Gold coated YBCO films for room temperature FET -sensors

264-267<span style="font-size: 15.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">The thin films of high <span style="font-size:13.0pt;mso-bidi-font-size:6.0pt; font-family:HiddenHorzOCR;mso-hansi-font-family:" times="" new="" roman";mso-bidi-font-family:="" hiddenhorzocr"="">Tc <span style="font-size:15.0pt;mso-bidi-font-size: 8.0pt;font-family:" times="" new="" roman","serif""="">cuprates are sensitive to gases at room temperature and are highly suitable for development of silicon based FET -sensors. However, an appropriate passivation is needed for their incorporation in silicon-CMOS technology. Utilization of thin gold films for this purpose is reported here for the gas sensing properties of gold-coated YBCO films. RF magnetron sputtering is used to deposit YBCO films on oxidized silicon substrates. These films are then coated with a thin gold layer and used to construct discrete structures of capacitively controlled field effect transistor <span style="font-size: 15.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">(CCFET) sensors to investigate their gas detection properties. The measurement technique and sensor response are discussed in detail. The results evince that gold-coated YBCO films are sensitive to ammonia at room temperature and can be employed as sensitive layer in integrated silicon-FET sensors for detection of ammonia. </span

A material for room temperature FET sensor to detect ammonia and hydrocarbon gases

336-339<span style="font-size: 15.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">Cobalt oxide has been reported as a new material for room temperature FET gas sensor. Thin films of cobalt oxide have been prepared by DC magnetron sputtering on oxidized silicon substrates and used as gas sensitive layers in a capacitively controlled field effect transistor (CCFET) structures. CCFET is a MOSFET with an extended gate electrode. Gas sensing behaviour of these films has been investigated at room temperature for different gases of varying concentrations, ranging from 10 ppm to <span style="font-size:15.5pt;mso-bidi-font-size:8.5pt;font-family: " times="" new="" roman","serif""="">10,000 <span style="font-size:15.0pt; mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">ppm. Gases such as CH<span style="font-size:13.0pt;mso-bidi-font-size:6.0pt; font-family:" times="" new="" roman","serif""="">4<span style="font-size: 13.0pt;mso-bidi-font-size:6.0pt;font-family:" times="" new="" roman","serif""="">, C3H8, NH3, CO, NO and H2 have been used to study the sensor performance. Since the measured sensor signal is not amplified, it is a direct measure of sensitivity of the film to a gas to which it is exposed. The CCFET structure, preparation of sensitive films and measurements are described in this paper. The results indicate that cobalt oxide is selectively sensitive to ammonia and hydrocarbon gases only with a little or negligible response to other gases. Signals of 5 mV and <span style="font-size:15.5pt;mso-bidi-font-size: 8.5pt;font-family:" times="" new="" roman","serif""="">30 <span style="font-size: 15.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">mV for 10 ppm of the hydrocarbons and ammonia respectively have been observed. </span

LPCVD and PECVD silicon nitride for microelectronics technology

303-309<span style="font-size: 15.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">Silicon nitride deposition by chemical vapour deposition (CYD) based techniques like low pressure CYD (LPCYD) and plasma enhanced CYD (PECYD) is described in this paper. The technological advantages of silicon nitride deposition by these two techniques, developed at CEERI, are discussed in detail. Applications of LPCYD nitride films for LOCOS, <span style="font-size: 15.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">composite gate structures for MNOS and MOS devices are highlighted. The importance of PECYD nitride films for diffusion masking of compound semiconductors, and for passivation in Si, GaAs, and InP devices are demonstrated. Process parameters of LPCYD and PECYD nitride deposition have been optimized for various substrate conditions depending on the technological requirements. Material properties are being explored for various micromachining activities, which includes diaphragm , cantilever, and beam formations. </span

Appraisal of Pancreatic Lipase Inhibitory Potential of <i>Ziziphus oenoplia (L.)Mill.</i> Leaves by <i>In Vitro</i> and <i>In Silico</i> Approaches

Pancreatic lipase is one of the crucial lipolytic enzymes of the gut that actively facilitates the digestion and absorption of the dietary triglycerides and cholesteryl esters. Although it has been deemed as one of the most reliable targets for the treatment of obesity and/or dyslipidemia, to date, orlistat is the only known FDA-approved, effective, oral pancreatic lipase inhibitor available for clinical use apart from the centrally acting antiobesity agents. However, it is known to be associated with adverse gastrointestinal and renal complications. In this study, we attempted to assess the antioxidant and porcine pancreatic lipase inhibitory potentials of Ziziphus oenoplia (L.)Mill. leaves through a systematic combination of in vitro and in silico approaches. Among the four different extracts including petroleum ether extract, ethyl acetate extract, ethanolic extract, and aqueous extract obtained through successive solvent extraction, the ethyl acetate extract has outperformed the other extracts and orderly displayed competent peroxide scavenging (IC50 value: 267.30 μg/mL) and porcine pancreatic lipase inhibitory (IC50 value: 444.44 μg/mL) potentials compared to the selected reference compounds: ascorbic acid (IC50 value: 251.50 μg/mL) and orlistat (IC50 value: 502.51 μg/mL) in the selected in vitro assay models. In addition, based on the molecular docking simulations of the six essential phytoconstituents of the leaves of Ziziphus oenoplia (L.)Mill. and their respective chemical analogues against the crystal structure of pancreatic lipase–colipase complex (PDB ID: 1LPB), four best-ranked molecules (PubChem CIDs: 15515703, 132582306, 11260294, and 44440845) have been proposed. Further, among these, the interaction potentials of the two top-ranked molecules (PubChem CIDs: 132582306 and 15515703) were analyzed through molecular dynamics (MD) simulations at a trajectory of 100 ns. Finally, absorption, distribution, metabolism, excretion, and toxicity (ADMET) parameters were theoretically predicted for all of the molecules using Swiss ADME and ADMET lab2.0. In conclusion, Ziziphus oenoplia (L.)Mill. leaves could become a prominent source for various potent bioactive compounds that may serve as prospective leads for the development of clinically cognizable pancreatic lipase inhibitors, provided their pharmacokinetic and in particular toxicity properties are thoroughly optimized