Cognitive Evaluation: Is It Time to Require Standardized Assessments?

Mounting evidence from across the medical community supports standardized cognitive assessment and intervention. This manuscript presents a clinical perspective on the benefits of utilization of standardized assessments to inform clinical practice. Today’s value-based care initiatives demand standardized testing to support evidence-based practice. Standardized cognitive assessment would wisely be adopted into practice to help practitioners fully identify impairments preventing patients from achieving successful outcomes

Ferromagnetism and interlayer exchange coupling in short period (Ga,Mn)As/GaAs superlattices

Magnetic properties of (Ga,Mn)As/GaAs superlattices are investigated. The structures contain magnetic (Ga,Mn)As layers, separated by thin layers of non-magnetic GaAs spacer. The short period Ga$_{0.93}$Mn$_{0.07}$As/GaAs superlattices exhibit a paramagnetic-to-ferromagnetic phase transition close to 60K, for thicknesses of (Ga,Mn)As down to 23 \AA. For Ga$_{0.96}$Mn$_{0.04}$As/GaAs superlattices of similar dimensions, the Curie temperature associated with the ferromagnetic transition is found to oscillate with the thickness of non magnetic spacer. The observed oscillations are related to an interlayer exchange interaction mediated by the polarized holes of the (Ga,Mn)As layers.Comment: REVTeX 4 style; 4 pages, 2 figure

Older Adults in an LGBT Residential Community: Impact of a Safe Space on Occupation and Well-Being

Background: LGBT seniors have suffered a lifetime of societal and institutional discrimination and health care inequalities. The number of LGBT people 50 years of age and older will surpass five million in the coming decades. LGBT seniors are at greater risk of disability, isolation, physical and mental health issues, and substance abuse. Supportive social environments and networks are correlated with higher quality of life. The purpose of this study was to better understand how living in a safe and secure apartment community specifically for low-income LGBT older adults impacted the residents’ daily life and well-being. Method: This study was designed as a qualitative, single intrinsic case study using photo-elicitation and focus groups with residents in the nation’s first low-income housing complex for LGBT older adults. Results: Data analysis generated five themes: (a) pride and expanded community, (b) improved occupational participation, (c) safety, (d) domestic independence, and (e) control over end-of-life decision-making. Conclusion: The results emphasize the importance of housing affordability, safety, and community level social acceptance as necessary for LGBT older adults. In addition, it was found that personal expression, occupation-based activities for creativity, and community spaces for LGBT older adults contributed toward greater well-being and expanded occupational participation

6-ft High-Power Electric Propulsion Test Port, EPL Tank 5 Installed

High-power electric propulsion is a critical component of NASA s proposed missions to the outer planets. Mission studies have shown that high-power, high-specific-impulse propulsion systems can deliver 2000 kg of scientific payload to Pluto with trip times on the order of 10 years. Of greater significance is the ability of these propulsion systems to place this science payload in orbit around the planet, rather than making the fast fly-bys associated with traditional chemical propulsion systems. Significant ground test programs are required to develop the new technologies needed for thrusters operating at power levels exceeding 20 kW, an order of magnitude above the state of the art

Case Study: Finite Element Method and Artificial Neural Network Models for Flow through Jeziorsko Earthfill Dam in Poland

A finite element method (FEM) and an artificial neural network (ANN) model were developed to simulate flow through Jeziorsko earthfill dam in Poland. The developed FEM is capable of simulating two-dimensional unsteady and nonuniform flow through a nonhomogenous and anisotropic saturated and unsaturated porous body of an earthfill dam. For Jeziorsko dam, the FEM model had 5,497 triangular elements and 3,010 nodes, with the FEM network being made denser in the dam body and in the neighborhood of the drainage ditches. The ANN model developed for Jeziorsko dam was a feedforward three layer network employing the sigmoid function as an activator and the back-propagation algorithm for the network learning. The water levels on the upstream and downstream sides of the dam were input variables and the water levels in the piezometers were the target outputs in the ANN model. The two models were calibrated and verified using the piezometer data collected on a section of the Jeziorsko dam. The water levels computed by the models satisfactorily compared with those measured by the piezometers. The model results also revealed that the ANN model performed as good as and in some cases better than the FEM model. This case study offers insight into the adequacy of ANN as well as its competitiveness against FEM for predicting seepage through an earthfill dam body

The effect of current inhomogeneity on the performance and degradation of Li-S batteries

The effect of thermal gradients on the performance and cycle life of Li-S batteries is studied using bespoke single-layer Li-S cells, with isothermal boundary conditions maintained by Peltier elements. A temperature difference is shown to cause significant current imbalance between parallel connected single-layer cells, causing the hotter cell to provide more charge and discharge capacities during cycling. During charge, significant shuttle is induced in the hotter Li-S cell, causing accelerated degradation of it. A bespoke multi-tab cell in which the inner layers are electrically connected to different tabs versus the outer layers, is used to demonstrate that noticeable current inhomogeneity occurs during the operation of practical multilayer Li-S pouch cells, which is expected to affect their performance and degradation. The observed thermal and current inhomogeneity should have a direct consequence on battery pack and thermal management system design for real world Li-S battery packs

Structural and magnetic properties of GaMnAs layers with high Mn content grown by Migration Enhanced Epitaxy on GaAs(100) substrates

We have grown the ferromagnetic semiconductor GaMnAs containing up to 10% Mn by migration enhanced epitaxy at a substrate temperature of 150^oC. The alternate supply of As2 molecules and Ga and Mn atoms made it possible to grow single crystalline GaMnAs layers at very low substrate temperature, at which conventional molecular beam epitaxial growth under excess As supply is not possible due to As condensation. Secondary ion mass spectroscopy and X-ray diffraction measurements confirmed a higher Mn content in the films grown by this method in comparison to the GaMnAs layers grown by low temperature molecular beam epitaxy. The lattice constant of hypothetical zinc-blende structure MnAs is determined to be 5.9 \AA, which deviates somewhat from previously reported values. This deviation is ascribed to growth-condition dependent density of point defects. It is stressed that this effect must be taken into account for any assessment of Mn content from X-ray diffraction data. Magnetization measurements showed an onset of ferromagnetic ordering around 75 K for the GaMnAs layer with 10% Mn. This means that the trend of falling Curie temperatures with increasing Mn concentrations above 5.5% is broken. We tentatively assign this to the variation of the carrier concentration, including contributions from donor and acceptor centers formed by antisite defects and Mn doping, and increased density of magnetically active Mn ions.Comment: No LaTeX source; gzipped postscript text + 3 gzipped postscript figure

Extensive sampling sheds light on species-level diversity in Palearctic Placobdella (Annelida: Clitellata: Glossiphoniiformes)

The bloodfeeding leech genus Placobdella is dominated by North American diversity, with only a single nominal species known from Central America and one from the Palearctic region. This is likely due to considerable underestimation of Palearctic biodiversity, but investigations into potential hidden diversity are lacking. To shed light on this, the present study introduces new data for specimens initially identified as Placobdella costata from Ukraine (close to the type locality), Italy, Germany, Latvia, Montenegro, Bulgaria, Slovenia, Turkey, Azerbaijan, Tunisia, and Algeria, and uses both nuclear (Internal Transcribed Spacer [ITS] region) and mitochondrial (cytochrome c oxidase subunit I [COI]) sequence data in phylogenetic and DNA barcoding frameworks, in order to better understand species-level diversity. Seven independent lineages are present in the trees, five of which show adequate separation at the COI locus to suggest their unique species-level status (COI distances between these clades range from 4.86 to 8.10%). However, the ITS data suggest that speciation is recent or incipient in these clades, and that not enough time has passed for clear separation at this locus. We discuss the evolutionary and taxonomic implications of our findings and speculate on dispersal events that may have contributed to shaping this pattern of geographic distribution

The frontline antibiotic vancomycin induces a zinc starvation response in bacteria by binding to Zn(II).

Vancomycin is a front-line antibiotic used for the treatment of nosocomial infections, particularly those caused by methicillin-resistant Staphylococcus aureus. Despite its clinical importance the global effects of vancomycin exposure on bacterial physiology are poorly understood. In a previous transcriptomic analysis we identified a number of Zur regulon genes which were highly but transiently up-regulated by vancomycin in Streptomyces coelicolor. Here, we show that vancomycin also induces similar zinc homeostasis systems in a range of other bacteria and demonstrate that vancomycin binds to Zn(II) in vitro. This implies that vancomycin treatment sequesters zinc from bacterial cells thereby triggering a Zur-dependent zinc starvation response. The Kd value of the binding between vancomycin and Zn(II) was calculated using a novel fluorometric assay, and NMR was used to identify the binding site. These findings highlight a new biologically relevant aspect of the chemical property of vancomycin as a zinc chelator.This work was supported by funding from the Royal Society, UK (516002.K5877/ROG), the Medical Research Council, UK (G0700141). A.Z. was supported from the Said foundation and Cambridge Trust.This is the final version of the article. It first appeared from Nature Publishing Group via http://dx.doi.org/10.1038/srep1960