A formalisation and prototype implementation of argumentation for statistical model selection

© 2019 – IOS Press and the authors. The task of data collection is becoming routine in many disciplines and this results in increased availability of data. This routinely collected data provides a valuable opportunity for analysis with a view to support evidence based decision making. In order to confidently leverage the data in support of decision making the most appropriate statistical method needs to be selected, and this can be difficult for an end user not trained in statistics. This paper outlines an application of argumentation to support the analysis of clinical data, that uses Extended Argumentation Frameworks in order to reason with the meta-level arguments derived from preference contexts relevant to the data and the analysis objective of the end user. We outline a formalisation of the argument scheme for statistical model selection, its critical questions and the structure of the knowledge base required to support the instantiation of the arguments and meta-level arguments through the use of Z notation. This paper also describes the prototype implementation of argumentation for statistical model selection based on the Z specification outlined herein.CONSULT EPSRC grant no. EP-P010105-1

Glial cell type-specific changes in spinal dipeptidyl peptidase 4 expression and effects of its inhibitors in inflammatory and neuropatic pain

Altered pain sensations such as hyperalgesia and allodynia are characteristic features of various pain states, and remain difficult to treat. We have shown previously that spinal application of dipeptidyl peptidase 4 (DPP4) inhibitors induces strong antihyperalgesic effect during inflammatory pain. In this study we observed low level of DPP4 mRNA in the rat spinal dorsal horn in physiological conditions, which did not change significantly either in carrageenan-induced inflammatory or partial nerve ligation-generated neuropathic states. In naive animals, microglia and astrocytes expressed DPP4 protein with one and two orders of magnitude higher than neurons, respectively. DPP4 significantly increased in astrocytes during inflammation and in microglia in neuropathy. Intrathecal application of two DPP4 inhibitors tripeptide isoleucin-prolin-isoleucin (IPI) and the antidiabetic drug vildagliptin resulted in robust opioid-dependent antihyperalgesic effect during inflammation, and milder but significant opioid-independent antihyperalgesic action in the neuropathic model. The opioid-mediated antihyperalgesic effect of IPI was exclusively related to mu-opioid receptors, while vildagliptin affected mainly delta-receptor activity, although mu- and kappa-receptors were also involved. None of the inhibitors influenced allodynia. Our results suggest pathology and glia-type specific changes of DPP4 activity in the spinal cord, which contribute to the development and maintenance of hyperalgesia and interact with endogenous opioid systems

Influence of Stimulant Medication and Response Speed on Lateralization of Movement-Related Potentials in Attention-Deficit/Hyperactivity Disorder

Hyperactivity is one of the core symptoms in attention deficit hyperactivity disorder (ADHD). However, it remains unclear in which way the motor system itself and its development are affected by the disorder. Movement-related potentials (MRP) can separate different stages of movement execution, from the programming of a movement to motor post-processing and memory traces. Pre-movement MRP are absent or positive during early childhood and display a developmental increase of negativity. We examined the influences of response-speed, an indicator of the level of attention, and stimulant medication on lateralized MRP in 16 children with combined type ADHD compared to 20 matched healthy controls. We detected a significantly diminished lateralisation of MRP over the pre-motor and primary motor cortex during movement execution (initial motor potential peak, iMP) in patients with ADHD. Fast reactions (indicating increased visuo-motor attention) led to increased lateralized negativity during movement execution only in healthy controls, while in children with ADHD faster reaction times were associated with more positive amplitudes. Even though stimulant medication had some effect on attenuating group differences in lateralized MRP, this effect was insufficient to normalize lateralized iMP amplitudes.A reduced focal (lateralized) motor cortex activation during the command to muscle contraction points towards an immature motor system and a maturation delay of the (pre-) motor cortex in children with ADHD. A delayed maturation of the neuronal circuitry, which involves primary motor cortex, may contribute to ADHD pathophysiology

Fast curing adhesive in wooden panel construction

A new kind of rapid bonding technology for wooden panel construction was developed. Wooden panel construction is used in the industry for prefabricated houses, which builds walls and ceilings on the base of large substructures of wood panel constructions for lightweight and easy deliverable substructures. The most common joints nowadays are stapled or nailed, the panel materials vary from particleboards and OSB-panels to cement-bonded particleboards (on the outside), all joined to timber frames. The new developed fast curing bonding technology offers specific economical and technical advantages by using hot melt adhesive tape. For assembly of the wooden panels the tape is simply clamped between the wooden parts at ambient temperature, there is not tacky. Then the adhesive is activated by conductive resistive electrical heating within only one minute. It was tested with OSB-panels and cement-bonded particleboards (for the outside), all joined to timber frames