2,312 research outputs found
The Role of Gut Adaptation in the Potent Effects of Multiple Bariatric Surgeries on Obesity and Diabetes
Bariatric surgical procedures such as vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) are the most potent treatments available to produce sustained reductions in body weight and improvements in glucose regulation. While traditionally these effects are attributed to mechanical aspects of these procedures, such as restriction and malabsorption, a growing body of evidence from mouse models of these procedures points to physiological changes that mediate the potent effects of these surgeries. In particular, there are similar changes in gut hormone secretion, bile acid levels, and composition after both of these procedures. Moreover, loss of function of the nuclear bile acid receptor (FXR) greatly diminishes the effects of VSG. Both VSG and RYGB are linked to profound changes in the gut microbiome that also mediate at least some of these surgical effects. We hypothesize that surgical rearrangement of the gastrointestinal tract results in enteroplasticity caused by the high rate of nutrient presentation and altered pH in the small intestine that contribute to these physiological effects. Identifying the molecular underpinnings of these procedures provides new opportunities to understand the relationship of the gastrointestinal tract to obesity and diabetes as well as new therapeutic strategies to harness the effectiveness of surgery with less-invasive approaches
Pole structure of the Hamiltonian -function for a singular potential
We study the pole structure of the -function associated to the
Hamiltonian of a quantum mechanical particle living in the half-line
, subject to the singular potential . We show that
admits nontrivial self-adjoint extensions (SAE) in a given range of values
of the parameter . The -functions of these operators present poles
which depend on and, in general, do not coincide with half an integer (they
can even be irrational). The corresponding residues depend on the SAE
considered.Comment: 12 pages, 1 figure, RevTeX. References added. Version to appear in
Jour. Phys. A: Math. Ge
Limited transfer and retention of locomotor adaptations from virtual reality obstacle avoidance to the physical world.
Locomotor training based in virtual reality (VR) is promising for motor skill learning, with transfer of VR skills in turn required to benefit daily life locomotion. This study aimed to assess whether VR-adapted obstacle avoidance can be transferred to a physical obstacle and whether such transfer is retained after 1 week. Thirty-two young adults were randomly divided between two groups. A control group (CG) merely walked on a treadmill and an intervention group (IG) trained crossing 50 suddenly-appearing virtual obstacles. Both groups crossed three physical obstacles (transfer task) immediately after training (T1) and 1 week later (T2, transfer retention). Repeated practice in VR led to a decrease in toe clearance along with greater ankle plantarflexion and knee extension. IG participants crossed physical obstacles with a lower toe clearance compared to CG but revealed significantly higher values compared to the VR condition. VR adaptation was fully retained over 1 week. For physical obstacle avoidance there were differences between toe clearance of the third obstacle at T1 and the first obstacle at T2, indicating only partial transfer retention. We suggest that perception-action coupling, and thus sensorimotor coordination, may differ between VR and the physical world, potentially limiting retained transfer between conditions. [Abstract copyright: © 2022. The Author(s).
The trace of the heat kernel on a compact hyperbolic 3-orbifold
The heat coefficients related to the Laplace-Beltrami operator defined on the
hyperbolic compact manifold H^3/\Ga are evaluated in the case in which the
discrete group \Ga contains elliptic and hyperbolic elements. It is shown
that while hyperbolic elements give only exponentially vanishing corrections to
the trace of the heat kernel, elliptic elements modify all coefficients of the
asymptotic expansion, but the Weyl term, which remains unchanged. Some physical
consequences are briefly discussed in the examples.Comment: 11 page
The Medical Research Council (UK)/Uganda Virus Research Institute Uganda Research Unit on AIDS--'25 years of research through partnerships'.
For the past 25Â years, the Medical Research Council/Uganda Virus Research Institute Uganda Research Unit on AIDS has conducted research on HIV-1, coinfections and, more recently, on non-communicable diseases. Working with various partners, the research findings of the Unit have contributed to the understanding and control of the HIV epidemic both in Uganda and globally, and informed the future development of biomedical HIV interventions, health policy and practice. In this report, as we celebrate our silver jubilee, we describe some of these achievements and the Unit's multidisciplinary approach to research. We also discuss the future direction of the Unit; an exemplar of a partnership that has been largely funded from the north but led in the south
Honey bee foraging distance depends on month and forage type
To investigate the distances at which honey bee foragers collect nectar and pollen, we analysed 5,484 decoded waggle dances made to natural forage sites to determine monthly foraging distance for each forage type. Firstly, we found significantly fewer overall dances made for pollen (16.8 %) than for non-pollen, presumably nectar (83.2 %; P < 2.2 × 10−23). When we analysed distance against month and forage type, there was a significant interaction between the two factors, which demonstrates that in some months, one forage type is collected at farther distances, but this would reverse in other months. Overall, these data suggest that distance, as a proxy for forage availability, is not significantly and consistently driven by need for one type of forage over the other
Vanishing Viscosity Limits and Boundary Layers for Circularly Symmetric 2D Flows
We continue the work of Lopes Filho, Mazzucato and Nussenzveig Lopes [LMN],
on the vanishing viscosity limit of circularly symmetric viscous flow in a disk
with rotating boundary, shown there to converge to the inviscid limit in
-norm as long as the prescribed angular velocity of the
boundary has bounded total variation. Here we establish convergence in stronger
and -Sobolev spaces, allow for more singular angular velocities
, and address the issue of analyzing the behavior of the boundary
layer. This includes an analysis of concentration of vorticity in the vanishing
viscosity limit. We also consider such flows on an annulus, whose two boundary
components rotate independently.
[LMN] Lopes Filho, M. C., Mazzucato, A. L. and Nussenzveig Lopes, H. J.,
Vanishing viscosity limit for incompressible flow inside a rotating circle,
preprint 2006
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