Dynamics of a lattice Universe

We find a solution to Einstein field equations for a regular toroidal lattice of size L with equal masses M at the centre of each cell; this solution is exact at order M/L. Such a solution is convenient to study the dynamics of an assembly of galaxy-like objects. We find that the solution is expanding (or contracting) in exactly the same way as the solution of a Friedman-Lema\^itre-Robertson-Walker Universe with dust having the same average density as our model. This points towards the absence of backreaction in a Universe filled with an infinite number of objects, and this validates the fluid approximation, as far as dynamics is concerned, and at the level of approximation considered in this work.Comment: 14 pages. No figure. Accepted version for Classical and Quantum Gravit

The Role of Choice in Weight Loss Strategies: A Systematic Review and Meta-Analysis

Effective strategies to achieve weight loss and long-term weight loss maintenance have proved to be elusive. This systematic review and meta-analysis aims to explore whether the choice of weight loss strategy is associated with greater weight loss. An electronic search was conducted using the MEDLINE (Medical Literature Analysis and Retrieval System Online, or MEDLARS Online), EMBASE (Excerpta Medica database), CINAHL (Cumulative Index to Nursing and Allied Health Literature), and PsycINFO (Database of Abstracts of Literature in the Field of Psychology, produced by the American Psychological Association and distributed on the association’s APA PsycNET) databases for clinical trials and randomized controlled trials, investigating the role of choice in weight loss strategies. A total of nine studies were identified as meeting the pre-specified criteria. All of the studies included a ‘Choice’ or preference arm and a ‘No Choice’ arm or group who did not receive their preference as a control. A total of 1804 subjects were enrolled in these studies, with weight loss observed in both experimental and control groups of all studies, irrespective of dietary intervention, study duration, or follow-up length. Twelve interventions in nine trials were used for the meta-analysis, with results indicating a greater weight loss in the control groups, 1.09 ± 0.28 (overall mean difference in weight loss between groups ± standard error; p = 0). There was no significant effect of duration or attrition. In this meta-analysis, the choice of weight loss strategy did not confer a weight loss benefit. © 2018 by the authors. Licensee MDPI, Basel, Switzerland

The Method of Images in Cosmology

31 pages, 18 figures31 pages, 18 figuresWe apply the method of images to the exact initial data for cosmological models that contain a number of regularly arranged discrete masses. This allows us to join cosmological regions together by throats, and to construct wormholes in the initial data. These wormholes allow for the removal of the asymptotically flat "flange" regions that would otherwise exist on the far side of black holes. The method of images also provides us with a way to investigate the definition of mass is cosmology, and the cosmological consequences of the gravitational interaction energies between massive objects. We find evidence that the interaction energies within clusters of massive objects do indeed appear to contribute to the total energy budget in the cosmological regions of the space-time

Cosmological solutions with charged black holes

RB aknowledges support from the Higher Education Commission (HEC) of Pakistan, which provided funding to visit QMUL while this work was performed. TC and JD are supported by the STFC

Weight loss and attrition in overweight and obese young women during a 36- week internet-based lifestyle intervention

Background: Young women are at high risk of weight gain yet few studies have examined the long-term effectiveness of weight loss programs in this group. This study aimed to investigate the effects of a self-directed internet-based lifestyle program on body weight in young women.Methods: Overweight or obese young women (BMI 33.4 ± 0.3 kg/m2, age 27.8 ± 0.3 years) were initially randomized to General lifestyle advice (G) or Structured lifestyle advice (S) via in-person and website support for 12 weeks (Phase I). After Phase I, all participants were supported through a self-directed internet-based program for 36 weeks (Phase II). The internet-based program included a structured hypocaloric diet, physical activity program, self-monitoring tools, peer group forum and monthly emails. Body weight, energy intake and physical activity were measured at week 0, week 12, week 24 and week 48. Adherence to self-regulatory behaviors was measured at week 48. Mixed model analyses were conducted to determine changes in body weight, energy intake and physical activity.Results: A total of 203 overweight or obese young women commenced Phase I and 130 commenced Phase II. In Phase I, S group had significantly greater weight loss than G group (4.2 ± 0.6 kg vs 0.6 ± 0.3 kg, P<0.001). In Phase II, both groups had significant weight loss over time without significant group differences (-0.8 ± 1.1kg vs -0.8 ± 0.6, P>0.05). Forty-one percent (53/130) of the participants who commenced Phase II completed the internet-based intervention. Dropouts had a higher baseline BMI, were more likely to be married or in a de facto relationship, and more likely to have at least one child.Conclusions: A self-directed internet-based program could be effective in providing support in maintaining weight loss on a structured lifestyle program in young women over 36 weeks. Further research is required to maintain engagement in young women who were married/in a de facto relationship or have children

A quasi-static approach to structure formation in black hole universes

JD and TC both acknowledge support from the STFC under grant STFC ST/N504257/1

Web Bearing Capacity of Cold-Formed Ferritic Stainless Steel Unlipped Channels with Web perforations under the End-Two-Flange (ETF) Loading

Laboratory and numerical evaluations on the web bearing capacity of unlipped cold-formed ferritic stainless steel channels are described in this paper. The channels considered have circular perforations in the web and are loaded under the end-two-flange (ETF) load case. A total of 387 results comprising 27 laboratory and 360 numerical results are presented. A nonlinear quasi-static finite element (FE) model was developed for the numerical investigation. An extensive parametric study is described to determine web bearing capacity reduction factors for different sizes of circular web perforations and cross-section dimensions; the circular web perforations are either centred or offset to the load and reaction plates. It is noted that no cold-formed stainless steel standard provides capacity reduction factors for any end-two-flange load case. The capacity reduction factor equations are first compared to reduction factors previously recommended for lipped cold-formed stainless steel channels. It is found that these existing equations are unreliable and unconservative for unlipped channels by as much as 11%. From both laboratory and finite element results, web bearing capacity design equations are proposed for both sections, with and without web perforations

Web Crippling Behavior of Cold-Formed Ferritic Stainless Steel Unlipped Channels under Interior-One-Flange And End-One-Flange Loadings

The web crippling strength of cold-formed ferritic stainless steel unlipped channels subject to interior-one-flange and end-one-flange loading is considered in this paper. A total of 144 results are presented, comprising 36 laboratory and 108 numerical results. These results cover the cases of both flanges restrained and unrestrained to the load and reaction plates. Unlike other work in the literature, the numerical analysis in this paper uses nonlinear quasi-static finite element analysis with an implicit integration scheme, which has advantages over static and quasi-static with an explicit integration scheme analyses, particularly for post buckling predictions of unlipped channels subject to web crippling. The laboratory and numerical investigations show current stainless steel design guidance to be too conservative. In terms of design standards, while no cold-formed stainless steel standard distinguishes between flanges restrained and unrestrained to the load and reaction plates, with each standard providing only one equation to cover both restrained and unrestrained, the web crippling strengths for the flanges unrestrained case were found to be higher than those predicted from SEI/ASCE-8 by as much as 24%. Also, the web crippling strengths for the flanges restrained case are shown to be higher than those predicted from equations found in the literature by as much as 48%. New web crippling design equations are proposed; the proposed equations are shown to be reliable when compared against laboratory and numerical results

Investigating hookworm genomes by comparative analysis of two Ancylostoma species

Background Hookworms, infecting over one billion people, are the mostly closely related major human parasites to the model nematode Caenorhabditis elegans. Applying genomics techniques to these species, we analyzed 3,840 and 3,149 genes from Ancylostoma caninum and A. ceylanicum. Results Transcripts originated from libraries representing infective L3 larva, stimulated L3, arrested L3, and adults. Most genes are represented in single stages including abundant transcripts like hsp-20 in infective L3 and vit-3 in adults. Over 80% of the genes have homologs in C. elegans, and nearly 30% of these were with observable RNA interference phenotypes. Homologies were identified to nematode-specific and clade V specific gene families. To study the evolution of hookworm genes, 574 A. caninum / A. ceylanicum orthologs were identified, all of which were found to be under purifying selection with distribution ratios of nonsynonymous to synonymous amino acid substitutions similar to that reported for C. elegans / C. briggsae orthologs. The phylogenetic distance between A. caninum and A. ceylanicum is almost identical to that for C. elegans / C. briggsae. Conclusion The genes discovered should substantially accelerate research toward better understanding of the parasites' basic biology as well as new therapies including vaccines and novel anthelmintics

Bipartite Mixed States of Infinite-Dimensional Systems are Generically Nonseparable

Given a bipartite quantum system represented by a tensor product of two Hilbert spaces, we give an elementary argument showing that if either component space is infinite-dimensional, then the set of nonseparable density operators is trace-norm dense in the set of all density operators (and the separable density operators nowhere dense). This result complements recent detailed investigations of separability, which show that when both component Hilbert spaces are finite-dimensional, there is a separable neighborhood (perhaps very small for large dimensions) of the maximally mixed state.Comment: 5 pages, RevTe