Optical absorption spectrum in disordered semiconductor multilayers

The effects of chemical disorder on the electronic and optical properties of semiconductor alloy multilayers are studied based on the tight-binding theory and single-site coherent potential approximation. Due to the quantum confinement of the system, the electronic spectrum breaks into a set of subbands and the electronic density of states and hence the optical absorption spectrum become layer-dependent. We find that, the values of absorption depend on the alloy concentration, the strength of disorder, and the layer number. The absorption spectrum in all layers is broadened because of the influence of disorder and in the case of strong disorder regime, two optical absorption bands appear. In the process of absorption, most of the photon energy is absorbed by the interior layers of the system. The results may be useful for the development of optoelectronic nanodevices.Comment: 6 pages, 6 EPS figures, revised versio

Privacy-Preserving Image Sharing via Sparsifying Layers on Convolutional Groups

We propose a practical framework to address the problem of privacy-aware image sharing in large-scale setups. We argue that, while compactness is always desired at scale, this need is more severe when trying to furthermore protect the privacy-sensitive content. We therefore encode images, such that, from one hand, representations are stored in the public domain without paying the huge cost of privacy protection, but ambiguated and hence leaking no discernible content from the images, unless a combinatorially-expensive guessing mechanism is available for the attacker. From the other hand, authorized users are provided with very compact keys that can easily be kept secure. This can be used to disambiguate and reconstruct faithfully the corresponding access-granted images. We achieve this with a convolutional autoencoder of our design, where feature maps are passed independently through sparsifying transformations, providing multiple compact codes, each responsible for reconstructing different attributes of the image. The framework is tested on a large-scale database of images with public implementation available.Comment: Accepted as an oral presentation for ICASSP 202

Protection of mice by a λ-based therapeutic vaccine against cancer associated with human papillomavirus type 16

Objective: Human papillomavirus (HPV) oncoproteins (i.e. E6 and E7) are constitutively expressed in cervical cancer cells. The proteins are ideal targets to be used for developing therapeutic vaccines against existing HPV-associated carcinomas. To date, whole bacteriophage ('phage')-λ particles, rather than purified 'naked' DNA, have been described as highly efficient delivery vehicles for a DNA vaccine. Methods: In this study, a safe and efficient λ-based therapeutic cancer vaccine, recombinant λ-ZAP E7 phage, was developed by inserting a HPV16 E7 gene into the Lambda ZAP® cytomegalovirus vector. λ-ZAP E7 phages were employed to immunize mice against the E7-expressing murine tumor cell line (TC-1), which is used as a tumor model in an H-2b murine system. Results: The tumor-bearing mice indicated a significant inhibition of tumor growth after 3 injections of 2 × 1012 particles of recombinant phages. Released lactate dehydrogenase, interferon-γ and granzyme B from spleen cells and lymphocyte proliferation of spleen cells, which all demonstrate the enhancement of cell-mediated immunity, suggested the phages could be a potent gene delivery system in animal models. Conclusion: Our results suggest the recombinant phages can be used as effective biological tools for inducing E7-specific protective immune responses. Hence, the study introduces a possible therapeutic strategy against cervical cancer and other HPV-related neoplasia. Copyright © 2010 S. Karger AG, Basel

Effect of CO2 exposure on the mechanical strength of geopolymer-stabilized sandy soils

This is the final version. Available on open access from Elsevier via the DOI in this recordIn recent years, there has been growing interest in developing methods for mitigating greenhouse effect, as greenhouse gas emissions continue to contribute to global temperature rise. On the other hand, investigating geopolymers as environmentally friendly binders to mitigate the greenhouse effect using soil stabilization has been widely conducted. However, the effect of CO2 exposure on the mechanical properties of geopolymer-stabilized soils is rarely reported. In this context, the effect of CO2 exposure on the mechanical and microstructural features of sandy soil stabilized with volcanic ash-based geopolymer was investigated. Several factors were concerned, for example the binder content, relative density, CO2 pressure, curing condition, curing time, and carbonate content. The results showed that the compressive strength of the stabilized sandy soil specimens with 20% volcanic ash increased from 3 MPa to 11 MPa. It was also observed that 100 kPa CO2 pressure was the optimal pressure for strength development among the other pressures. The mechanical strength showed a direct relationship with binder content and carbonate content. Additionally, in the ambient curing (AC) condition, the mechanical strength and carbonate content increased with the curing time. However, the required water for carbonation evaporated after 7 d of oven curing (OC) condition and as a result, the 14-d cured samples showed lower mechanical strength and carbonate content in comparison with 7-d cured samples. Moreover, the rate of strength development was higher in OC cured samples than AC cured samples until 7 d due to higher geopolymerization and carbonation rate.MatSoil CompanyEuropean Union Horizon 202

X-ray and MR contrast bearing nanoparticles enhance the therapeutic response of image-guided radiation therapy for oral cancer

INTRODUCTION: Radiation therapy for head and neck squamous cell carcinoma is constrained by radiotoxicity to normal tissue. We demonstrate 100 nm theranostic nanoparticles for image-guided radiation therapy planning and enhancement in rat head and neck squamous cell carcinoma models. METHODS: PEG conjugated theranostic nanoparticles comprising of Au nanorods coated with Gadolinium oxide layers were tested for radiation therapy enhancement in 2D cultures of OSC-19-GFP-luc cells, and orthotopic tongue xenografts in male immunocompromised Salt sensitive or SS rats via both intratumoral and intravenous delivery. The radiation therapy enhancement mechanism was investigated. RESULTS: Theranostic nanoparticles demonstrated both X-ray/magnetic resonance contrast in a dose-dependent manner. Magnetic resonance images depicted optimal tumor-to-background uptake at 4 h post injection. Theranostic nanoparticle + Radiation treated rats experienced reduced tumor growth compared to controls, and reduction in lung metastasis. CONCLUSIONS: Theranostic nanoparticles enable preprocedure radiotherapy planning, as well as enhance radiation treatment efficacy for head and neck tumors

Changes in Cardiac Substrate Transporters and Metabolic Proteins Mirror the Metabolic Shift in Patients with Aortic Stenosis

In the hypertrophied human heart, fatty acid metabolism is decreased and glucose utilisation is increased. We hypothesized that the sarcolemmal and mitochondrial proteins involved in these key metabolic pathways would mirror these changes, providing a mechanism to account for the modified metabolic flux measured in the human heart. Echocardiography was performed to assess in vivo hypertrophy and aortic valve impairment in patients with aortic stenosis (n = 18). Cardiac biopsies were obtained during valve replacement surgery, and used for western blotting to measure metabolic protein levels. Protein levels of the predominant fatty acid transporter, fatty acid translocase (FAT/CD36) correlated negatively with levels of the glucose transporters, GLUT1 and GLUT4. The decrease in FAT/CD36 was accompanied by decreases in the fatty acid binding proteins, FABPpm and H-FABP, the β-oxidation protein medium chain acyl-coenzyme A dehydrogenase, the Krebs cycle protein α-ketoglutarate dehydrogenase and the oxidative phosphorylation protein ATP synthase. FAT/CD36 and complex I of the electron transport chain were downregulated, whereas the glucose transporter GLUT4 was upregulated with increasing left ventricular mass index, a measure of cardiac hypertrophy. In conclusion, coordinated downregulation of sequential steps involved in fatty acid and oxidative metabolism occur in the human heart, accompanied by upregulation of the glucose transporters. The profile of the substrate transporters and metabolic proteins mirror the metabolic shift from fatty acid to glucose utilisation that occurs in vivo in the human heart

W18O49 Nanowires as Ultraviolet Photodetector

Photodetectors in a configuration of field effect transistor were fabricated based on individual W18O49 nanowires. Evaluation of electrical transport behavior indicates that the W18O49 nanowires are n-type semiconductors. The photodetectors show high sensitivity, stability and reversibility to ultraviolet (UV) light. A high photoconductive gain of 104 was obtained, and the photoconductivity is up to 60 nS upon exposure to 312 nm UV light with an intensity of 1.6 mW/cm2. Absorption of oxygen on the surface of W18O49 nanowires has a significant influence on the dark conductivity, and the ambient gas can remarkably change the conductivity of W18O49 nanowire. The results imply that W18O49 nanowires will be promising candidates for fabricating UV photodetectors