1,185 research outputs found
He Was Like One of Us: American Jewry and the Idealization of Abraham Lincoln
A lecture by the 2009 Judaic Studies Scholar-in-Residence, Dr. Gary P. Zola, Executive Director of The Jacob Rader Marcus Center, American Jewish Archives; Associate Professor, Hebrew Union College - Jewish Institute of Religion.https://digitalcommons.fairfield.edu/bennettcenter-posters/1274/thumbnail.jp
Nanometric pitch in modulated structures of twist-bend nematic liquid crystals
The extended Frank elastic energy density is used to investigate the
existence of a stable periodically modulate structure that appears as a ground
state exhibiting a twist-bend molecular arrangement. For an unbounded sample,
we show that the twist-bend nematic phase is characterized by a
heliconical structure with a pitch in the nano-metric range, in agreement with
experimental results. For a sample of finite thickness, we show that the wave
vector of the stable periodic structure depends not only on the elastic
parameters but also on the anchoring energy, easy axis direction, and the
thickness of the sample.Comment: 11 page
Two-year outcome of an observe-and-plan regimen for neovascular age-related macular degeneration treated with Aflibercept.
The purpose of our study was to investigate the two-year outcome of Aflibercept treatment for neovascular age-related macular degeneration (nAMD), using the Observe-and-Plan regimen, an individually planned treatment regimen, based on the predictability of an individual's need for retreatment, aiming to reduce the clinical burden.
Our prospective study used the Observe-and-Plan regimen with Aflibercept to treat nAMD: Three loading doses, followed by monthly observation visits until the disease-recurrence interval was determined, which then was shortened by 2 weeks in a treatment plan for the next three injections without intermediate monitoring visits. The subsequent treatment plans were adjusted according to periodically assessed disease activity. The primary outcome measures were visual acuity changes, number of injections, and number of monitoring visits.
The study included 112 eyes of 102 patients with a mean age of 80.7 years (SD 7.6). Mean visual acuity (VA) improved from 61.8 ETDRS letters (20/60(+2)) at baseline, by 8.5, 8.0, and 6.2 letters at months 3, 12 and 24, respectively. Mean central retinal thickness was 438um at baseline, and reduced by 152um, 155um, and 150um at months 3, 12 and 24, respectively. The mean number of injections was 8.7 and 6.5 in the first and second year, respectively. The mean number of monitoring visits after baseline was 3.8 and 2.8 during the first and second year, respectively.
The Observe-and-Plan regimen significantly improved VA, while fewer monitoring visits were needed as compared to other variable dosing regimens, thus reducing the workload for chronic care management of nAMD
Time-domain behavior of blazar OJ 287 and the binary supermassive black hole conjecture
The proper understanding of blazar variability at the various electromagnetic spectral bands is one goal of multifrequency astrophysics. In this frame a peculiar and controversial phenomenology is the periodicity, postulated for long-term radio or optical flux light curves of about a dozen of blazars. The well-known BL Lac object OJ 287 (PKS 0851+202, S3 0851+20, PG 0851+202, z = 0.306) is not only a high-variable, peculiar, extragalactic source with hints for approximatively cyclical optical outbursts, but it also represents a case of substantial intensive and extensive (long-term) multifrequency observations. This rich database allow us a deeper analysis based on a wide range of variability timescales with some recent results that are highlighted here. © Copyright owned by the author(s).Peer reviewe
Missing data in longitudinal studies: Comparison of multiple imputation methods in a real clinical setting
Cytokine receptor expression in human lymphoid tissue: analysis by fluorescence microscopy
A highly-sensitive flourescence method, capable of detecting cytokine receptors present at low concentrations (around I DO molecules per cell) by flow cytometry, was adapted for use on tissue sections. This method was used to examine the expression of several cytokine receptors in lymphoid ti ss ues. lL-2 receptors were distributed broadly, with higher concentrations in T cell areas. lL-1 receptor Type I was detected in T cell areas and in the follicular mantle, and was strongly expressed on vasc ular endothelium. IL-6 receptor was found at very low concentration, both within and outside germinal centres. The gp 130 molecule, which is involved in the functional receptor complex for IL-6 and several other cytokines, was present at higher concentrations, particularly in the germinal centre. Analysis of receptor expression in secondary lymphoid tissue provides evidence bearing on the physiological roles of cytokines, as these tissues contain cells at various stages of physiological activation located in well-defined functional zones.Heddy Zola, Jodie Ridings, Helen Weedon, Michael Fusco, Roger W. Byard, Peter J. Macardl
Study of coupling loss on bi-columnar BSCCO/Ag tapes by a.c. susceptibility measurements
Coupling losses were studied in composite tapes containing superconducting
material in the form of two separate stacks of densely packed filaments
embedded in a metallic matrix of Ag or Ag alloy. This kind of sample geometry
is quite favorable for studying the coupling currents and in particular the
role of superconducting bridges between filaments. By using a.c. susceptibility
technique, the electromagnetic losses as function of a.c. magnetic field
amplitude and frequency were measured at the temperature T = 77 K for two tapes
with different matrix composition. The length of samples was varied by
subsequent cutting in order to investigate its influence on the dynamics of
magnetic flux penetration. The geometrical factor which takes into
account the demagnetizing effects was established from a.c. susceptibility data
at low amplitudes. Losses vs frequency dependencies have been found to agree
nicely with the theoretical model developed for round multifilamentary wires.
Applying this model, the effective resistivity of the matrix was determined for
each tape, by using only measured quantities. For the tape with pure silver
matrix its value was found to be larger than what predicted by the theory for
given metal resistivity and filamentary architecture. On the contrary, in the
sample with a Ag/Mg alloy matrix, an effective resistivity much lower than
expected was determined. We explain these discrepancies by taking into account
the properties of the electrical contact of the interface between the
superconducting filaments and the normal matrix. In the case of soft matrix of
pure Ag, this is of poor quality, while the properties of alloy matrix seem to
provoke an extensive creation of intergrowths which can be actually observed in
this kind of samples.Comment: 20 pages 11 figure, submitted to Superconductor Science and
Technolog
Curbing the Hepatitis B Epidemic in Asian American Communities: Engaging Local Hospitals
Background. In the United States, more than 50% of the 1.2 million living with hepatitis B infection are Asian Americans (Centers for Disease Control and Prevention [CDC], 2013). In the city of San Francisco, Asian Americans make up 33% of the population and the city itself has the highest rate of liver cancer in the nation (United States Census Bureau, 2010, California Cancer Registry, 2011). In 2007, to address the risk of hepatitis B and liver cancer, the San Francisco Hep B Free Campaign (SFHBF) drew together a comprehensive coalition of key leaders and organizations from media, health care, government, community and business sectors within and beyond the Asian American community. Methods. Based on 13 key informant interviews with stakeholders, this paper explores how SFHBF incorporated local city hospitals as coalition partners to increase knowledge and screening of hepatitis B among Asian Americans throughout San Francisco. Results. Key findings include the various steps needed to involve hospitals including 1) Identify mission and key stakeholders, 2) Create collaborations among hospitals; 3) Identify benefits to hospitals. Implications. This research makes a unique contribution to the literature on engaging hospitals in community health partnerships. The findings have implications for other public health initiatives that are seeking to engage and involve hospitals as partners and collaborators
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