Thermic effect of glucose and amino acids in man studied by direct and indirect calorimetry

1. In order to reinvestigate the classical concept of specific dynamic action of food, the thermic effect of ingested glucose (50 g) or essential amino acids (50 g) or both was measured in seven healthy male subjects dressed in shorts, by using both direct and indirect calorimetry simultaneously. Experiments were performed under conditions of thermal comfort at 28°. 2. Energy ‘balance' (heat production minus heat losses) was negative during the control period (mean heat deficit: −16.0 ± 0.8 kJ/m2 per h. 3. Metabolic rate increased 13.6 ± 1.8% after the glucose load, 17.2 ± 1.4% after amino acids, and 17.3 ± 2.9% after both glucose and amino acids: thus there was no additive thermic effect when both nutrients were given together. 4. In contrast to the metabolic rate, heat losses were not significantly altered after nutrient ingestion; consequently, the energy ‘balance' became rapidly positive. 5. These results show that: (a) the food-induced thermogenesis, for a moderate energy intake, is less dependent on the nature of the nutrients than was classically admitted; (b) this increased heat production mainly induces changes in heat storage rather than in heat losses during the first hours following ingestion of a mea

Magnetic quantum critical point and superconductivity in UPt3 doped with Pd

Transverse-field muon spin relaxation measurements have been carried out on the heavy-fermion superconductor UPt3 doped with small amounts of Pd. We find that the critical Pd concentration for the emergence of the large-moment antiferromagnetic phase is ~0.6 at.%Pd. At the same Pd content, superconductivity is completely suppressed. The existence of a magnetic quantum critical point in the phase diagram, which coincides with the critical point for superconductivity, provides evidence for ferromagnetic spin-fluctuation mediated odd-parity superconductivity, which competes with antiferromagnetic order.Comment: 4 pages (includes 3 figures); postscript fil

Magnetic quantum critical point and superconductivity in UPt3 doped with Pd

Transverse-field muon spin relaxation measurements have been carried out on the heavy-fermion superconductor UPt3 doped with small amounts of Pd. We find that the critical Pd concentration for the emergence of the large-moment antiferromagnetic phase is ~0.6 at.%Pd. At the same Pd content, superconductivity is completely suppressed. The existence of a magnetic quantum critical point in the phase diagram, which coincides with the critical point for superconductivity, provides evidence for ferromagnetic spin-fluctuation mediated odd-parity superconductivity, which competes with antiferromagnetic order.Comment: 4 pages (includes 3 figures); postscript fil

Muon localization site in U(Pt,Pd)3

The angular and temperature (10-250 K) variation of the Knight shift of single-crystalline U(Pt0.95Pd0.05)3 has been measured in transverse field (B=0.6 T) mSR experiments. By analysing the temperature variation of the Knight shift with a modified Curie-Weiss expression the muon localization site in this hexagonal material is determined at (0,0,0).Comment: 12 pages (including 4 figures); postscript file; Proc. 8th Int. Conf. on Muon Spin Rotation, Relaxation and Resonance (Aug.30-Sept.3, Les Diablerets); 2nd version with minor correction

Evidence for a two component magnetic response in UPt3

The magnetic response of the heavy fermion superconductor UPt_3 has been investigated on a microscopic scale by muon Knight shift studies. Two distinct and isotropic Knight shifts have been found for the field in the basal plane. While the volume fractions associated with the two Knight shifts are approximately equal at low and high temperatures, they show a dramatic and opposite temperature dependence around T_N. Our results are independent on the precise muon localization site. We conclude that UPt_3 is characterized by a two component magnetic response.Comment: 5 pages, 4 figure

International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol

Epilepsy is one of the most common chronic neurological diseases in veterinary practice. Magnetic resonance imaging (MRI) is regarded as an important diagnostic test to reach the diagnosis of idiopathic epilepsy. However, given that the diagnosis requires the exclusion of other differentials for seizures, the parameters for MRI examination should allow the detection of subtle lesions which may not be obvious with existing techniques. In addition, there are several differentials for idiopathic epilepsy in humans, for example some focal cortical dysplasias, which may only apparent with special sequences, imaging planes and/or particular techniques used in performing the MRI scan. As a result, there is a need to standardize MRI examination in veterinary patients with techniques that reliably diagnose subtle lesions, identify post-seizure changes, and which will allow for future identification of underlying causes of seizures not yet apparent in the veterinary literature. There is a need for a standardized veterinary epilepsy-specific MRI protocol which will facilitate more detailed examination of areas susceptible to generating and perpetuating seizures, is cost efficient, simple to perform and can be adapted for both low and high field scanners. Standardisation of imaging will improve clinical communication and uniformity of case definition between research studies. A 6–7 sequence epilepsy-specific MRI protocol for veterinary patients is proposed and further advanced MR and functional imaging is reviewed