Anatomical and biomechanical traits of broiler chickens across ontogeny. Part II. Body segment inertial properties and muscle architecture of the pelvic limb

In broiler chickens, genetic success for desired production traits is often shadowed by welfare concerns related to musculoskeletal health. Whilst these concerns are clear, a viable solution is still elusive. Part of the solution lies in knowing how anatomical changes in afflicted body systems that occur across ontogeny influence standing and moving. Here, to demonstrate these changes we quantify the segment inertial properties of the whole body, trunk (legs removed) and the right pelvic limb segments of five broilers at three different age groups across development. We also consider how muscle architecture (mass, fascicle length and other properties related to mechanics) changes for selected muscles of the pelvic limb. All broilers used had no observed lameness, but we document the limb pathologies identified post mortem, since these two factors do not always correlate, as shown here. The most common leg disorders, including bacterial chondronecrosis with osteomyelitis and rotational and angular deformities of the lower limb, were observed in chickens at all developmental stages. Whole limb morphology is not uniform relative to body size, with broilers obtaining large thighs and feet between four and six weeks of age. This implies that the energetic cost of swinging the limbs is markedly increased across this growth period, perhaps contributing to reduced activity levels. Hindlimb bone length does not change during this period, which may be advantageous for increased stability despite the increased energetic costs. Increased pectoral muscle growth appears to move the centre of mass cranio-dorsally in the last two weeks of growth. This has direct consequences for locomotion (potentially greater limb muscle stresses during standing and moving). Our study is the first to measure these changes in the musculoskeletal system across growth in chickens, and reveals how artificially selected changes of the morphology of the pectoral apparatus may cause deficits in locomotion

The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict

Bacterial genomes commonly contain ‘addiction’ gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy. However, loss of the complex (including segregational loss in daughter cells) can entail death of the cell. We develop a theoretical model to explore a number of evolutionary puzzles posed by toxin–antitoxin (TA) population biology. We first extend earlier results demonstrating that TA complexes can spread on plasmids, as an adaptation to plasmid competition in spatially structured environments, and highlight the role of kin selection. We then considered the emergence of TA complexes on plasmids from previously unlinked toxin and antitoxin genes. We find that one of these traits must offer at least initially a direct advantage in some but not all environments encountered by the evolving plasmid population. Finally, our study predicts non-transitive ‘rock-paper-scissors’ dynamics to be a feature of intragenomic conflict mediated by TA complexes. Intragenomic conflict could be sufficient to select deleterious genes on chromosomes and helps to explain the previously perplexing observation that many TA genes are found on bacterial chromosomes

Correlated spin-down rates and radio emission in PSR B1859+07

We study the spin-down changes of PSR B1859$+$07 over a period of more than 28 years of radio observation. We identify that the time derivative of the rotational frequency ($\nu$) varies quasi-periodically with a period of $\sim$350 days, switching mainly between two spin-down states. The profile shape of the pulsar is correlated with the $\dot \nu$ variation, producing two slightly different profile shapes corresponding to high- and low-$\dot \nu$ states. In addition to these two normal emission states, we confirm the occasional flare-state of the pulsar, in which the emission appears early in spin phase compared to that of the common normal emission. The profile of the flare-state is significantly different from that of the two normal emission states. The correlation analysis further shows that the flare-state is not directly linked with the $\dot \nu$ changes. With a simple emission beam model, we estimate the emission altitude of the normal emission to be 240~km, and explain the origin of the flare-state as an emission height variation from the leading edge of the beam. We also argue that the emission of these states can be explained with a partially active beam model. In this scenario, the trailing portion of the radio beam is usually active and the normal emission is produced. The flare-state occurs when the leading edge of the beam becomes active while the trailing part is being blocked. This model estimates a fixed emission altitude of 360~km. However, the cause of the flare-state (i.e. the emission height variation, or the time-dependent activity across the radio beam) is not easily explained.Comment: 9 pages, 8 figures, Accepted by MNRAS on 14 October 201

White coat hypertension is associated with increased small vessel disease in the brain

Objective: Small vessel disease, as measured by white matter hyperintensity (WMH) in the brain, is known to be associated with increased stroke risk and cognitive impairment. This study explored the relationship between WMH on computerised tomography (CT) and white coat hypertension/effect (WCH/E) in patients with recent transient ischaemic attack (TIA) or lacunar stroke (LS). Design and method: Ninety-six patients recruited for the ASIST trial (Arterial Stiffness in Lacunar Stroke and TIA) underwent measurement of clinic blood pressure (BP) and ambulatory BP monitoring (APBM) within two weeks of TIA or LS. Twenty-three patients had normotension (clinic BP / = 140/90mmHg and day-time ABPM < 135/85mmHg). Arterial stiffness was measured using carotid-femoral pulse wave velocity (PWV) (Complior®, ALAM Medical) and carotid-ankle vascular index (CAVI) (VaSera VS-1500N®, Fukuda Denshi). CT images were scored for WMH using the four-point Fazekas visual rating scale. Patients were grouped into no-mild WMH (scores 0–1) or moderate-severe (scores 2–3) groups. The relationship between BP, vascular stiffness and WMH was explored with t-tests, chi-square and logistic regression accounting for known cardiovascular risk factors. Results: Forty-four percent of patients with WCH/E had moderate-severe WMH compared to 17% of normotensives (p = 0.047). The regression model with WMH as the dependent factor, and WCH/E and cardiovascular risk factors as independent factors showed WCH/E and either CAVI or PWV to be the only independent significant factor contributing to WMH (CAVI:p = 0.038, PWV:p = 0.043)

Enhancements to the STAGS computer code

The power of the STAGS family of programs was greatly enhanced. Members of the family include STAGS-C1 and RRSYS. As a result of improvements implemented, it is now possible to address the full collapse of a structural system, up to and beyond critical points where its resistance to the applied loads vanishes or suddenly changes. This also includes the important class of problems where a multiplicity of solutions exists at a given point (bifurcation), and where until now no solution could be obtained along any alternate (secondary) load path with any standard production finite element code

The uncoupling limit of identical Hopf bifurcations with an application to perceptual bistability

We study the dynamics arising when two identical oscillators are coupled near a Hopf bifurcation where we assume a parameter $\epsilon$ uncouples the system at $\epsilon=0$. Using a normal form for $N=2$ identical systems undergoing Hopf bifurcation, we explore the dynamical properties. Matching the normal form coefficients to a coupled Wilson-Cowan oscillator network gives an understanding of different types of behaviour that arise in a model of perceptual bistability. Notably, we find bistability between in-phase and anti-phase solutions that demonstrates the feasibility for synchronisation to act as the mechanism by which periodic inputs can be segregated (rather than via strong inhibitory coupling, as in existing models). Using numerical continuation we confirm our theoretical analysis for small coupling strength and explore the bifurcation diagrams for large coupling strength, where the normal form approximation breaks down

Curvature Radiation in Rotating Pulsar Magnetosphere

We consider the curvature emission properties from relativistic particles streaming along magnetic field lines and co-rotating with pulsar magnetosphere. The co-rotation affects the trajectories of the particles and hence the emission properties, especially the polarization. We consider the modification of the particle velocity and acceleration due to the co-rotation. Curvature radiation from a single particle is calculated using the approximation of a circular path to the particle trajectory. Curvature radiation from particles at a given height actually contains the contributions from particles streaming along all the nearby field lines around the tangential point, forming the emission cone of 1/{\gamma}. The polarization patterns from the emission cone are distorted by the additional rotation, more serious for emission from a larger height. Net circular polarization can be generated by the density gradient in the emission cone. For three typical density models in the form of core, cone and patches, we calculate the polarization profiles for emission generated at a given height. We find that the circular polarization could have a single sign or sign reversal, depending on the density gradient along the rotation phase. The polarization profiles of the total curvature radiation from the whole open field line region, calculated by adding the emission from all possible heights, are similar to that from a dominating emission height. The circular polarization of curvature radiation has sign reversals in the patchy emission, while it has a single sign for the core emission, and is negligible for the cone emission.Comment: 13pages,20figure

On the ratio of consecutive gaps between primes

In the present work we prove a common generalization of Maynard-Tao's recent result about consecutive bounded gaps between primes and on the Erd\H{o}s-Rankin bound about large gaps between consecutive primes. The work answers in a strong form a 60 years old problem of Erd\"os, which asked whether the ratio of two consecutive primegaps can be infinitely often arbitrarily small, and arbitrarily large, respectively

Is pulsar B0656+14 a very nearby RRAT source?

The recently discovered RRAT sources are characterized by very bright radio bursts which, while being periodically related, occur infrequently. We find bursts with the same characteristics for the known pulsar B0656+14. These bursts represent pulses from the bright end of an extended smooth pulse-energy distribution and are shown to be unlike giant pulses, giant micropulses or the pulses of normal pulsars. The extreme peak-fluxes of the brightest of these pulses indicates that PSR B0656+14, were it not so near, could only have been discovered as an RRAT source. Longer observations of the RRATs may reveal that they, like PSR B0656+14, emit weaker emission in addition to the bursts.Comment: 4 pages, 4 figures, accepted by ApJ