16 research outputs found
A Contribution to the Glimepiride Dissociation Constant Determination
No full textKnowledge of druglike properties, such as dissociation constants (pK(a)), is of great importance in drug development and analysis. However, poor aqueous Solubility often Causes serious limitations ill accurate determination of a drug's pK(a). In this Study, the apparent dissociation constant (pK(a)') of the poorly soluble drug, glimepiride, has been determined by application of the spectrophotometric and Solubility methods. Compared to the literature reported glimepiride pK(a)' values of 4.99 +/- 0.50 and 6.2 +/- 0.1, the values obtained in the present study were 8.07 +/- 0.02 and 7.26 +/- 0.01 determined by the spectrophotometric and Solubility method, respectively. In addition, the advantages of these two methods in pK(a)' determination of glimepiride are discussed
UHPLC-MS/MS method for analysis of sobuzoxane, its active form ICRF-154 and metabolite EDTA-diamide and its application to bioactivation study
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Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone
No full textMass Spectrometry Based Identification of Geometric Isomers during Metabolic Stability Study of a New Cytotoxic Sulfonamide Derivatives Supported by Quantitative Structure-Retention Relationships
No full textCharacterization of a Photoswitching Chelator with Light-Modulated Geometric, Electronic, and Metal-Binding Properties
No full textEffect of biosolid application to Mollisol Chilean soils on the bioavailability of heavy metals (Cu, Cr, Ni, and Zn) as assessed by bioassays with sunflower (Helianthus annuus) and DGT measurements
No full textAssessment of metals bioavailability to vegetables under field conditions using DGT, single extractions and multivariate statistics
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