralized a mutant Env with a plateau of less than 100% neutralization. A statistically significant correlation was found between the stability of mutant Envs and the MPN of V2 bnAb, PG9, as well as an inverse correlation between stability of Env and neutralization by V3 crown antibody, 447-52D. A number of Env-stabilizing mutations and V2 bnAb-enhancing mutations were identified in Env, but they did not always overlap, indicating distinct requirements of functional stabilization versus antibody recognition. Blocking complex glycosylation of Env affected V2 bnAb recognition, as previously described, but also notably increased functional stability of Env. This study shows how instability and heterogeneity affect antibody sensitivity of HIV-1 Env, which is relevant to vaccine design involving its dynamic apex. IMPORTANCE The Env trimer is the only viral protein on the surface of HIV-1 and is the target of neutralizing antibodies that reduce viral infectivity. Quaternary epitopes at the apex of the spike are recognized by some of the most potent and broadly neutralizing antibodies to date. Being that their glycan-protein hybrid epitopes are at subunit interfaces, the resulting heterogeneity can lead to partial neutralization. Here, we screened for mutations in Env that allowed for complete neutralization by the bnAbs. We found that when mutations outside V2 increased V2 bnAb recognition, they often also increased Env stability-of-function and decreased binding by narrowly neutralizing antibodies to the V3 crown. Three mutations together increased neutralization by V2 bnAb and eliminated binding by V3 crown antibodies. These results may aid the design of immunogens that elicit antibodies to the trimer apex. </jats:p

Synthetic Radar Dataset Generator for Macro-Gesture Recognition

Recent developments in mmWave technology allow the detection and classification of dynamic arm gestures. However, achieving a high accuracy and generalization requires a lot of samples for the training of a machine learning model. Furthermore, in order to capture variability in the gesture class, the participation of many subjects and the conduct of many gestures with different arm speed are required. In case of macro-gestures, the position of the subject must also vary inside the field of view of the device. This would require a significant amount of time and effort, which needs to be repeated in case that the sensor hardware or the modulation parameters are modified. In order to reduce the required manual effort, here we developed a synthetic data generator that is capable of simulating seven arm gestures by utilizing Blender, an open-source 3D creation suite. We used it to generate 600 artificial samples with varying speed of execution and relative position of the simulated subject, and used them to train a machine learning model. We tested the model using a real dataset recorded from ten subjects, using an experimental sensor. The test set yielded 84.2% accuracy, indicating that synthetic data generation can significantly contribute in the pre-training of a model

Effects of intraspecific competition on the life cycle of the stonefly, Nemurella pictetii (Plecoptera: Nemouridae)

Abstract Background: Considerable variation of life cycle duration in given insect species has been frequently recorded. Splitting of populations into cohorts with different life cycle lengths may occur, sometimes even between siblings from the same batch. Larval populations of the stonefly Nemurella pictetii in central Europe regularly split into a very fast developing and a normal univoltine cohort, leading to partial multivoltinism. The causes for such variation remain unknown but presumably act on the larval stage in which most of the life cycle is spent. We therefore studied possible effects of intraspecific competition on growth and development of larvae in the laboratory. Results: Intraspecific competition had important influence on growth and development of the larvae. High larval densities led to reduced growth and retarded development through interference, not through exploitative competition. All specimens were negatively affected by frequent encounters and the resulting disturbance. There were no dominant individuals able to grow and develop faster than the rest, at the expense of the others. Conclusion: Differences in life cycle length of Nemurella pictetii may result from different larval densities in different microhabitats and resultant different degrees of interference competition. Although competition alone probably does not cause splitting of populations into cohorts with different life cycle duration differences in size and development caused by other factors are certainly enhanced by intraspecific competition

Broadband 300-GHz Power Amplifier MMICs in InGaAs mHEMT Technology

In this article, we report on compact solid-state power amplifier (SSPA) millimeter-wave monolithic integrated circuits (MMICs) covering the 280–330-GHz frequency range. The technology used is a 35-nm gate-length InGaAs metamorphic highelectron- mobility transistor (mHEMT) technology. Two power amplifier MMICs are reported, based on a compact unit amplifier cell, which is parallelized two times using two different Wilkinson power combiners. The Wilkinson combiners are designed using elevated coplanar waveguide and air-bridge thin-film transmission lines in order to implement low-loss 70-Ω lines in the back-endof-line of this InGaAs mHEMT technology. The five-stage SSPA MMICs achieve a measured small-signal gain around 20 dB over the 280–335-GHz frequency band. State-of-the-art output power performance is reported, achieving at least 13 dBm over the 286–310-GHz frequency band, with a peak output power of 13.7 dBm (23.4 mW) at 300 GHz. The PA MMICs are designed for a reduced chip width while maximizing the total gate width of 512 μm in the output stage, using a compact topology based on cascode and common-source devices, improving the output power per required chip width significantly

Long quantum channels for high-quality entanglement transfer

High-quality quantum-state and entanglement transfer can be achieved in an unmodulated spin bus operating in the ballistic regime, which occurs when the endpoint qubits A and B are coupled to the chain by an exchange interaction $j_0$ comparable with the intrachain exchange. Indeed, the transition amplitude characterizing the transfer quality exhibits a maximum for a finite optimal value $j_0^{opt}(N)$, where $N$ is the channel length. We show that $j_0^{opt}(N)$ scales as $N^{-1/6}$ for large $N$ and that it ensures a high-quality entanglement transfer even in the limit of arbitrarily long channels, almost independently of the channel initialization. For instance, the average quantum-state transmission fidelity exceeds 90% for any chain length. We emphasize that, taking the reverse point of view, should $j_0$ be experimentally constrained, high-quality transfer can still be obtained by adjusting the channel length to its optimal value.Comment: 12 pages, 9 figure

Unconventional magnetism in the 4d4^{4} based (S=1S=1) honeycomb system Ag3_{3}LiRu2_{2}O6_{6}

We have investigated the thermodynamic and local magnetic properties of the Mott insulating system Ag$_{3}$LiRu$_{2}$O$_{6}$ containing Ru$^{4+}$ (4$d$$^{4}$) for novel magnetism. The material crystallizes in a monoclinic $C2/m$ structure with RuO$_{6}$ octahedra forming an edge-shared two-dimensional honeycomb lattice with limited stacking order along the $c$-direction. The large negative Curie-Weiss temperature ($\theta_{CW}$ = -57 K) suggests antiferromagnetic interactions among Ru$^{4+}$ ions though magnetic susceptibility and heat capacity show no indication of magnetic long-range order down to 1.8 K and 0.4 K, respectively. $^{7}$Li nuclear magnetic resonance (NMR) shift follows the bulk susceptibility between 120-300 K and levels off below 120 K. Together with a power-law behavior in the temperature dependent spin-lattice relaxation rate between 0.2 and 2 K, it suggest dynamic spin correlations with gapless excitations. Electronic structure calculations suggest an $S = 1$ description of the Ru-moments and the possible importance of further neighbour interactions as also bi-quadratic and ring-exchange terms in determining the magnetic properties. Analysis of our $\mu$SR data indicates spin freezing below 5 K but the spins remain on the borderline between static and dynamic magnetism even at 20 mK.Comment: 10 pages, 11 figures. accepted in Phys. Rev.

A 200 GHz Monolithic Integrated Power Amplifier in Metamorphic HEMT Technology

A millimeter-wave monolithic integrated circuit power amplifier operating in the frequency range between 186 and 212 GHz is presented. The amplifier, dedicated to high-resolution imaging radar and communication systems, is realized in a 100 nm gate length metamorphic high electron mobility transistor technology. The three-stage design with four parallel transistors in the output stage achieves a linear gain of more than 12 dB and provides a saturated output power of more than 9 dBm and 7 dBm at 192 and 200 GHz, respectively

Tropically convex constraint satisfaction

A semilinear relation S is max-closed if it is preserved by taking the componentwise maximum. The constraint satisfaction problem for max-closed semilinear constraints is at least as hard as determining the winner in Mean Payoff Games, a notorious problem of open computational complexity. Mean Payoff Games are known to be in the intersection of NP and co-NP, which is not known for max-closed semilinear constraints. Semilinear relations that are max-closed and additionally closed under translations have been called tropically convex in the literature. One of our main results is a new duality for open tropically convex relations, which puts the CSP for tropically convex semilinaer constraints in general into NP intersected co-NP. This extends the corresponding complexity result for scheduling under and-or precedence constraints, or equivalently the max-atoms problem. To this end, we present a characterization of max-closed semilinear relations in terms of syntactically restricted first-order logic, and another characterization in terms of a finite set of relations L that allow primitive positive definitions of all other relations in the class. We also present a subclass of max-closed constraints where the CSP is in P; this class generalizes the class of max-closed constraints over finite domains, and the feasibility problem for max-closed linear inequalities. Finally, we show that the class of max-closed semilinear constraints is maximal in the sense that as soon as a single relation that is not max-closed is added to L, the CSP becomes NP-hard.Comment: 29 pages, 2 figure