Technological Diversification and Strategic Alliances

This contribution examines empirically the relationship between the internal technological profile and the diversification through strategic alliances of the largest 219 industrial firms world-wide. It explores three related issues. First, the paper shows that firms? internal technological diversification is more pronounced than external technological diversification. Second, it confirms the idea that technological diversification is more pronounced than product and market diversification. Finally, by means of multiple correlation analysis, this work studies the relationship between firms? economic performance, internal technological diversification and diversification through strategic alliances. The empirical investigation combines firm level data on US patents, strategic technological alliances, production and marketing alliances, and firms' economic performances

Technological diversification and strategic alliances

This contribution examines empirically the relationship between the internal technological profile and the diversification through strategic alliances of the largest 219 industrial firms world-wide. It explores three related issues. First, the paper shows that firms? internal technological diversification is more pronounced than external technological diversification. Second, it confirms the idea that technological diversification is more pronounced than product and market diversification. Finally, by means of multiple correlation analysis, this work studies the relationship between firms? economic performance, internal technological diversification and diversification through strategic alliances. The empirical investigation combines firm level data on US patents, strategic technological alliances, production and marketing alliances, and firms' economic performances

Hemostasis Proteins in Invasive Meningococcal and Nonmeningococcal Infections: A Prospective Multicenter Study

Objectives: We aimed to describe the variation of hemostasis proteins in children with bacterial infections due to different pathogens ( Neisseria meningitidis, Streptococcus pneumoniae, Staphylococcus aureus , and group A streptococcus [GAS]) and to study hemostasis proteins in relation to mortality. Design: Preplanned analysis in prospective cohort study. Setting: Hospitals in five European countries (Austria, The Netherlands, Spain, Switzerland, and the United Kingdom). Patients: Admitted children (2012-2016) with community-acquired infections due to meningococci ( n = 83), pneumococci ( n = 64), S. aureus (n = 50), and GAS ( n = 44) with available serum samples collected less than 48 hours after admission. Interventions: None. Measurements and main results: Fibronectin, plasminogen activator inhibitor type 1 (PAI-1), thrombomodulin, and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS-13) were measured in serum in 2019-2020. Additionally, von Willebrand factor, protein C, protein S, and factor IX were measured in citrate plasma available from a subset of patients. Outcome measures included in-hospital mortality and disease severity (need for ventilation/inotropes, Pediatric Index of Mortality score).Of 241 children, 21 (8.7%) died and 177 (73.5%) were admitted to PICU. Mortality rate was similar for the pathogen groups. Levels of fibronectin and thrombomodulin differed for the different pathogens ( p < 0.05). Fibronectin levels were lower in GAS infections than in S. pneumoniae and S. aureus infections but did not differ from meningococcal infections. Thrombomodulin levels in meningococcal infections were higher than in S. aureus and pneumococcal infections. Overall, the area under the curve for mortality was 0.81 (95% CI, 0.70-0.92) for thrombomodulin and 0.78 (95% CI, 0.69-0.88) for ADAMTS-13. The association of each hemostasis protein did not vary across pathogens for any of the outcome measures. Conclusions: Hemostatic disturbances in childhood bacterial infections are not limited to meningococcal sepsis but occur with a comparable severity across nonmeningococcal infections. High thrombomodulin and high ADAMTS-13 had good discriminative ability for mortality. Our results emphasize the importance of hemostatic disturbances in meningococcal and nonmeningococcal pediatric bacterial infections

Dispersibility and Storage Stability Optimization of High Dose Isoniazid Dry Powder Inhalation Formulations with L-Leucine or Trileucine

Tuberculosis is the leading cause of death from a single infectious pathogen worldwide. Lately, the targeted delivery of antibiotics to the lungs via inhalation has received increasing interest. In a previous article, we reported on the development of a spray-dried dry powder isoniazid formulation containing an L-leucine coating. It dispersed well but had poor physical stability. In this study, we aimed to improve the stability by improving the leucine coating. To this end, we optimized the spray-drying conditions, the excipient content, and the excipient itself. Using L-leucine, the tested excipient contents (up to 5%) did not result in a stable powder. Contrary to L-leucine, the stability attained with trileucine was satisfactory. Even when exposed to 75% relative humidity, the formulation was stable for at least three months. The optimal formulation contained 3% trileucine w/w. This formulation resulted in a maximum fine particle dose of 58.00 ± 2.56 mg when a nominal dose of 80 mg was dispersed from the Cyclops® dry powder inhaler. The improved moisture protection and dispersibility obtained with trileucine are explained by its amorphous nature and a higher surface enrichment during drying. Dispersion efficiency of the device decreases at higher nominal doses

The nascent ecology of social enterprise

Funder: Edmond de Rothschild FoundationsFunder: Isaac Newton Trust; doi: http://dx.doi.org/10.13039/501100004815Employing population ecology theory, we examine social enterprise population emergence in the United Kingdom after 2005 when a new organizational form for social enterprise was established. Our density dependence analysis of nearly seven thousand Community Interest Companies finds that survival is positively influenced by age and population densities of both other social enterprises and commercial organizations. Two specific patterns in population emergence are identified: social enterprise survival is more likely influenced by industry than age, a finding that we label the liability of specificity, and their survival benefits from the population density of commercial organizations but not nonprofit organizations, a finding that we label the hybrid-commercial benefit. Our research identifies the liability of specificity as a new concept in population ecology theory and the hybrid-commercial benefit as a contextual influence on social enterprise survival

The Influence of Coalition Formation on Idea Selection in Dispersed Teams: A Game Theoretic Approach

Sie, R. L. L., Bitter-Rijpkema, M., & Sloep, P. B. (2009). The Influence of Coalition Formation on Idea Selection in Dispersed Teams: A Game Theoretic Approach. In U. Cress, V. Dimitrova & M. Specht (Eds.), Learning in the Synergy of Multiple Disciplines. Proceedings of the Fourth European Conference on Technology-Enhanced Learning (EC-TEL 2009) (pp. 732-737). September, 29 - October, 2, 2009, Nice, France. Lecture Notes in Computer Science Vol. 5794. Berlin: Springer-Verlag.In an open innovation environment, organizational learning takes place by means of dispersed teams which expand their knowledge through collaborative idea generation. Research is often focused on finding ways to extend the set of ideas, while the main problem in our opinion is not the number of ideas that is generated, but a non-optimal set of ideas accepted during idea selection. When selecting ideas, coalitions form and their composition may influence the resulting set of accepted ideas. We expect that computing coalitional strength during idea selection will help in forming the right teams to have a grand coalition, or having a better allocation of accepted ideas, or neutralising factors that adversely influence the decision making process. Based on a literature survey, this paper proposes the application of the Shapley value and the nucleolus to compute coalitional strength in order to enhance the group decision making process during collaborative idea selection. This document does not represent the opinion of the European Union, and the European Union is not responsible for any use that might be made of its content.The idSpace project is partially supported/co-funded by the European Union under the Information and Communication Technologies (ICT) theme of the 7th Framework Programme for R&

Preferences of vulnerable social groups for ecosystem-based adaptation to flood risk in Central Vietnam

Developing countries are increasingly impacted by floods, especially in Asia. Traditional flood risk management, using structural measures such as levees, can have negative impacts on the livelihoods of social groups that are more vulnerable. Ecosystem-based adaptation (EbA) provides a complementary approach that is potentially more inclusive of groups that are commonly described as more vulnerable, such as the poor and women. However, there is a lack of disaggregated and quantitative information on the potential of EbA to support vulnerable groups of society. This paper provides a quantitative analysis of the differences in vulnerability to flooding as well as preferences for EbA benefits across income groups and gender. We use data collected through a survey of households in urban and rural Central Vietnam which included a discrete choice experiment on preferences for ecosystem services. A total of 1,010 households was surveyed during 2017 through a random sampling approach. Preferences are measured in monetary and non-monetary terms to avoid issues that may arise from financial constraints faced by respondents and especially the more vulnerable groups. Our results reveal that lower income households and women are overall more vulnerable than their counterparts and have stronger preferences for the majority of the EbA benefits, including flood protection, seafood abundance, tourism, and recreation suitability. These findings strongly indicate that EbA is indeed a promising tool to support groups of society that are especially vulnerable to floods. These results provide crucial insights for future implementation of EbA projects and for the integration of EbA with goals targeted at complying with the Sendai Framework and Sustainable Development Goals

Vrije-Elektronen-Laser werk aan de Universiteit van Twente in samenwerking met het Nederlands Centrum voor Laser Research

In de vakgroep Quantum Elektronica van de Faculteit Technische Natuurkunde aan de Universiteit Twente zijn momenteel drie Vrije-Elektronen-Laser projecten operationeel. De projecten worden uitgevoerd in nauwe samenwerking met het Nederlands Centrum voor Laser Research. Het FEL-onderzoek binnen de vakgroep richt zich met name op de fysische aspecten van het FEL-mechanisme en de technologische ontwikkeling van componenten voor een effectieve produktie van straling. Ook wordt veel aandacht besteed aan de ontwikkeling van diagnostiek, zowel voor de elektronenbundel als voor de optische bundel. Veel componenten zijn in huis ontwikkeld en gebouwd. Op deze wijze wordt getracht FEL’s aantrekkelijk te maken voor industriële toepassingen. Dit laatste aspect krijgt met name veel aandacht in de samenwerking met het NCLR. Hieronder volgt een korte beschrijving van de verschillende projecten