A DESCRIPTIVE STUDY OF SERVICES RENDERED BY E-COMMERCE AND THEIR INNOVATIONS IN TECHNOLOGY ADOPTION TOWARDS AGRICULTURE SECTOR

E-Commerce is commercial transactions conducted electronically on the Internet. E-commerce (electronic commerce or EC) is the buying and selling of goods and services, or the transmitting of funds or data, over an electronic network, primarily the internet. These business transactions occur either as business-to-business, business-to-consumer, consumer-to-consumer or consumer-to-business. There are a lot of innovations in e-commerce which took place in recent years. The benefits of e-commerce include its around-the-clock availability, the speed of access, the wide availability of goods and services for the consumer, easy accessibility, and international reach. The technology adopted has also gone through a lot of changes. The technology advancements in e-commerce have been discussed in the study.  The main objective of the study is to analyze the advantages of adopting E-Commerce in agricultural sector and to know the advancement in technology adoption. Agriculture is the cultivation and breeding of animals, plants and fungi for food, fiber, bio fuel, medicinal plants and other products used to sustain and enhance human life. As agriculture plays a major role for the country to develop. The study clearly helps farmers to farm with less input and gain adequate output using e-commerce. It helps farmers to shop online from where ever they are for irrigation like purchasing seeds, fertilizers and search for markets for their output. Descriptive type of research is used for the study. The data gathered is primary as well as secondary. Websites, books, journals are the sources used for data gathering. Formulation of hypothesis, objectives, advantages and limitations have been discussed in the study

Effects of cross-correlations in 2D NOE experiments

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Cross-correlations in NMR

The phenomenon of nuclear magnetic resonance (NMR) involves placing magnetically active nuclear spins embedded in a gas, liquid or solid phase in a constant, large and uniform magnetic field, causing a splitting of magnetic energy levels.Energy can be absorbed by these spins from a resonant radiofrequency (RF) field causing transitions between these levels. Immediately following this absorption, the spins start to exchange this energy among themselves and also pass it on to other degrees of freedom, that is, the spins start to relax. Relaxation is central to the NMR phenomenon as a necessary prerequisite for its detection. It is also used as a probe for obtaining information on the local environment of the spins and about the dynamics of the molecules in which the spins are embedded

Hepatotoxicity of Microcystis aeruginosa Strains Growing as Blooms in Certain Eutrophic Ponds

Critical assessment of five eutrophicated ponds of Varanasi city (India) revealed the presence of heavy blooms of cyanobacteria consisting mainly of Microcystis aeruginosa. Crude aqueous extracts of blooms as well as laboratory grown M. aeruginosa isolated from three ponds, namely Lakshmikund, Durgakund and Adityanagar showed toxicity in mouse bioassay test. Crude aqueous extracts from these samples caused death of test mice within 1h of administration (i.p.) with a LD50 of 60 mg/kg body weight and the treated animals showed clinical signs of hepatotoxicity. However such an effect was not associated with the blooms from Laatbhairov and Surajkund ponds suggesting that not all strains of M. aeruginosa are toxic. Based on spectral properties (?max 230 nm), and comparison with standard microcystin-LR, the toxin is tentatively identified as microcystin-LR. The purified toxin caused death of test mice within 40 min of its administration with a LD50 of 100 µg/ kg body weight and induced gross morphological and functional changes in liver. A 1.55 fold increase in liver weight accompanied by deep red coloration most probably due to hemorrhage and blood pooling suggested the hepatotoxic properties of the toxin. Hepatotoxicity was also evident from the drastic increase (up to 2.5 fold) in activity of serum enzymes such as glutamate pyruvate transaminase/alanine aminotransferase (GPT/ALT), lactate dehydrogenase (LDH) and alkaline phosphatase (APase) following toxin treatment. ^14C-labelling experiments demonstrated maximum accumulation (~15%) of ^14C- toxin after 20 min. of toxin administration. Appreciable level of toxin was also detected in water of four ponds. In conclusion these results clearly demonstrate that microcystin-producing blooms of M. aeruginosa are common in eutrophicated ponds of Varanasi city but not all ponds harbour toxic blooms

Molecular Mechanisms of Ultraviolet Radiation-Induced DNA Damage and Repair

DNA is one of the prime molecules, and its stability is of utmost importance for proper functioning and existence of all living systems. Genotoxic chemicals and radiations exert adverse effects on genome stability. Ultraviolet radiation (UVR) (mainly UV-B: 280–315 nm) is one of the powerful agents that can alter the normal state of life by inducing a variety of mutagenic and cytotoxic DNA lesions such as cyclobutane-pyrimidine dimers (CPDs), 6-4 photoproducts (6-4PPs), and their Dewar valence isomers as well as DNA strand breaks by interfering the genome integrity. To counteract these lesions, organisms have developed a number of highly conserved repair mechanisms such as photoreactivation, base excision repair (BER), nucleotide excision repair (NER), and mismatch repair (MMR). Additionally, double-strand break repair (by homologous recombination and nonhomologous end joining), SOS response, cell-cycle checkpoints, and programmed cell death (apoptosis) are also operative in various organisms with the expense of specific gene products. This review deals with UV-induced alterations in DNA and its maintenance by various repair mechanisms

In vitro effect of Withania somnifera, AYUSH-64, and remdesivir on the activity of CYP-450 enzymes: Implications for possible herb−drug interactions in the management of COVID-19

Ayurvedic medicines Withania somnifera Dunal (ashwagandha) and AYUSH-64 have been used for the prevention and management of COVID-19 in India. The present study explores the effect of Ashwagandha and AYUSH-64 on important human CYP enzymes (CYP3A4, CYP2C8, and CYP2D6) to assess their interaction with remdesivir, a drug used for COVID-19 management during the second wave. The study also implies possible herb−drug interactions as ashwagandha and AYUSH-64 are being used for managing various pathological conditions. Aqueous extracts of ashwagandha and AYUSH-64 were characterized using LC-MS/MS. A total of 11 and 24 phytoconstituents were identified putatively from ashwagandha and AYUSH-64 extracts, respectively. In addition, in silico studies revealed good ADME properties of most of the phytoconstituents of these herbal drugs and suggested that some of these might possess CYP-450 inhibitory activity. In vitro CYP-450 studies with human liver microsomes showed moderate inhibition of CYP3A4, 2C8, and 2D6 by remdesivir, while ashwagandha had no inhibitory effect alone or in combination with remdesivir. AYUSH-64 also exhibited a similar trend; however, a moderate inhibitory effect on CYP2C8 was noticed. Thus, ashwagandha seems to be safe to co-administer with the substrates of CYP3A4, CYP2C8, and CYP2D6. However, caution is warranted in prescribing AYUSH-64 along with CYP2C8 substrate drugs. Furthermore, preclinical and clinical PK studies would be helpful for their effective and safer use in the management of various ailments along with other drugs

A Self Learning based Diagnosis of Faulty Configurable Logic Blocks (CLBs) in Field Programmable Gate Arrays (FPGA) Using Reconfiguration

In many areas of digital systems Field programmable gate arrays (FPGAs) are most important for designing. The main usesof FPGAs are, these are programmable, and faults can be easily diagnosed, once faulty locations are identified. The locationand identification of faults in FPGA has not yet been explored much. A methodology for the testing and diagnosis of faultsin FPGAs is presented based on automatic circuit reconfiguration. The proposed method imposes no hardware overhead.This method can also be used in fault-tolerant systems, in which a good functional circuit can be still mapped to a FPGAwith faulty elements, as long as the fault sites are known. The logic synthesis software assigns the Configurable Logic Block(CLB) resources without system designer intervention. It is very advantageous for the designer to understand certain CLBdetails, including the varying capabilities of the look-up tables (LUTs), the physical direction of the carry propagation, thenumber and distribution of the available flip-flops. FPGA consists of 25 Configurable Logic Blocks (CLB). Each CLB isassigned with an application. The inputs for CLB are applied from a file. There is also a fault file in which error CLBs arepresent. If there is error CLBs, those CLBs are replaced by the spare CLBs. Finally, the errors CLBs are corrected withproper inputs and modified bits are displayed. So efficiency is not reduced and configurability is done without replacing thefaulty components. This FPGA can tolerate not only single faults but also for multiple faults. The power analysis resultsprovided for fault free, stuck-at-1, stuck-at-0 faults in digital circuits validate the point that faulty circuits dissipates moreand hence draw more power.Key words: Configurable Logic Block (CLB), Power Dissipation, Fault Tolerance, Fault Diagnosis, Faults, Full adder (FA)

Efficient organic-inorganic hybrid perovskite solar cells processed in air

Organic-inorganic hybrid perovskite solar cells with fluorine doped tin oxide/titanium dioxide/CH3NH3PbI3-xClx/poly(3-hexylthiophene)/silver were made in air with more than 50% humidity. The best devices showed an open circuit voltage of 640 mV, a short circuit current density of 18.85 mA cm-2, a fill factor of 0.407 and a power conversion efficiency of 5.67%. The devices showed external quantum efficiency varying from 60 to 80% over a wavelength region of 350 nm to 750 nm of the solar spectrum. The morphology of the perovskite was investigated using scanning electron microscopy and it was found to be porous in nature. This study provides insights into air-stability of perovskite solar cells

Buccal films: A review of therapy possibilities, treatment plans and appropriate evaluation techniques

Due to apparent greater patient acceptance compared to buccal tablets and enormous therapeutic opportunities compared to traditional oral drug delivery methods, particularly for those who suffer from dysphagia, the potential of the mucoadhesive film technology is difficult to ignore. Despite this, there are currently no authorised mucoadhesive buccal films, and the translation of published literature into the commercial market is essentially non-existent. In order to help this patient-centred dosage form become more widely used, this review aims to give an overview of mucoadhesive buccal film technology and highlight crucial areas on which to concentrate scientific efforts. While discussing the patient-related aspects influencing the utilisation of various dosage forms, a number of indications and development potential were noted. A technical description of the processes used to create these films, including solvent casting, hot melt extrusion, inkjet printing, and three-dimensional printing, was also offered. The utilisation of more than thirty mucoadhesive polymers in film formulations was found, and information about their mucoadhesive properties as well as their inclusion with other essential formulation ingredients was supplied