Efficient Wage Subsidies in Private Firms and Deadweight Spending

This paper links the old literature on employment subsidies with the current theories of contract and regulation. One important source of inefficiency of employment subsidies is deadweight spending. This refers to the cases in which private firms receive a subsidy for employment creation that would have been reached without this financial support. We identify the asymmetry of information between the regulator and the private firm as the source of this deadweight spending. The private firm knows its hiring capability while the government does not. We then derive the optimal incentive contracts for the government. In these contracts deadweight spending is reduced to the information rent to private firms. We derive conditions for which this deadweight spending is zero.Contract-Theory; Principal-Agent; Economic-Policy; Employment-Subsidy; Cost-Benefit-Analysis

Preventing pain on injection of propofol: A comparison between lignocaine pre-treatment and lignocaine added to propofol

Publisher's copy made available with the permission of the publisherA randomized double-blind study compared two methods of preventing the pain from injection of propofol, lignocaine pre-treatment followed by propofol and lignocaine added to propofol. One hundred patients received a 4 ml solution intravenously with a venous tourniquet for 1 minute, followed by propofol mixed with 2 ml of solution. Patients were divided into two treatment groups of 50 patients each: 4 ml 1% lignocaine pre-treatment followed by propofol and 2 ml saline, or 4 ml saline followed by propofol and 2 ml 2% lignocaine. Pain was assessed with a 100 mm visual analogue scale after induction and in recovery. The incidence of injection pain was 8% in the propofol mixed with lignocaine group, and 28% in the lignocaine pre-treatment group. This difference is statistically significant (P=0.017). For those patients who had pain, the mean pain score was 26.5 on induction for the propofol with lignocaine group (n=4), while the mean score was 44.4 for the pre-treatment group (n=13). The difference was not statistically significant (P=0.25). None of the propofol mixed with lignocaine group recalled pain, while 13 of the pre-treatment group did so. Lignocaine pre-treatment does not improve the immediate or the recalled comfort of patients during propofol induction when compared to lignocaine added to propofol. It is recommended that lignocaine should be added to propofol for induction rather than given before induction.P. Lee, W. J. Russellhttp://www.aaic.net.au/Article.asp?D=200339

Characterization of a dense aperture array for radio astronomy

EMBRACE@Nancay is a prototype instrument consisting of an array of 4608 densely packed antenna elements creating a fully sampled, unblocked aperture. This technology is proposed for the Square Kilometre Array and has the potential of providing an extremely large field of view making it the ideal survey instrument. We describe the system,calibration procedures, and results from the prototype.Comment: 17 pages, accepted for publication in A&

Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation

BRCA1 plays an important role in mechanisms of response to double-strand breaks, participating in genome surveillance, DNA repair, and cell cycle checkpoint arrests. Here, we identify a constitutive BRCA1-c-Abl complex and provide evidence for a direct interaction between the PXXP motif in the C terminus of BRCA1 and the SH3 domain of c-Abl. Following exposure to ionizing radiation (IR), the BRCA1-c-Abl complex is disrupted in an ATM-dependent manner, which correlates temporally with ATM-dependent phosphorylation of BRCA1 and ATM-dependent enhancement of the tyrosine kinase activity of c-Abl. The BRCA1-c-Abl interaction is affected by radiation-induced modification to both BRCA1 and c-Abl. We show that the C terminus of BRCA1 is phosphorylated by c-Abl in vitro. In vivo, BRCA1 is phosphorylated at tyrosine residues in an ATM-dependent, radiation-dependent manner. Tyrosine phosphorylation of BRCA1, however, is not required for the disruption of the BRCA1-c-Abl complex. BRCA1-mutated cells exhibit constitutively high c-Abl kinase activity that is not further increased on exposure to IR. We suggest a model in which BRCA1 acts in concert with ATM to regulate c-Abl tyrosine kinase activity

Distributed Minimum Cut Approximation

We study the problem of computing approximate minimum edge cuts by distributed algorithms. We use a standard synchronous message passing model where in each round, $O(\log n)$ bits can be transmitted over each edge (a.k.a. the CONGEST model). We present a distributed algorithm that, for any weighted graph and any $\epsilon \in (0, 1)$, with high probability finds a cut of size at most $O(\epsilon^{-1}\lambda)$ in $O(D) + \tilde{O}(n^{1/2 + \epsilon})$ rounds, where $\lambda$ is the size of the minimum cut. This algorithm is based on a simple approach for analyzing random edge sampling, which we call the random layering technique. In addition, we also present another distributed algorithm, which is based on a centralized algorithm due to Matula [SODA '93], that with high probability computes a cut of size at most $(2+\epsilon)\lambda$ in $\tilde{O}((D+\sqrt{n})/\epsilon^5)$ rounds for any $\epsilon>0$. The time complexities of both of these algorithms almost match the $\tilde{\Omega}(D + \sqrt{n})$ lower bound of Das Sarma et al. [STOC '11], thus leading to an answer to an open question raised by Elkin [SIGACT-News '04] and Das Sarma et al. [STOC '11]. Furthermore, we also strengthen the lower bound of Das Sarma et al. by extending it to unweighted graphs. We show that the same lower bound also holds for unweighted multigraphs (or equivalently for weighted graphs in which $O(w\log n)$ bits can be transmitted in each round over an edge of weight $w$), even if the diameter is $D=O(\log n)$. For unweighted simple graphs, we show that even for networks of diameter $\tilde{O}(\frac{1}{\lambda}\cdot \sqrt{\frac{n}{\alpha\lambda}})$, finding an $\alpha$-approximate minimum cut in networks of edge connectivity $\lambda$ or computing an $\alpha$-approximation of the edge connectivity requires $\tilde{\Omega}(D + \sqrt{\frac{n}{\alpha\lambda}})$ rounds

Female Blow Flies As Vertebrate Resource Indicators

Rapid vertebrate diversity evaluation is invaluable for monitoring changing ecosystems worldwide. Wild blow flies naturally recover DNA and chemical signatures from animal carcasses and feces. We demonstrate the power of blow flies as biodiversity monitors through sampling of flies in three environments with varying human influences: Indianapolis, IN and two national parks (the Great Smoky Mountains and Yellowstone). Dissected fly guts underwent vertebrate DNA sequencing (12S and 16S rRNA genes) and fecal metabolite screening. Integrated Nested Laplace Approximation (INLA) was used to determine the most important abiotic factor influencing fly-derived vertebrate richness. In 720 min total sampling time, 28 vertebrate species were identified, with 42% of flies containing vertebrate resources: 23% DNA, 5% feces, and 14% contained both. The species of blow fly used was not important for vertebrate DNA recovery, however the use of female flies versus male flies directly influenced DNA detection. Temperature was statistically relevant across environments in maximizing vertebrate detection (mean = 0.098, sd = 0.048). This method will empower ecologists to test vertebrate community ecology theories previously out of reach due practical challenges associated with traditional sampling

Pulsed laser ignition of reactive multilayer films

Nanostructured Al/PtAl∕Pt multilayer films were ignited by single pulse irradiation from a Ti:sapphire femtosecond laser system. Critical ignition fluences (0.9–22 J/cm2)(0.9–22J∕cm2) required to initiate a self-propagating reaction were quantified for different multilayer designs. Multilayers with smaller bilayer thickness required relatively lower fluence for ignition. Ignition threshold fluence was also found to be 1.4–3.6 times higher for Al-capped multilayers than for Pt-capped multilayers. Ablation threshold fluences were measured for Al (860±70 mJ/cm2)(860±70mJ∕cm2) and Pt (540±50 mJ/cm2)(540±50mJ∕cm2) and related to the observed difference in ignition fluences for Al- and Pt-capped multilayers.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87770/2/144102_1.pd

Closed trajectories of a particle model on null curves in anti-de Sitter 3-space

We study the existence of closed trajectories of a particle model on null curves in anti-de Sitter 3-space defined by a functional which is linear in the curvature of the particle path. Explicit expressions for the trajectories are found and the existence of infinitely many closed trajectories is proved.Comment: 12 pages, 1 figur

Role of a native oxide on femtosecond laser interaction with silicon (100) near the damage threshold

Si (100) with and without a 14–25 Å14–25Å thick native oxide was laser machined at grazing incidence using a Ti:sapphire femtosecond pulsed laser under ultrahigh vacuum conditions. The resulting damage feature size and morphology indicate that the presence or absence of the native oxide significantly affects the mechanism for femtosecond laser-induced damage. We propose that a fluence-dependent modification of the oxide by the incident laser pulse must be considered when studying femtosecond laser damage of Si (100) with a native oxide. Data are also presented that are consistent with a dose-dependent phase transformation in the amorphous oxide. The implications of the native oxide, including relative damage thresholds of the underlying Si (100) and the role of the oxide in damage morphology are addressed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87851/2/264103_1.pd