Fast, high fidelity information transmission through spin chain quantum wires

Spin chains have been proposed as quantum wires for information transfer in solid state quantum architectures. We show that huge gains in both transfer speed and fidelity are possible using a minimalist control approach that relies only a single, local, on-off switch actuator. Effective switching time sequences can be determined using optimization techniques for both ideal and disordered chains. Simulations suggest that effective optimization is possible even in the absence of accurate models.Comment: revtex4, 4 pages, 5 figure

On the Contractivity of Hilbert-Schmidt distance under open system dynamics

We show that the Hilbert-Schmidt distance, unlike the trace distance, between quantum states is generally not monotonic for open quantum systems subject to Lindblad semigroup dynamics. Sufficient conditions for contractivity of the Hilbert-Schmidt norm in terms of the dissipation generators are given. Although these conditions are not necessary, simulations suggest that non-contractivity is the typical case, i.e., that systems for which the Hilbert-Schmidt distance between quantum states is monotonically decreasing form only a small set of all possible dissipative systems for N>2, in contrast to the case N=2 where the Hilbert-Schmidt distance is always monotonically decreasing.Comment: Major revision. We would particularly like to thank D Perez-Garcia for constructive feedbac

Clinical and functional characterisation of a novel TNFRSF1A c.605T > A/V173D cleavage site mutation associated with tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS), cardiovascular complications and excellent response to etanercept treatment.

Objectives: To study the clinical outcome, treatment response, T-cell subsets and functional consequences of a novel tumour necrosis factor (TNF) receptor type 1 (TNFRSF1A) mutation affecting the receptor cleavage site. Methods: Patients with symptoms suggestive of tumour necrosis factor receptor-associated periodic syndrome (TRAPS) and 22 healthy controls (HC) were screened for mutations in the TNFRSF1A gene. Soluble TNFRSF1A and inflammatory cytokines were measured by ELISAs. TNFRSF1A shedding was examined by stimulation of peripheral blood mononuclear cells (PBMCs) with phorbol 12-myristate 13-acetate followed by flow cytometric analysis (FACS). Apoptosis of PBMCs was studied by stimulation with TNFa in the presence of cycloheximide and annexin V staining. T cell phenotypes were monitored by FACS. Results: TNFRSF1A sequencing disclosed a novel V173D/ p.Val202Asp substitution encoded by exon 6 in one family, the c.194–14G.A splice variant in another and the R92Q/p.Arg121Gln substitution in two families. Cardiovascular complications (lethal heart attack and peripheral arterial thrombosis) developed in two V173D patients. Subsequent etanercept treatment of the V173D carriers was highly effective over an 18-month follow-up period. Serum TNFRSF1A levels did not differ between TRAPS patients and HC, while TNFRSF1A cleavage from monocytes was significantly reduced in V173D and R92Q patients. TNFa-induced apoptosis of PBMCs and T-cell senescence were comparable between V173D patients and HC. Conclusions: The TNFRSF1A V173D cleavage site mutation may be associated with an increased risk for cardiovascular complications and shows a strong response to etanercept. T-cell senescence does not seem to have a pathogenetic role in affected patients

Energy Disaggregation using Two-Stage Fusion of Binary Device Detectors

A data-driven methodology to improve the energy disaggregation accuracy during Non-Intrusive Load Monitoring is proposed. In detail, the method is using a two-stage classification scheme, with the first stage consisting of classification models processing the aggregated signal in parallel and each of them producing a binary device detection score, and the second stage consisting of fusion regression models for estimating the power consumption for each of the electrical appliances. The accuracy of the proposed approach was tested on three datasets (ECO, REDD and iAWE), which are available online, using four different classifiers. The presented approach improves the estimation accuracy by up to 4.1% with respect to a basic energy disaggregation architecture, while the improvement on device level was up to 10.1%. Analysis on device level showed significant improvement of power consumption estimation accuracy especially for continuous and non-linear appliances across all evaluated datasets

Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria

With the availability of new preventive and curative interventions, global malaria control has been strengthened significantly in recent years. Drugs effective in reducing malaria gametocytaemia might contribute to local elimination and possible long-term eradication. We here report on the effects of methylene blue (MB)-based malaria combination therapy on gametocytaemia during a randomised-controlled trial in Burkina Faso. An open-label randomised controlled phase II study in 180 children aged 6-10 years with uncomplicated falciparum malaria was conducted in Nouna, north-western Burkina Faso. Children were randomised to MB-artesunate (AS), MB-amodiaquine (AQ), and AS-AQ (local standard of care). Overall follow-up was for 28 days, follow-up for gametocytaemia was for 14 days. The treatment groups were similar in baseline characteristics and there was only one loss to follow-up. Compared to AS-AQ, both MB-containing regimens were associated with significantly reduced gametocyte carrier rates during follow-up days 3, 7, and 14. This effect was seen both in patients with and without P. falciparum gametocytaemia at baseline. MB reveals pronounced gametocytocidal activity which appears to act against both existing and developing P. falciparum gametocytes. MB-based combination therapy thus has the potential to reduce transmission of P. falciparum malaria in endemic regions, which has important implications for future elimination and eradication strategies

Beyond the pale?: the implications of the RSLG Report for non-CURL modern university libraries: Perspectives on the support libraries group: Final report

We have shown that the cluster-mass reconstruction method which combines strong and weak gravitational lensing data, developed in the first paper in the series, successfully reconstructs the mass distribution of a simulated cluster. In this paper we apply the method to the ground-based high-quality multi-colour data of RX J1347.5-114

Late-time tails of a Yang-Mills field on Minkowski and Schwarzschild backgrounds

We study the late-time behavior of spherically symmetric solutions of the Yang-Mills equations on Minkowski and Schwarzschild backgrounds. Using nonlinear perturbation theory we show in both cases that solutions having smooth compactly supported initial data posses tails which decay as $t^{-4}$ at timelike infinity. Moreover, for small initial data on Minkowski background we derive the third-order formula for the amplitude of the tail and confirm numerically its accuracy.Comment: 7 pages, 3 figure