81 research outputs found
Analysis of entrepreneurial propensity of students from the Viseu pole of Portuguese Catholic University
Este artigo pretende mostrar a importância do ensino
superior na promoção do empreendedorismo. Assim,
começa-se com uma análise teórica dos conceitos de
empreendedorismo e de empreendedor e dos principais
motivos que conduzem ao empreendedorismo, bem como dos
obstáculos que o dificultam. Salienta-se também a importância
que o ensino superior tem na promoção do empreendedorismo.
Faz-se, por fim, uma breve evolução histórica da educação
para o empreendedorismo no ensino superior e do que tem
sido feito em Portugal nesta área.
Em termos metodolĂłgicos, apresentam-se os
resultados de um estudo efetuado com 348 alunos do PĂłlo de
Viseu da Universidade CatĂłlica Portuguesa. Este estudo teve
como principal objetivo conhecer a propensĂŁo empreendedora
dos seus alunos. Os resultados obtidos neste estudo sugerem
que os alunos tĂŞm pouca tendĂŞncia empreendedora, o que se
poderá dever aos receios e às dificuldades em desenvolver um
negĂłcio prĂłprio, assim como a alguns fatores que
condicionam a criação e o sucesso de uma empresa. Assim, é fundamental evidenciar a importância do empreendedorismo,
quer para os indivĂduos, quer para a sociedade, e, por isso, Ă©
indispensável fomentar a sua promoção, sobretudo junto da
comunidade escolar.This article aims to show the importance of higher
education in promoting entrepreneurship. So, we start with a
theoretical analysis of the concepts of entrepreneurship and
entrepreneur and the main reasons that lead to
entrepreneurship, such as the obstacles to it. Also highlight the
importance that higher education has to promote
entrepreneurship, and, finally, a brief historical development
of entrepreneurship education in higher education and what
has been done in this area in Portugal.
In methodological terms, we present the results of a
study conducted with 348 students from Viseu pole of the
Portuguese Catholic University. This study aimed to know the
entrepreneurial propensity of their students. The results of this
study suggest that students have little entrepreneurial trend,
which could be due to the fears and difficulties in developing
their own business, as well as some factors that influence the
creation and success of a company. Thus, it is crucial to
highlight the importance of entrepreneurship, both for
individuals and for society, and therefore it is essential to
foster its promotion especially among the school community.info:eu-repo/semantics/publishedVersio
Nuclear Progesterone Receptors Are Up-Regulated by Estrogens in Neurons and Radial Glial Progenitors in the Brain of Zebrafish
In rodents, there is increasing evidence that nuclear progesterone receptors are transiently expressed in many regions of the developing brain, notably outside the hypothalamus. This suggests that progesterone and/or its metabolites could be involved in functions not related to reproduction, particularly in neurodevelopment. In this context, the adult fish brain is of particular interest, as it exhibits constant growth and high neurogenic activity that is supported by radial glia progenitors. However, although synthesis of neuroprogestagens has been documented recently in the brain of zebrafish, information on the presence of progesterone receptors is very limited. In zebrafish, a single nuclear progesterone receptor (pgr) has been cloned and characterized. Here, we demonstrate that this pgr is widely distributed in all regions of the zebrafish brain. Interestingly, we show that Pgr is strongly expressed in radial glial cells and more weakly in neurons. Finally, we present evidence, based on quantitative PCR and immunohistochemistry, that nuclear progesterone receptor mRNA and proteins are upregulated by estrogens in the brain of adult zebrafish. These data document for the first time the finding that radial glial cells are preferential targets for peripheral progestagens and/or neuroprogestagens. Given the crucial roles of radial glial cells in adult neurogenesis, the potential effects of progestagens on their activity and the fate of daughter cells require thorough investigation
Inhibitory effects of pharmacological doses of melatonin on aromatase activity and expression in rat glioma cells
Melatonin exerts oncostatic effects on different kinds of neoplasias, especially on oestrogen-dependent tumours. Recently, it has been described that melatonin, on the basis of its antioxidant properties, inhibits the growth of glioma cells. Glioma cells express oestrogen receptors and have the ability to synthesise oestrogens from androgens. In the present study, we demonstrate that pharmacological concentrations of melatonin decreases the growth of C6 glioma cells and reduces the local biosynthesis of oestrogens, through the inhibition of aromatase, the enzyme that catalyses the conversion of androgens into oestrogens. These results are supported by three types of evidence. Firstly, melatonin counteracts the growth stimulatory effects of testosterone on glioma cells, which is dependent on the local synthesis of oestrogens from testosterone. Secondly, we found that melatonin reduces the aromatase activity of C6 cells, measured by the tritiated water release assay. Finally, by (RT)–PCR, we found that melatonin downregulates aromatase mRNA steady-state levels in these glioma cells. We conclude that melatonin inhibits the local production of oestrogens decreasing aromatase activity and expression. By analogy to the implications of aromatase in other forms of oestrogen-sensitive tumours, it is conceivable that the modulation of the aromatase by pharmacological melatonin may play a role in the growth of glioblastomas
Great Expectations and Hard Times - The (Non-Trivial) Impact of Education on Domestic Terrorism
Delayed Schwann cell and oligodendrocyte remyelination after ethidium bromide injection in the brainstem of Wistar rats submitted to streptozotocin diabetogenic treatment
Un drapeau original
Testas P. Un drapeau original. In: Annales historiques de la Révolution française, n°178, 1964. pp. 500-501
Un drapeau original
Testas P. Un drapeau original. In: Annales historiques de la Révolution française, n°178, 1964. pp. 500-501
Our experience of coloscopy (339 cases) and of endoscopic polypectomy (86 cases)
Les auteurs analysent une expérience de 339 coloscopies dont plus de 72 % ont atteint l'angle gauche au moins, avec une fréquence globale d'échecs inférieure à 15 %. Les indications essentielles leur paraissent être les images douteuses sur le lavement baryté, les hémorragies basses inexpliquées et surtout la polypectomie. 86 polypes ont été enlevés sous contrôle coloscopique avec 15% de polypes dégénérés dont 1 cancer in situ. Seuls 3 malades présentant une atteinte du pied du pédicule ont subi secondairement une résection chirurgicale segmentaire. Deux accidents sont à déplorer : 1 perforation et 1 hémorragie, sans mortalité post-opératoire
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