130 research outputs found
Second Backbend in the Mass A ~ 180 Region
Within the framework of selfconsistent cranked Hartree-Fock- Bogoliubov
theory(one-dimensional) we predict second backbend in the yrast line of Os-182
at , which is even sharper than the first one observed
experimentally at .
Around such a high spin the structure becomes multi-quasiparticle type, but
the main source of this strong discontinuity is a sudden large alignment of
i_13/2 proton orbitals along the rotation axis followed soon by the alignment
of j_15/2 neutron orbitals. This leads to drastic structural changes at such
high spins. When experimentally confirmed, this will be observed for the first
time in this mass region, and will be at the highest spin so far.Comment: 13 pages, 4 ps figure
Shape and blocking effects on odd-even mass differences and rotational motion of nuclei
Nuclear shapes and odd-nucleon blockings strongly influence the odd-even
differences of nuclear masses. When such effects are taken into account, the
determination of the pairing strength is modified resulting in larger pair
gaps. The modified pairing strength leads to an improved self-consistent
description of moments of inertia and backbending frequencies, with no
additional parameters.Comment: 7 pages, 3 figures, subm to PR
Au-Ag template stripped pattern for scanning probe investigations of DNA arrays produced by Dip Pen Nanolithography
We report on DNA arrays produced by Dip Pen Nanolithography (DPN) on a novel
Au-Ag micro patterned template stripped surface. DNA arrays have been
investigated by atomic force microscopy (AFM) and scanning tunnelling
microscopy (STM) showing that the patterned template stripped substrate enables
easy retrieval of the DPN-functionalized zone with a standard optical
microscope permitting a multi-instrument and multi-technique local detection
and analysis. Moreover the smooth surface of the Au squares (abput 5-10
angstrom roughness) allows to be sensitive to the hybridization of the
oligonucleotide array with label-free target DNA. Our Au-Ag substrates,
combining the retrieving capabilities of the patterned surface with the
smoothness of the template stripped technique, are candidates for the
investigation of DPN nanostructures and for the development of label free
detection methods for DNA nanoarrays based on the use of scanning probes.Comment: Langmuir (accepted
The duration of intra-abdominal hypertension strongly predicts outcomes for the critically ill surgical patients: a prospective observational study
Identification and Localization of Proteins Associated with Biomineralization in the Iron Deposition Vesicles of Honeybees (Apis mellifera)
Honeybees (Apis mellifera) form superparamagnetic magnetite to act as a magnetoreceptor for magnetoreception. Biomineralization of superparamagnetic magnetite occurs in the iron deposition vesicles of trophocytes. Even though magnetite has been demonstrated, the mechanism of magnetite biomineralization is unknown. In this study, proteins in the iron granules and iron deposition vesicles of trophocytes were purified and identified by mass spectrometry. Antibodies against such proteins were produced. The major proteins include actin, myosin, ferritin 2, and ATP synthase. Immunolabeling and co-immunoprecipitation studies suggest that iron is stored in ferritin 2 for the purpose of forming 7.5-nm diameter iron particles and that actin-myosin-ferritin 2 may serve as a transporter system. This system, along with calcium and ATP, conveys the iron particles (ferritin) to the center of iron deposition vesicles for iron granules formation. These proteins and reactants are included in iron deposition vesicles during the formation of iron deposition vesicles from the fusion of smooth endoplasmic reticulum. A hypothetical model for magnetite biomineralization in iron deposition vesicles is proposed for honeybees
Endotoxaemia in Haemodialysis: A Novel Factor in Erythropoetin Resistance?
Background/Objectives
Translocated endotoxin derived from intestinal bacteria is a driver of systemic inflammation and oxidative stress. Severe endotoxaemia is an underappreciated, but characteristic finding in haemodialysis (HD) patients, and appears to be driven by acute repetitive dialysis induced circulatory stress. Resistance to erythropoietin (EPO) has been identified as a predictor of mortality risk, and associated with inflammation and malnutrition. This study aims to explore the potential link between previously unrecognised endotoxaemia and EPO Resistance Index (ERI) in HD patients.
Methodology/Principal Findings
50 established HD patients were studied at a routine dialysis session. Data collection included weight, BMI, ultrafiltration volume, weekly EPO dose, and blood sampling pre and post HD. ERI was calculated as ratio of total weekly EPO dose to body weight (U/kg) to haemoglobin level (g/dL). Mean haemoglobin (Hb) was 11.3±1.3 g/dL with a median EPO dose of 10,000 [IQR 7,500–20,000] u/wk and ERI of 13.7 [IQR 6.9–23.3] ((U/Kg)/(g/dL)). Mean pre-HD serum ET levels were significantly elevated at 0.69±0.30 EU/ml. Natural logarithm (Ln) of ERI correlated to predialysis ET levels (r = 0.324, p = 0.03) with a trend towards association with hsCRP (r = 0.280, p = 0.07). Ln ERI correlated with ultrafiltration volume, a driver of circulatory stress (r = 0.295, p = 0.046), previously identified to be associated with increased intradialytic endotoxin translocation. Both serum ET and ultrafiltration volume corrected for body weight were independently associated with Ln ERI in multivariable analysis.
Conclusions
This study suggests that endotoxaemia is a significant factor in setting levels of EPO requirement. It raises the possibility that elevated EPO doses may in part merely be identifying patients subjected to significant circulatory stress and suffering the myriad of negative biological consequences arising from sustained systemic exposure to endotoxin
Influence of two different levels of intra-abdominal hypertension on bacterial translocation in a porcine model
How does the media portray drinking water security in Indigenous communities in Canada? An analysis of Canadian newspaper coverage from 2000-2015
Pet Project or Best Project? Online Decision Support Tools for Prioritizing Barrier Removals in the Great Lakes and Beyond
Structures that block movement of fish through river networks are built to serve a variety of societal needs, including transportation, hydroelectric power, and exclusion of exotic species. Due to their abundance, road crossings and dams reduce the amount of habitat available to fish that migrate from the sea or lakes into rivers to breed. The benefits to fish of removing any particular barrier depends on its location within the river network, its passability to fish, and the relative position of other barriers within the network. Balancing the trade-offs between ecological and societal values makes choosing among potential removal projects difficult. To facilitate prioritization of barrier removals, we developed an online decision support tool (DST) with three functions: (1) view existing barriers at various spatial scales; (2) modify information about barriers, including removal costs; and (3) run optimization models to identify portfolios of removals that provide the greatest amount of habitat access for a given budget. A survey of available DSTs addressing barrier removal prioritization indicates that barrier visualization is becoming widespread but few tools allow dynamic calculation of connectivity metrics, scenario analysis, or optimization. Having these additional functions, our DST enables organizations to develop barrier removal priorities based on
cost-effectiveness in restoring aquatic connectivity
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