Experimental cancer immunology and therap

Gregorius P. M. Luyten

Gülçin Gezgin

Martine J. Jager

Mehmet Dogrusöz

Pieter A. van der Velden

Robert M. Verdijk

Sjoerd H. van der Burg

T. Huibertus van Essen

Thorbald van Hall

Vonn Walter

Wilhelmina G. M. Kroes

Gezgin, G

Dogrusoz, M

van Essen, TH

Kroes, WGM

Luyten, GPM

Van der Velden, PA

Walter, V

Verdijk, Rob

van Hall, T

van der Burg, SH

Jager, MJ

EUR Research Repository

Undetermined

Genetic evolution of uveal melanoma guides the development of an inflammatory microenvironment

Uveal melanoma (UM) is characterized by a number of genetic aberrations that follow a certain chronology and are tightly linked to tumor recurrence and survival. Loss of chromosome 3, bi-allelic loss of BAP1 expression, and gain in chromosome 8q have been associated with metastasis formation and death, while loss of chromosome 3 has been associated with the influx of macrophages and T cells. We used a set of genetically-classified UM to study immune infiltration in the context of their genetic evolution. We show in two independent cohorts that lack of BAP1 expression is associated with an increased density of CD3+ T cells and CD8+ T cells. The presence of extra copies of chromosome 8q in disomy 3 tumors with a normal BAP1 expression is associated with an increased influx of macrophages (but not T cells). Therefore, we propose that the genetic evolution of UM is associated with changes in the inflammatory phenotype. Early changes resulting in gain of chromosome 8q may activate macrophage infiltration, while sequential loss of BAP1 expression seems to drive T cell infiltration in UM

Gezgin, G. (Gülçin)

Dogrusöz, M. (Mehmet)

van Essen, T.H. (T. Huibertus)

Kroes, W.G. (W.)

Luyten, G.P.M. (Gré)

Velden, P.A. (Pieter) van der

Walter, V. (Vonn)

Verdijk, R.M. (Robert)

van Hall, T. (Thorbald)

Burg, S.H. (Sjoerd) van der

Jager, M.J. (Martine J.)

Erasmus University Digital Repository

English

NARCIS 

Gezgin, G.

Dogrusoz, M.

Essen, T.H. van

Kroes, W.G.M.

Luyten, G.P.M.

Velden, P.A. van der

Walter, V.

Verdijk, R.M.

Hall, T. van

Burg, S.H. van der

Jager, M.J.

Leiden University Scholary Publications

Springer - Publisher Connector

Crossref

Cancer Immunology Immunotherapy

https://repub.eur.nl/pub/99134/art-3A10.1007-2Fs00262-017-1991-1.pdf

Genetic evolution of uveal melanoma guides the development of an inflammatory microenvironment

Abstract

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EUR Research Repository

Erasmus University Digital Repository

EUR Research Repository

NARCIS

Leiden University Scholary Publications

Springer - Publisher Connector

Crossref

EUR Research Repository

Springer - Publisher Connector

NARCIS