Gerodontology - Status and New Challenges

Changing demographics, which include a dramatic increase in the number of old and very old individuals have great implications for the health care professions. Further, the rates of edentulousness and tooth loss are rapidly declining. Consequently, the number of teeth at risk of developing unfavorable oral diseases is growing. As patients live longer with significant chronic systemic disease, and as more older people seek dental care, practitioners will increasingly encounter medically and functionally compromised individuals. Many recent studies have shown that systemic diseases, their treatments, and functional impairments have an impact on oral health and function and consequently on the quality of life of an older person. However, the interplay between general health and oral health is a two-way relationship. Oral infections, in particular periodontal disease, give rise to pathogens, which can become blood born or aspirated into the lungs, and which may cause serious, even life-threatening consequences. An understanding of the interplay between general and oral health is imperative, if oral health care is to have a reasonable chance of success. One of the major challenges facing the dental profession today is maintaining oral health and function into the oldestold years, especially in those elderly, who do not age successfully. Age alone, however, should have no influence on the decision to treat or not to treat

Goal-Oriented Scheduling in Sensor Networks With Application Timing Awareness

— Taking inspiration from linguistics, the communications theoretical community has recently shown a significant recent interest in pragmatic, or goal-oriented, communication. In this paper, we tackle the problem of pragmatic communication with multiple clients with different, and potentially conflicting, objectives. We capture the goal-oriented aspect through the metric of Value of Information (VoI), which considers the estimation of the remote process as well as the timing constraints. However, the most common definition of VoI is simply the Mean Square Error (MSE) of the whole system state, regardless of the relevance for a specific client. Our work aims to overcome this limitation by including different summary statistics, i.e., value functions of the state, for separate clients, and a diversified query process on the client side, expressed through the fact that different applications may request different functions of the process state at different times. A query-aware Deep Reinforcement Learning (DRL) solution based on statically defined VoI can outperform naive approaches by 15-20%

Capsaicin-sensitive cutaneous primary afferents convey electrically induced itch in humans

Specially designed transcutaneous electrical stimulation paradigms can be used to provoke experimental itch. However, it is unclear which primary afferent fibers are activated and whether they represent pathophysiologically relevant, C-fiber mediated itch. Since low-threshold mechano-receptors have recently been implicated in pruriception we aimed to characterize the peripheral primary afferent subpopulation conveying electrically evoked itch in humans (50 Hz stimulation, 100 μs square pulses, stimulus-response function to graded stimulus intensity). In 10 healthy male volunteers a placebo-controlled, 24-h 8% topical capsaicin-induced defunctionalization of capsaicin-sensitive (transient receptor potential V1-positive, ‘TRPV1’+) cutaneous fibers was performed. Histaminergic itch (1% solution introduced by a prick test lancet) was provoked as a positive control condition. Capsaicin pretreatment induced profound loss of warmth and heat pain sensitivity (pain threshold and supra-threshold ratings) as assessed by quantitative sensory testing, indicative of efficient TRPV1-fiber defunctionalization (all outcomes: P 0.0001). The topical capsaicin robustly, and with similar efficaciousness, inhibited itch intensity evoked by electrical stimulation and histamine (−89 ± 4.1% and −78 ± 4.9%, respectively, both: P 0.0001 compared to the placebo patch area). The predominant primary afferent substrate for electrically evoked itch in humans, using the presently applied stimulation paradigm, is concluded to be capsaicin-sensitive polymodal C-fibers.FSW - Self-regulation models for health behavior and psychopathology - ou

Разработка инструментов продвижения инновационного продукта на рынке B2B

Тема данной работы - "Разработка инструментов продвижения инновационного продукта на рынке B2B" - в рамках которой были разработаны инструменты продвижения которые будут использоваться компанией ОАО "Манотомь". Задача данной работы заключается в анализе продукции выпускаемой компанией и инструментов продвижения используемых компанией. С целью модернизации и разработкой новых инструментов продвижения. Исходя из поставленных задач, в дипломной работе последовательно рассмотрены ряд вопросов, такие как конкурентоспособность продукции ОАО "Манотомь" а так же используемые инструменты продвижения. Разработан новый инструмент продвижения такой как контекстная реклама. Разработаны предложения по модернизации сайта. И рассчитаны оптимальные экономические затраты на внедрения данных инструментов.The topic of this work is "Development of tools for promoting an innovative product in the B2B market" - within the framework of which the promotion tools were developed that will be used by the company "Manotom". The task of this work is to analyze the products produced by the company and the promotion tools used by the company. In order to modernize and develop new promotion tools. Based on the tasks set, the thesis consistently considers a number of issues, such as the competitiveness of the products of JSC "Manotom" as well as the promotion tools used. A new promotion tool, such as contextual advertising, has been developed. Proposals for the modernization of the site have been developed. And the optimal economic costs for the implementation of these tools are calculated

Scattering Theory of Photon-Assisted Electron Transport

The scattering matrix approach to phase-coherent transport is generalized to nonlinear ac-transport. In photon-assisted electron transport it is often only the dc-component of the current that is of experimental interest. But ac-currents at all frequencies exist independently of whether they are measured or not. We present a theory of photon-assisted electron transport which is charge and current conserving for all Fourier components of the current. We find that the photo-current can be considered as an up- and down-conversion of the harmonic potentials associated with the displacement currents. As an example explicit calculations are presented for a resonant double barrier coupled to two reservoirs and capacitively coupled to a gate. Two experimental situations are considered: in the first case the ac-field is applied via a gate, and in the second case one of the contact potentials is modulated. For the first case we show that the relative weight of the conduction sidebands varies with the screening properties of the system. In contrast to the non-interacting case the relative weights are not determined by Bessel functions. Moreover, interactions can give rise to an asymmetry between absorption and emission peaks. In the contact driven case, the theory predicts a zero-bias current proportional to the asymmetry of the double barrier. This is in contrast to the discussion of Tien and Gordon which, in violation of basic symmetry principles, predicts a zero-bias current also for a symmetric double barrier.Comment: 15 pages, 6 figures, REVTE

Field-induced electronic phase separation in a cuprate high temperature superconductor

We present a combined neutron diffraction (ND) and high-field muon spin rotation ($\mu$SR) study of the magnetic and superconducting phases of the high-temperature superconductor La$_{1.94}$Sr$_{0.06}$CuO$_{4+y}$ ($T_{c} = 38$~K). We observe a linear dependence of the ND signal from the modulated antiferromagnetic order (m-AFM) on the applied field. The magnetic volume fraction measured with $\mu$SR increases linearly from 0\% to $\sim$40\% with applied magnetic field up to 8~T. This allows us to conclude, in contrast to earlier field-dependent neutron diffraction studies, that the long-range m-AFM regions are induced by an applied field, and that their ordered magnetic moment remains constant