Kinase-independent function of RIP1, critical for mature T-cell survival and proliferation.

The death receptor, Fas, triggers apoptotic death and is essential for maintaining homeostasis in the peripheral lymphoid organs. RIP1 was originally cloned when searching for Fas-binding proteins and was later shown to associate also with the signaling complex of TNFR1. Although Fas exclusively induces apoptosis, TNFR1 primarily activates the pro-survival/pro-inflammatory NF-κB pathway. Mutations in Fas lead to lymphoproliferative (lpr) diseases, and deletion of TNFR1 results in defective innate immune responses. However, the function of RIP1 in the adult lymphoid system has not been well understood, primarily owing to perinatal lethality in mice lacking the entire RIP1 protein in germ cells. This current study investigated the requirement for RIP1 in the T lineage using viable RIP1 mutant mice containing a conditional and kinase-dead RIP1 allele. Disabling the kinase activity of RIP1 had no obvious impact on the T-cell compartment. However, T-cell-specific deletion of RIP1 led to a severe T-lymphopenic condition, owing to a dramatically reduced mature T-cell pool in the periphery. Interestingly, the immature T-cell compartment in the thymus appeared intact. Further analysis showed that mature RIP1(-/-) T cells were severely defective in antigen receptor-induced proliferative responses. Moreover, the RIP1(-/-) T cells displayed greatly increased death and contained elevated caspase activities, an indication of apoptosis. In total, these results revealed a novel, kinase-independent function of RIP1, which is essential for not only promoting TCR-induced proliferative responses but also in blocking apoptosis in mature T cells

Probing Solar Convection

In the solar convection zone acoustic waves are scattered by turbulent sound speed fluctuations. In this paper the scattering of waves by convective cells is treated using Rytov's technique. Particular care is taken to include diffraction effects which are important especially for high-degree modes that are confined to the surface layers of the Sun. The scattering leads to damping of the waves and causes a phase shift. Damping manifests itself in the width of the spectral peak of p-mode eigenfrequencies. The contribution of scattering to the line widths is estimated and the sensitivity of the results on the assumed spectrum of the turbulence is studied. Finally the theoretical predictions are compared with recently measured line widths of high-degree modes.Comment: 26 pages, 7 figures, accepted by MNRA

Emergency escape system uses self-braking mechanism on fixed cable

Slide-wire system with a twist level slide device incorporates automatic descent and braking for the safe and rapid evacuation of personnel from tall structures. This device is used on any tall structure that might require emergency evacuation. It is also used to transfer materials and equipment

Quantum Stochastic Processes and the Modelling of Quantum Noise

This brief article gives an overview of quantum mechanics as a {\em quantum probability theory}. It begins with a review of the basic operator-algebraic elements that connect probability theory with quantum probability theory. Then quantum stochastic processes is formulated as a generalization of stochastic processes within the framework of quantum probability theory. Quantum Markov models from quantum optics are used to explicitly illustrate the underlying abstract concepts and their connections to the quantum regression theorem from quantum optics.Comment: 14 pages, invited article for the second edition of Springer's Encyclopedia of Systems and Control (to appear). Comments welcom

Contemplations on Dirac's equation in quaternionic coordinates

A formulation of Dirac's equation using complex-quaternionic coordinates appears to yield an enormous gain in formal elegance, as there is no longer any need to invoke Dirac matrices. This formulation, however, entails several peculiarities, which we investigate and attempt to interpret

Determining solar abundances using helioseismology

The recent downward revision of solar photospheric abundances of Oxygen and other heavy elements has resulted in serious discrepancies between solar models and solar structure as determined through helioseismology. In this work we investigate the possibility of determining the solar heavy-element abundance without reference to spectroscopy by using helioseismic data. Using the dimensionless sound-speed derivative in the solar convection zone, we find that the heavy element abundance, Z, of 0.0172 +/- 0.002, which is closer to the older, higher value of the abundances.Comment: To appear in Ap

Thermonuclear Burning on the Accreting X-Ray Pulsar GRO J1744-28

We investigate the thermal stability of nuclear burning on the accreting X-ray pulsar GRO J1744-28. The neutron star's dipolar magnetic field is <3\times 10^{11} G if persistent spin-up implies that the magnetospheric radius is less than the co-rotation radius. After inferring the properties of the neutron star, we study the thermal stability of hydrogen/helium burning and show that thermonuclear instabilities are unlikely causes of the hourly bursts seen at very high accretion rates. We then discuss how the stability of the thermonuclear burning depends on both the global accretion rate and the neutron star's magnetic field strength. We emphasize that the appearance of the instability (i.e., whether it looks like a Type I X-ray burst or a flare lasting a few minutes) will yield crucial information on the neutron star's surface magnetic field and the role of magnetic fields in convection. We suggest that a thermal instability in the accretion disk is the origin of the long (~300 days) outburst and that the recurrence time of these outbursts is >50 years. We also discuss the nature of the binary and point out that a velocity measurement of the stellar companion (most likely a Roche-lobe filling giant with m_K>17) will constrain the neutron star mass.Comment: 19 pages, 3 PostScript figures, uses aaspp4.sty and epsfig.sty, to appear in the Astrophysical Journa

Probing the internal magnetic field of slowly pulsating B-stars through g modes

We suggest that high-order g modes can be used as a probe of the internal magnetic field of SPB (slowly pulsating B) stars. The idea is based on earlier work by the authors which analytically investigated the effect of a vertical magnetic field on p and g modes in a plane-parallel isothermal stratified atmosphere. It was found that even a weak field can significantly shift the g-mode frequencies -- the effect increases with mode order. In the present study we adopt the classical perturbative approach to estimate the internal field of a 4 solar mass SPB star by looking at its effect on a low-degree ($l=1$) and high-order ($n=20$) g mode with a period of about 1.5 d. We find that a polar field strength of about 110 kG on the edge of the convective core is required to produce a frequency shift of 1%. Frequency splittings of that order have been observed in several SPB variables, in some cases clearly too small to be ascribed to rotation. We suggest that they may be due to a poloidal field with a strength of order 100 kG, buried in the deep interior of the star.Comment: 4 pages, 2 figures (to appear in Astronomy & Astrophysics