Mef2 induction of the immediate early gene Hr38/Nr4a is terminated by Sirt1 to promote ethanol tolerance.

Drug naïve animals given a single dose of ethanol show changed responses to subsequent doses, including the development of ethanol tolerance and ethanol preference. These simple forms of behavioral plasticity are due in part to changes in gene expression and neuronal properties. Surprisingly little is known about how ethanol initiates changes in gene expression or what the changes do. Here we demonstrate a role in ethanol plasticity for Hr38, the sole Drosophila homolog of the mammalian Nr4a1/2/3 class of immediate early response transcription factors. Acute ethanol exposure induces transient expression of Hr38 and other immediate early neuronal activity genes. Ethanol activates the Mef2 transcriptional activator to induce Hr38, and the Sirt1 histone/protein deacetylase is required to terminate Hr38 induction. Loss of Hr38 decreases ethanol tolerance and causes precocious but short-lasting ethanol preference. Similarly, reduced Mef2 activity in all neurons or specifically in the mushroom body α/β neurons decreases ethanol tolerance; Sirt1 promotes ethanol tolerance in these same neurons. Genetically decreasing Hr38 expression levels in Sirt1 null mutants restores ethanol tolerance, demonstrating that both induction and termination of Hr38 expression are important for behavioral plasticity to proceed. These data demonstrate that Hr38 functions as an immediate early transcription factor that promotes ethanol behavioral plasticity

JPL Ephemeris Tapes E9510, E9511, and E9512

The first issue of JPL Ephemeris Tapes is described. These tapes carry the positions and velocities of the planets and of the Moon, plus nutations and nutation rates in longitude and obliquity, together with second and fourth modified differences, for the interval December 30, 1949, to January 5, 2000

A semismooth Newton method for implicitly constituted non-Newtonian fluids and its application to the numerical approximation of Bingham flow

We propose a semismooth Newton method for non-Newtonian models of incompressible flow where the constitutive relation between the shear stress and the symmetric velocity gradient is given implicitly; this class of constitutive relations captures for instance the models of Bingham and Herschel-Bulkley. The proposed method avoids the use of variational inequalities and is based on a particularly simple regularisation for which the (weak) convergence of the approximate stresses is known to hold. The system is analysed at the function space level and results in mesh-independent behaviour of the nonlinear iterations.Comment: 25 page

Capture and release of a conditional state of a cavity QED system by quantum feedback

Detection of a single photon escaping an optical cavity QED system prepares a nonclassical state of the electromagnetic field. The evolution of the state can be modified by changing the drive of the cavity. For the appropriate feedback, the conditional state can be captured (stabilized) and then released. This is observed by a conditional intensity measurement that shows suppression of vacuum Rabi oscillations for the length of the feedback pulse and their subsequent return

Steady State Entanglement in Cavity QED

We investigate steady state entanglement in an open quantum system, specifically a single atom in a driven optical cavity with cavity loss and spontaneous emission. The system reaches a steady pure state when driven very weakly. Under these conditions, there is an optimal value for atom-field coupling to maximize entanglement, as larger coupling favors a loss port due to the cavity enhanced spontaneous emission. We address ways to implement measurements of entanglement witnesses and find that normalized cross-correlation functions are indicators of the entanglement in the system. The magnitude of the equal time intensity-field cross correlation between the transmitted field of the cavity and the fluorescence intensity is proportional to the concurrence for weak driving fields.Comment: enhanced discussion, corrected formulas, title change, 1 added figur