Some effects of thermal-cycle-induced deformation in rocket thrust chambers

The deformation process observed in the hot gas side wall of rocket combustion chambers was investigaged for three different liner materials. Five thrust chambers were cycled to failure by using hydrogen and oxygen as propellants at a chamber pressure of 4.14 MN/cu m. The deformation was observed nondestructively at midlife points and destructively after failure occurred. The cyclic life results are presented with an accompanying discussion about the problems of life prediction associated with the types of failures encountered in the present work. Data indicating the deformation of the thrust chamber liner as cycles are accumulated are presented for each of the test thrust chambers. From these deformation data and observation of the failure sites it is evident that modeling the failure process as classic low cycle thermal fatigue is inadequate as a life prediction method

Interactive tools for functional annotation of bacterial genomes

Automated annotations of protein functions are error-prone because of our lack of knowledge of protein functions. For example, it is often impossible to predict the correct substrate for an enzyme or a transporter. Furthermore, much of the knowledge that we do have about the functions of proteins is missing from the underlying databases. We discuss how to use interactive tools to quickly find different kinds of information relevant to a protein's function. Many of these tools are available via PaperBLAST (http://papers.genomics.lbl.gov). Combining these tools often allows us to infer a protein's function. Ideally, accurate annotations would allow us to predict a bacterium's capabilities from its genome sequence, but in practice, this remains challenging. We describe interactive tools that infer potential capabilities from a genome sequence or that search a genome to find proteins that might perform a specific function of interest. Database URL: http://papers.genomics.lbl.gov

Word Length Perturbations in Certain Symmetric Presentations of Dihedral Groups

Given a finite group with a generating subset there is a well-established notion of length for a group element given in terms of its minimal length expression as a product of elements from the generating set. Recently, certain quantities called $\lambda_{1}$ and $\lambda_{2}$ have been defined that allow for a precise measure of how stable a group is under certain types of small perturbations in the generating expressions for the elements of the group. These quantities provide a means to measure differences among all possible paths in a Cayley graph for a group, establish a group theoretic analog for the notion of stability in nonlinear dynamical systems, and play an important role in the application of groups to computational genomics. In this paper, we further expose the fundamental properties of $\lambda_{1}$ and $\lambda_{2}$ by establishing their bounds when the underlying group is a dihedral group. An essential step in our approach is to completely characterize so-called symmetric presentations of the dihedral groups, providing insight into the manner in which $\lambda_{1}$ and $\lambda_{2}$ interact with finite group presentations. This is of interest independent of the study of the quantities $\lambda_{1},\; \lambda_{2}$. Finally, we discuss several conjectures and open questions for future consideration

Electrical switching of magnetic polarity in a multiferroic BiFeO3 device at room temperature

We have directly imaged reversible electrical switching of the cycloidal rotation direction (magnetic polarity) in a (111)-BiFeO3 epitaxial-film device at room temperature by non-resonant x-ray magnetic scattering. Consistent with previous reports, fully relaxed (111)-BiFeO3 epitaxial films consisting of a single ferroelectric domain were found to comprise a sub-micron-scale mosaic of magneto-elastic domains, all sharing a common direction of the magnetic polarity, which was found to switch reversibly upon reversal of the ferroelectric polarization without any measurable change of the magneto-elastic domain population. A real-space polarimetry map of our device clearly distinguished between regions of the sample electrically addressed into the two magnetic states with a resolution of a few tens of micron. Contrary to the general belief that the magneto-electric coupling in BiFeO3 is weak, we find that electrical switching has a dramatic effect on the magnetic structure, with the magnetic moments rotating on average by 90 degrees at every cycle.Comment: 6 pages, 5 figures; corrected figure

Electrocardiographic safety evaluation of dihydroartemisinin piperaquine in the treatment of uncomplicated falciparum malaria.

Dihydroartemisinin-piperaquine (DP) could become a leading fixed combination malaria treatment worldwide. Although there is accumulating evidence of efficacy and safety from clinical trials, data on cardiotoxicity are limited. In two randomized controlled trials in Thailand, 56 patients had ECGs performed before treatment, 4 hours after the first dose, and 4 hours after the last dose. The mean (95% CI) changes in QTc interval (Bazett's correction) were 2 (-6 to 9) ms and 14 (7 to 21) ms, respectively. These small changes on the third day of treatment are similar to those observed elsewhere in the convalescent phase following antimalarial treatment with drugs known to have no cardiac effects and are therefore likely to result from recovery from acute malaria and not the treatment given. At therapeutic doses, DP does not have clinically significant effects on the electrocardiogram

Van der Waals Frictional Drag induced by Liquid Flow in Low- Dimensional Systems

We study the van der Waals frictional drag force induced by liquid flow in low-dimensional systems (2D and 1D electron systems, and 2D and 1D channels with liquid). We find that for both 1D and 2D systems, the frictional drag force induced by liquid flow may be several orders of magnitude larger than the frictional drag induced by electronic current.Comment: 10 pages, 4 figure

A discontinuity in the low-mass initial mass function

The origin of brown dwarfs (BDs) is still an unsolved mystery. While the standard model describes the formation of BDs and stars in a similar way recent data on the multiplicity properties of stars and BDs show them to have different binary distribution functions. Here we show that proper treatment of these uncovers a discontinuity of the multiplicity-corrected mass distribution in the very-low-mass star (VLMS) and BD mass regime. A continuous IMF can be discarded with extremely high confidence. This suggests that VLMSs and BDs on the one hand, and stars on the other, are two correlated but disjoint populations with different dynamical histories. The analysis presented here suggests that about one BD forms per five stars and that the BD-star binary fraction is about 2%-3% among stellar systems.Comment: 14 pages, 11 figures, uses emulateapj.cls. Minor corrections and 1 reference added after being accepted by the Ap

The quantized Hall conductance of a single atomic wire: A proposal based on synthetic dimensions

We propose a method by which the quantization of the Hall conductance can be directly measured in the transport of a one-dimensional atomic gas. Our approach builds on two main ingredients: (1) a constriction optical potential, which generates a mesoscopic channel connected to two reservoirs, and (2) a time-periodic modulation of the channel, specifically designed to generate motion along an additional synthetic dimension. This fictitious dimension is spanned by the harmonic-oscillator modes associated with the tightly-confined channel, and hence, the corresponding "lattice sites" are intimately related to the energy of the system. We analyze the quantum transport properties of this hybrid two-dimensional system, highlighting the appealing features offered by the synthetic dimension. In particular, we demonstrate how the energetic nature of the synthetic dimension, combined with the quasi-energy spectrum of the periodically-driven channel, allows for the direct and unambiguous observation of the quantized Hall effect in a two-reservoir geometry. Our work illustrates how topological properties of matter can be accessed in a minimal one-dimensional setup, with direct and practical experimental consequences.