A Stepwise Planned Approach to the Solution of Hilbert's Sixth Problem. III : Measurements and von Neumann Projection/Collapse Rule

Supmech, the universal mechanics developed in the previous two papers, accommodates both quantum and classical mechanics as subdisciplines (a brief outline is included for completeness); this feature facilitates, in a supmech based treatment of quantum measurements, an unambiguous treatment of the apparatus as a quantum system approximated well by a classical one. Taking explicitly into consideration the fact that observations on the apparatus are made when it has `settled down after the measurement interaction' and are restricted to macroscopically distinguishable pointer readings, the unwanted superpositions of (system + apparatus) states are shown to be suppressed; this provides a genuinely physics based justification for the (traditionally \emph{postulated}) von Neumann projection/collapse rule. The decoherence mechanism brought into play by the stated observational constraints is free from the objections against the traditional decoherence program.Comment: 29 pages; one section and two references added; results unchange

Bulk and contact-sensitized photocarrier generation in single layer TPD devices

In this paper, we report on the photoelectronic properties of TPD studied in sandwich geometry. In particular, we have obtained from both forward and reverse bias measurements the "mew-tau" product for holes in TPD. "mew" is the hole mobility and "tau" the carrier trapping time. The "mew-tau" product is a measure of the electronic quality of the material and allows a quantitative comparison of different samples. We have carried out numerical simulations to understand the photocurrent in these structures. We show that in reverse bias, the photocurrent (PC) is due to bulk. The carrier generation is governed by field assisted exciton dissociation at electric fields greater than 10^6 V/cm. At lower fields the generation of carriers occurs spontaneously in the bulk of the sample. In forward bias, the photocurrent is due to exciton dissociation at the ITO contact. We also obtain a "mew-tau" product for holes from forward bias PC measurements which is in agreement with the value obtained from reverse bias measurements. Based on our experiments, we demonstrate that TPD in a sandwich structure is a good candidate for cheap large area solar blind UV detector arrays.Comment: Submitted to J. Appl. Phy

NMR analysis of the dynamic exchange of the NS2B cofactor between open and closed conformations of the West Nile Virus NS2B-NS3 protease

BACKGROUND The two-component NS2B-NS3 proteases of West Nile and dengue viruses are essential for viral replication and established targets for drug development. In all crystal structures of the proteases to date, the NS2B cofactor is located far from the substrate binding site (open conformation) in the absence of inhibitor and lining the substrate binding site (closed conformation) in the presence of an inhibitor. METHODS In this work, nuclear magnetic resonance (NMR) spectroscopy of isotope and spin-labeled samples of the West Nile virus protease was used to investigate the occurrence of equilibria between open and closed conformations in solution. FINDINGS In solution, the closed form of the West Nile virus protease is the predominant conformation irrespective of the presence or absence of inhibitors. Nonetheless, dissociation of the C-terminal part of the NS2B cofactor from the NS3 protease (open conformation) occurs in both the presence and the absence of inhibitors. Low-molecular-weight inhibitors can shift the conformational exchange equilibria so that over 90% of the West Nile virus protease molecules assume the closed conformation. The West Nile virus protease differs from the dengue virus protease, where the open conformation is the predominant form in the absence of inhibitors. CONCLUSION Partial dissociation of NS2B from NS3 has implications for the way in which the NS3 protease can be positioned with respect to the host cell membrane when NS2B is membrane associated via N- and C-terminal segments present in the polyprotein. In the case of the West Nile virus protease, discovery of low-molecular-weight inhibitors that act by breaking the association of the NS2B cofactor with the NS3 protease is impeded by the natural affinity of the cofactor to the NS3 protease. The same strategy can be more successful in the case of the dengue virus NS2B-NS3 protease.The project was funded by the Australian Research Council (http://www.arc.gov.au), grant DP0877540

Cantilever-based Resonant Gas Sensors with Integrated Recesses for Localized Sensing Layer Deposition

This work presents mass-sensitive hammerhead resonators with integrated recesses as a gas-phase chemical microsensor platform. Recesses are etched into the head region of the resonator to locally deposit chemically sensitive polymers by ink-jet printing. This permits the sensing films to be confined to areas that (a) are most effective in detecting mass loading and (b) are not strained during the in-plane vibrations of the resonator. As a result of the second point, even 5-μm thick polymer coatings on resonators with a 9-12 μm silicon thickness barely affect the Q-factor in air. This translates into higher frequency stability and ultimately higher sensor resolution compared to uniformly coated devices

Professional boundaries: crossing a line or entering the shadows?

This article explores the professional boundaries guidance for social workers. It presents research findings from the formal literature, from agency codes of practice, from telephone interviews with regulatory and professional bodies and from an exercise using ‘snowballing techniques’ in which informants responded to brief scenarios illustrating boundary dilemmas. The findings suggest that formal research plays little part in the guidance that individuals use to help them determine professional boundaries. Similarly, only 10–15 per cent of informants made regular reference to regulatory and professional codes of practice, with an even smaller percentage quoting specific sections from these codes. A slightly larger group (15–20 per cent) made fairly regular reference to their agency's policy documents. However, a clear majority relied on their own sense of what is appropriate or inappropriate, and made their judgements with no reference to any formal guidance. Agency guidance tended to ignore the ambiguous areas of practice and seemed to act as an insurance policy, brought out and dusted off when something goes awry. The authors caution against ever-increasing bullet points of advice and prescription, and advance a notion of ethical engagement in which professionals exercise their ethical senses through regular discussion of professional boundary dilemmas

Does stroke location predict walk speed response to gait rehabilitation?

Objectives Recovery of independent ambulation after stroke is a major goal. However, which rehabilitation regimen best benefits each individual is unknown and decisions are currently made on a subjective basis. Predictors of response to specific therapies would guide the type of therapy most appropriate for each patient. Although lesion topography is a strong predictor of upper limb response, walking involves more distributed functions. Earlier studies that assessed the cortico-spinal tract (CST) were negative, suggesting other structures may be important. Experimental Design: The relationship between lesion topography and response of walking speed to standard rehabilitation was assessed in 50 adult-onset patients using both volumetric measurement of CST lesion load and voxel-based lesion–symptom mapping (VLSM) to assess non-CST structures. Two functional mobility scales, the functional ambulation category (FAC) and the modified rivermead mobility index (MRMI) were also administered. Performance measures were obtained both at entry into the study (3–42 days post-stroke) and at the end of a 6-week course of therapy. Baseline score, age, time since stroke onset and white matter hyperintensities score were included as nuisance covariates in regression models. Principal Observations: CST damage independently predicted response to therapy for FAC and MRMI, but not for walk speed. However, using VLSM the latter was predicted by damage to the putamen, insula, external capsule and neighbouring white matter. Conclusions Walk speed response to rehabilitation was affected by damage involving the putamen and neighbouring structures but not the CST, while the latter had modest but significant impact on everyday functions of general mobility and gait

Rotational Effects of Twisted Light on Atoms Beyond the Paraxial Approximation

The transition probability for the emission of a Bessel photon by an atomic system is calculated within first order perturbation theory. We derive a closed expression for the electromagnetic potentials beyond the paraxial approximation that permits a systematic multipole approximation . The matrix elements between center of mass and internal states are evaluated for some specially relevant cases. This permits to clarify the feasibility of observing the rotational effects of twisted light on atoms predicted by the calculations. It is shown that the probability that the internal state of an atom acquires orbital angular momentum from light is, in general, maximum for an atom located at the axis of a Bessel mode. For a Gaussian packet, the relevant parameter is the ratio of the spread of the atomic center of mass wave packet to the transversal wavelength of the photon.Comment: 10 pages, no figure

Effects of voice on emotional arousal

Music is a powerful medium capable of eliciting a broad range of emotions. Although the relationship between language and music is well documented, relatively little is known about the effects of lyrics and the voice on the emotional processing of music and on listeners' preferences. In the present study, we investigated the effects of vocals in music on participants' perceived valence and arousal in songs. Participants (N = 50) made valence and arousal ratings for familiar songs that were presented with and without the voice. We observed robust effects of vocal content on perceived arousal. Furthermore, we found that the effect of the voice on enhancing arousal ratings is independent of familiarity of the song and differs across genders and age: females were more influenced by vocals than males; furthermore these gender effects were enhanced among older adults. Results highlight the effects of gender and aging in emotion perception and are discussed in terms of the social roles of music

Proton recoil polarization in exclusive (e,e'pp) reactions

The general formalism of nucleon recoil polarization in the (${\vec e},e'{\vec N}N$) reaction is given. Numerical predictions are presented for the components of the outgoing proton polarization and of the polarization transfer coefficient in the specific case of the exclusive $^{16}$O(${\vec e},e'{\vec p}p$)$^{14}$C knockout reaction leading to discrete states in the residual nucleus. Reaction calculations are performed in a direct knockout framework where final-state interactions and one-body and two-body currents are included. The two-nucleon overlap integrals are obtained from a calculation of the two-proton spectral function of $^{16}$O where long-range and short-range correlations are consistently included. The comparison of results obtained in different kinematics confirms that resolution of different final states in the $^{16}$O(${\vec e},e'{\vec p}p$)$^{14}$C reaction may act as a filter to disentangle and separately investigate the reaction processes due to short-range correlations and two-body currents and indicates that measurements of the components of the outgoing proton polarization may offer good opportunities to study short-range correlations.Comment: 12 pages, 6 figure

P.A.M. Dirac and the Discovery of Quantum Mechanics

Dirac's contributions to the discovery of non-relativistic quantum mechanics and quantum electrodynamics, prior to his discovery of the relativistic wave equation, are described