Introducing PIONEER: a project to harness big data in prostate cancer research

Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer, consisting of 32 private and public stakeholders from 9 countries across Europe. Launched by the Innovative Medicines Initiative 2 and part of the Big Data for Better Outcomes Programme (BD4BO), the overarching goal of PIONEER is to provide high-quality evidence on prostate cancer management by unlocking the potential of big data. The project has identified critical evidence gaps in prostate cancer care, via a detailed prioritization exercise including all key stakeholders. By standardizing and integrating existing high-quality and multidisciplinary data sources from patients with prostate cancer across different stages of the disease, the resulting big data will be assembled into a single innovative data platform for research. Based on a unique set of methodologies, PIONEER aims to advance the field of prostate cancer care with a particular focus on improving prostate-cancer-related outcomes, health system efficiency by streamlining patient management, and the quality of health and social care delivered to all men with prostate cancer and their families worldwide.Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer, consisting of 32 private and public stakeholders from 9 countries across Europe. In this Perspectives article, the authors introduce the PIONEER project and describe its aims and plans for ultimately improving prostate cancer care through the use of big data

Strong enhancement of second-harmonic generation in all-dielectric resonant waveguide grating

The authors demonstrate that a dielectric resonant waveguide grating can enhance optical second-harmonic generation by a factor of 550 compared to a similar flat surface. Their structure, which consists of purely dielectric and thereby transparent materials, has a low index silicon dioxide grating covered by a high index titanium dioxide layer and it is optimized for the fundamental wavelength of 1064 nm. Polarization dependence of the second-harmonic response suggests that the enhancement arises from the favorable interaction of the resonant waveguide mode and its strong local field with the inherent surface nonlinearity of the dielectric materials.Peer reviewe

Sustainable value creation in event ecosystems – a business models perspective

This conceptual paper aims at characterising event sustainability from a long-term multi-stakeholder perspective, moving beyond the concept of Triple Bottom Line and event greening. Starting from the premise that sustainability should be understood critically in the wider context of society rather than from a conventional event management lens, the paper focuses on how stakeholders create sustainable value for themselves and for society beyond a specific event. Events should be considered as platforms for value creating systems and, as such, they are enabling actors (individuals and organisations) to share and integrate resources in their own social systems. The adoption of a systemic perspective grounded in Service Dominant Logic allows the authors to conceptualise sustainability as Sustainable Value Creation. Constructs derived from Business Models literature are utilised to analyse the key components of Sustainable Value Creation because they offer insights on the complex process of the creation and sharing of sustainable value focusing specifically on the stakeholders’ activities, relationships and resource exchanges