Anti-MuSK-positive myasthenia gravis diagnosed during pregnancy: New challenges for an old disease

Myasthenia gravis is an autoimmune disorder affecting predominantly women in their reproductive age. The course of the disease during pregnancy is unpredictable, although it is more difficult to manage earlier in the gestation. Myasthenia gravis with antibodies against the muscle-specific receptor tyrosine kinase (anti-MuSK) has been described as a subtype of disease with more localised clinical features and a poorer response to treatment than acetylcholine receptor antibody (anti-AChR)-positive patients. Few cases have been reported in pregnant women, with deliveries being performed mainly by caesarean section. We report a successful case of vaginal delivery and describe our experience providing the first review of the management of this subtype of disease during pregnancy

Tempo quente e seco antecipa parte da safra de uva 2013 e o total produzido poderá superar 2012.

bitstream/item/74968/1/22-01-13-uva.pdf; bitstream/item/82448/1/MONTEIRO-Agrolink-jan2013.pdfCultivar, Pelotas, 22 jan. 2013. Publicado também no site da Agrolink em 17/01/13

An experimental study of gill net and trammel net 'ghost fishing' off the Algarve (southern Portugal)

Four 100 m lengths of both monofilament gill nets and trammel nets were deployed at depths between 15 and 18 m off the coast of the Algarve (south of Portugal) between April 1995 and June 1996. The nets were set on a natural rocky bottom with one end cut loose to simulate lost nets. Changes in net structure (net height, effective fishing area, movement, colonisation, wear and tear) and their catches (species, sizes, numbers, and biomass) were monitored by divers. Similar patterns were observed in all the nets, with a sharp decrease in net height and effective fishing area, and an increase in visibility within the first few weeks. Net movement was negligible except in the case of interference from other fishing gears. Catch rates were initially comparable to normally fished gill nets and trammel nets in this area, but decreased steadily over time. No sea birds, reptiles or mammals were caught in any of the 8 nets. Catches were dominated by fish (89 % by number, at least 27 species), in particular by sea breams (Sparidae) and wrasses (Labridae). Under the conditions experienced throughout the study the fishing Lifetime of a 'lost' net is between 15 and 20 wk. Based on an exponential model, we estimated that 100 m lengths of gill net and trammel net will catch 314 and 221 fish respectively over a 17 wk period. However, we consider this to be an underestimate due to high rates of predation and scavenging by octopuses, cuttlefish, moray eels, conger eels, and other fish such as the wrasse Coris julis. When the nets were surveyed in the following spring, 8 to 11 mo after being deployed, they were found to be completely destroyed or heavily colonised by algae and had become incorporated into the reef

Acúmulo de matéria seca dos capins Panicum maximum cv. Tanzânia, cv. Tobiatã e Pennisetum purpureum.

Disponível em: . Acesso em: 10 dez. 2003

Caracterização de acessos Paspalum para sistemas intensivos de produção no Estado de São Paulo:exigências nutricionais.

Editores técnicos: João de Mendonça Naime, Caue Ribeiro, Maria Alice Martins, Elaine Cristina Paris, Paulino Ribeiro Villas Boas, Ladislau Marcelino Rabello

Primary and secondary scintillation measurements in a xenon Gas Proportional Scintillation Counter

NEXT is a new experiment to search for neutrinoless double beta decay using a 100 kg radio-pure high-pressure gaseous xenon TPC. The detector requires excellent energy resolution, which can be achieved in a Xe TPC with electroluminescence readout. Hamamatsu R8520-06SEL photomultipliers are good candidates for the scintillation readout. The performance of this photomultiplier, used as VUV photosensor in a gas proportional scintillation counter, was investigated. Initial results for the detection of primary and secondary scintillation produced as a result of the interaction of 5.9 keV X-rays in gaseous xenon, at room temperature and at pressures up to 3 bar, are presented. An energy resolution of 8.0% was obtained for secondary scintillation produced by 5.9 keV X-rays. No significant variation of the primary scintillation was observed for different pressures (1, 2 and 3 bar) and for electric fields up to 0.8 V cm-1 torr-1 in the drift region, demonstrating negligible recombination luminescence. A primary scintillation yield of 81 \pm 7 photons was obtained for 5.9 keV X-rays, corresponding to a mean energy of 72 \pm 6 eV to produce a primary scintillation photon in xenon.Comment: 16 pages, 10 figures, accepted for publication in JINS

The Arena: An indoor mixed reality space

ln this paper, we introduce the Arena, an indoor space for mobile mixed reality interaction. The Arena includes a new user tracking system appropriate for AR/MR applications and a new Too/kit oriented to the augmented and mixed reality applications developer, the MX Too/kit. This too/kit is defined at a somewhat higher abstraction levei, by hiding from the programmer low-level implementation details and facilitating ARJMR object-oriented programming. The system handles, uniformly, video input, video output (for headsets and monitors), sound aurelisation and Multimodal Human-Computer Interaction in ARJMR, including, tangible interfaces, speech recognition and gesture recognition.info:eu-repo/semantics/publishedVersio

Disseminated Well-Differentiated Gastro-Entero-Pancreatic Tumors Are Associated with Metabolic Syndrome

The association of well-differentiated gastro-entero-pancreatic neuroendocrine tumors (WD GEP-NETs) with metabolic syndrome (MetS), abdominal obesity, and fasting glucose abnormalities was recently described. The aim of this study was to evaluate whether the presence of MetS or any MetS individual component was also influenced by GEP-NET characteristics at diagnosis. A cohort of patients with WD GEP-NETs (n = 134), classified according to primary tumor location (gastrointestinal or pancreatic), pathological grading (G1 (Ki67 ≤ 2%) and G2 (>3 ≤ 20%) (WHO 2010), disease extension (localized, loco-regional, and metastatic), and presence of hormonal secretion syndrome (functioning/non-functioning), was evaluated for the presence of MetS criteria. After adjustment for age and gender, the odds of having MetS was significantly higher for patients with WD GEP-NET grade G1 (OR 4.35 95%CI 1.30-14.53) and disseminated disease (OR 4.52 95%CI 1.44-14.15). GEP-NET primary tumor location or secretory syndrome did not influence the risk for MetS. None of the tumor characteristics evaluated were associated with body mass index, fasting plasma glucose category, or any of the individual MetS components. Patients with GEP-NET and MetS depicted a higher risk of presenting a lower tumor grade and disseminated disease. The positive association between MetS and GEP-NET characteristics further highlights the potential link between the two conditions.info:eu-repo/semantics/publishedVersio

Climate change impacts on water resources and reservoir management: uncertainty and adaptation for a mountain catchment in Northeast Portugal

Reservoirs often play an important role in mitigating water supply problems. However, the implications of climate change are not always considered in reservoir planning and management. This study aimed to address this challenge in the Alto Sabor watershed, northeast Portugal. The study analysed whether or not the shortage of water supply can be effectively addressed through the construction of a new reservoir (two-reservoir system) by considering future climate projections. The hydrological model Soil and Water Assessment Tool (SWAT) was calibrated and validated against daily-observed discharge and reservoir volume, with a good agreement between model predictions and observations. Outputs from four General Circulation Models (GCM) for two scenarios (RCP 4.5 and 8.5) were statistically downscaled and bias-corrected with ground observations. A general increase in temperature is expected in the future while the change in precipitation is more uncertain as per the differences among climatic models. In general, annual precipitation would slightly decrease while seasonal changes would be more significant, with more precipitation in winter and much less in spring and summer. SWAT simulations suggest that the existence of two-reservoir will better solve the water supply problems under current climate conditions compared to a single-reservoir system. However in the future, the reliability of this solution will decrease, especially due to the variability of projections from the different climatic models. The solution to water supply problems in this region, adopted taking only present-day climate into account, will likely be inefficient for water supply management under future climate conditions.This work was funded by FEDER funds through the Operational Programme for Competitiveness Factors - COMPETE and by National Funds through FCT - Foundation for Science and Technology under the project PTDC/AAG-MAA/4539/2012 / FCOMP-01-0124-FEDER-027863 (IND_CHANGE). J.P. Nunes was financially supported by FCT (Portuguese Science Foundation), and the European Social Fund through post-doctoral grant (SFRH/BPD/87571/2012). A.T. Monteiro is supported by FEDER funds through the Operational Programme for Competitiveness Factors - COMPETE and by National Funds through FCT - Foundation for Science and Technology under the UID/BIA/50027/2013 and POCI-01-0145-FEDER-006821. The authors would like to thank the Municipality of Bragança for the datasets on water inflows.info:eu-repo/semantics/publishedVersio