Sistem Pakar Untuk Pertolongan Pertama Pada Penyakit Umum Menggunakan Metode Forward Chaining

Application of expert systems are now widely used by many people, as well as application development is quite fast and good. So easy to use and many of the benefits with this application. With this application, common people can learn the science of an expert to be applied into daily life.In this study expert system is applied to diagnose the disease as first aid before consulting a doctor. In making this application, programmers consult the experts (doctors) to create a knowledge-based.Based on the questionnaire results obtained that the expert system application program as a first aid for common ailments can run well and well-presented in user interface

Sistem Pakar Untuk Penyakit Anak Menggunakan Metode Forward Chaining

The main study in this thesis is the design and the development of an expert system with forward chaining and backward chainingmethod. In this thesis, uses the children common disease due tothe body immune in young children is not as good and perfect as adult\u27s. This makes children to be infected easily.The method used in the development of this expert system isforward chaining and backward chaining, which is driven by the facts that exist. The facts obtained from the patient\u27s physical condition, or so-called symptoms. In making this expert system knowledge is required excavation by an expert engineer from the expert of the subject, in this case is a doctor. The process of extracting knowledge by means of interviews.Based on the analysis, this expert system has a percentage of program eligibility to be used by common people is at 85.4%. Moreover about the ease of USAge this program also get a high percentage

Genetic evolution of uveal melanoma guides the development of an inflammatory microenvironment

Experimental cancer immunology and therap

Norovirus outbreak in a natural playground: A One Health approach

Norovirus constitutes the most frequently identified infectious cause of disease outbreaks associated with untreated recreational water. When investigating outbreaks related to surface water, a One Health approach is insightful. Historically, there has been a focus on potential contamination of recreational water by bird droppings and a recent publication demonstrating human noroviruses in bird faeces suggested this should be investigated in future water-related norovirus outbreaks. Here, we describe a One Health approach investigating a norovirus outbreak in a natural playground. On social media, a large amount of waterfowl were reported to defecate near these playground premises leading to speculations about their potential involvement. Surface water, as well as human and bird faecal specimens, was tested for human noroviruses. Norovirus was found to be the most likely cause of the outbreak but there was no evidence for transmission via waterfowl. Cases had become known on social media prior to notification to the public health service underscoring the potential of online media as an early warning system. In view of known risk factors, advice was given for future outbreak investigations and natural playgroun

Expression of the SST receptor 2 in uveal melanoma is not a prognostic marker

Introduction: Uveal melanoma (UM) cells and neurohormone-producing cells both originate from the neural crest. Somatostatin receptors subtype 2 (SSTR2) are over-expressed in several tumors, often from neuroendocrine origin, and synthetic antagonists like octreotide and octreotate are being used as diagnostic or therapeutic agents. We investigated the SSTR2 expression in UM, and determined whether this expression was related to prognosis of the disease. Materials and methods: UM cell lines and fresh primary UM samples were tested for SSTR2 expression by autoradiography (AR) using 125I-Tyr3-octreotate. Furthermore, UM cell lines were analyzed for SSTR2 mRNA expression with quantitative real-time RT-PCR. Results: Using AR, cell-surface SSTR2 expression was demonstrated in two UM metastatic cell lines, but no expression was detected in three cell lines derived from primary UM. However, all primary and metastatic UM cell lines showed mRNA expression levels for SSTR2 using quantitative real-time RT-PCR. Only three of 14 primary UM demonstrated moderate SSTR2 expression, and this expression was not significantly associated with tumor-free survival or any tested prognostic factor. Conclusions: Based on the rare and low expression of SSTR2 found in primary UM specimens and in UM cell lines, we conclude that SSTR2 is not widely expressed in UM. Furthermore, SSTR2 expression was not associated with tumor-free survival and prognostic factors. Therefore SSTR2 is not suited as prognostic marker or therapeutic target in UM