Invariant manifolds and the response of spiral arms in barred galaxies

The unstable invariant manifolds of the short-period family of periodic orbits around the unstable Lagrangian points $L_1$ and $L_2$ of a barred galaxy define loci in the configuration space which take the form of a trailing spiral pattern. In the present paper we investigate this association in the case of the self-consistent models of Kaufmann & Contopoulos (1996) which provide an approximation of real barred-spiral galaxies. We also examine the relation of `response' models of barred-spiral galaxies with the theory of the invariant manifolds. Our main results are the following: The invariant manifolds yield the correct form of the imposed spiral pattern provided that their calculation is done with the spiral potential term turned on. We provide a theoretical model explaining the form of the invariant manifolds that supports the spiral structure. The azimuthal displacement of the Lagrangian points with respect to the bar's major axis is a crucial parameter in this modeling. When this is taken into account, the manifolds necessarily develop in a spiral-like domain of the configuration space, delimited from below by the boundary of a banana-like non-permitted domain, and from above either by rotational KAM tori or by cantori forming a stickiness zone. We construct `spiral response' models on the basis of the theory of the invariant manifolds and examine the connection of the latter to the `response' models (Patsis 2006) used to fit real barred-spiral galaxies, explaining how are the manifolds related to a number of morphological features seen in such models.Comment: 16 Page

On the embedding of spacetime in five-dimensional Weyl spaces

We revisit Weyl geometry in the context of recent higher-dimensional theories of spacetime. After introducing the Weyl theory in a modern geometrical language we present some results that represent extensions of Riemannian theorems. We consider the theory of local embeddings and submanifolds in the context of Weyl geometries and show how a Riemannian spacetime may be locally and isometrically embedded in a Weyl bulk. We discuss the problem of classical confinement and the stability of motion of particles and photons in the neighbourhood of branes for the case when the Weyl bulk has the geometry of a warped product space. We show how the confinement and stability properties of geodesics near the brane may be affected by the Weyl field. We construct a classical analogue of quantum confinement inspired in theoretical-field models by considering a Weyl scalar field which depends only on the extra coordinate.Comment: 16 pages, new title and references adde

Cellular immune responses in amniotic fluid of women with preterm labor and intraâ amniotic infection or intraâ amniotic inflammation

ProblemPreterm birth is commonly preceded by preterm labor, a syndrome that is causally linked to both intraâ amniotic infection and intraâ amniotic inflammation. However, the stereotypical cellular immune responses in these two clinical conditions are poorly understood.Method of studyAmniotic fluid samples (n = 26) were collected from women diagnosed with preterm labor and intraâ amniotic infection (amniotic fluid ILâ 6 concentrations â ¥2.6 ng/mL and culturable microorganisms, n = 10) or intraâ amniotic inflammation (amniotic fluid ILâ 6 concentrations â ¥2.6 ng/mL without culturable microorganisms, n = 16). Flow cytometry was performed to evaluate the phenotype and number of amniotic fluid leukocytes. Amniotic fluid concentrations of classical proâ inflammatory cytokines, type 1 and type 2 cytokines, and Tâ cell chemokines were determined using immunoassays.ResultsWomen with spontaneous preterm labor and intraâ amniotic infection had (a) a greater number of total leukocytes, including neutrophils and monocytes/macrophages, in amniotic fluid; (b) a higher number of total T cells and CD4+ T cells, but not CD8+ T cells or B cells, in amniotic fluid; and (c) increased amniotic fluid concentrations of ILâ 6, ILâ 1β, and ILâ 10, compared to those with intraâ amniotic inflammation. However, no differences in amniotic fluid concentrations of Tâ cell cytokines and chemokines were observed between these two clinical conditions.ConclusionThe cellular immune responses observed in women with preterm labor and intraâ amniotic infection are more severe than in those with intraâ amniotic inflammation, and neutrophils, monocytes/macrophages, and CD4+ T cells are the main immune cells responding to microorganisms that invade the amniotic cavity. These findings provide insights into the intraâ amniotic immune mechanisms underlying the human syndrome of preterm labor.The relative distribution of innate and adaptive immune cell subsets in amniotic fluid of women with preterm labor and intraâ amniotic inflammation. Flow cytometry analysis is shown as a tâ SNE plot.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151891/1/aji13171_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151891/2/aji13171.pd

Strength, jumping, and change of direction speed asymmetries are not associated with athletic performance in elite academy soccer players

The aims of the present study were twofold: 1) to measure inter-limb asymmetries from a battery of fitness tests in youth soccer players and, 2) determine the association between asymmetry and measures of athletic performance. Sixteen elite youth soccer players (14.7 ± 0.2 years) performed a single leg Abalakov test (ABK), change of direction (COD) test over 10 m (5 + 5) and 20 m (10 + 10), and an iso-inertial power test. Subjects also performed 10 m, 20 m and 30 m sprints and a bilateral countermovement jump (CMJ), which were correlated with all ABK, COD and iso-inertial asymmetry scores. A one-way repeated measures ANOVA showed significant differences between inter-limb asymmetry scores across multiple tests (p 0.05) between the different inter-limb asymmetry scores, and between asymmetry scores and athletic performance. These findings show the test-specific nature of asymmetries in youth soccer players, with the iso-inertial power test being the most sensitive in detecting asymmetry. Moreover, the results obtained suggest that inherent asymmetry in young soccer players did not negatively impact their performance

Impurity Effects in Two-Electron Coupled Quantum Dots: Entanglement Modulation

We present a detailed analysis of the electronic and optical properties of two-electron quantum dots with a two-dimensional Gaussian confinement potential. We study the effects of Coulomb impurities and the possibility of manipulate the entanglement of the electrons by controlling the confinement potential parameters. The degree of entanglement becomes highly modulated by both the location and charge screening of the impurity atom, resulting two regimes: one of low entanglement and other of high entanglement, with both of them mainly determined by the magnitude of the charge. It is shown that the magnitude of the oscillator strength of the system could provide an indication of the presence and characteristics of impurities that could largely influence the degree of entanglement of the system.Comment: Regular Article (Journal of Physics B, in press), 9 pages, 10 figure

NGC 1300 Dynamics: III. Orbital analysis

We present the orbital analysis of four response models, that succeed in reproducing morphological features of NGC 1300. Two of them assume a planar (2D) geometry with $\Omega_p$=22 and 16 \ksk respectively. The two others assume a cylindrical (thick) disc and rotate with the same pattern speeds as the 2D models. These response models reproduce most successfully main morphological features of NGC 1300 among a large number of models, as became evident in a previous study. Our main result is the discovery of three new dynamical mechanisms that can support structures in a barred-spiral grand design system. These mechanisms are presented in characteristic cases, where these dynamical phenomena take place. They refer firstly to the support of a strong bar, of ansae type, almost solely by chaotic orbits, then to the support of spirals by chaotic orbits that for a certain number of pat tern revolutions follow an n:1 (n=7,8) morphology, and finally to the support of spiral arms by a combination of orbits trapped around L$_{4,5}$ and sticky chaotic orbits with the same Jacobi constant. We have encountered these dynamical phenomena in a large fraction of the cases we studied as we varied the parameters of our general models, without forcing in some way their appearance. This suggests that they could be responsible for the observed morphologies of many barred-spiral galaxies. Comparing our response models among themselves we find that the NGC 130 0 morphology is best described by a thick disc model for the bar region and a 2D disc model for the spirals, with both components rotating with the same pattern speed $\Omega_p$=16 \ksk !. In such a case, the whole structure is included inside the corotation of the system. The bar is supported mainly by regular orbits, while the spirals are supported by chaotic orbits.Comment: 18 pages, 32 figures, accepted for publication in MNRA

An Immunomodulatory Gallotanin-Rich Fraction From Caesalpinia spinosa Enhances the Therapeutic Effect of Anti-PD-L1 in Melanoma.

PD-1/PD-L1 pathway plays a role in inhibiting immune response. Therapeutic antibodies aimed at blocking the PD-1/PD-L1 interaction have entered clinical development and have been approved for a variety of cancers. However, the clinical benefits are reduced to a group of patients. The research in combined therapies, which allow for a greater response, is strongly encouraging. We previously characterized a polyphenol-rich extract from Caesalpinia spinosa (P2Et) with antitumor activity in both melanoma and breast carcinoma, as well as immunomodulatory activity. We hypothesize that the combined treatment with P2Et and anti-PD-L1 can improve the antitumor response through an additive antitumor effect. We investigated the antitumor and immunomodulatory activity of P2Et and anti-PD-L1 combined therapy in B16-F10 melanoma and 4T1 breast carcinoma. We analyzed tumor growth, hematologic parameters, T cell counts, cytokine expression, and T cell cytotoxicity. In the melanoma model, combined P2Et and anti-PD-L1 therapy has the following effects: decrease in tumor size; increase in the number of activated CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells; decrease in the number of suppressor myeloid cells; increase in PD-L1 expression; decrease in the frequency of CD8 <sup>+</sup> T cell expressing PD-1; improvement in the cytotoxic activity of T cells; and increase in the IFN γ secretion. In the breast cancer model, P2Et and PD-L1 alone or in combination show antitumor effect with no clear additive effect. This study shows that combined therapy of P2Et and anti-PD-L1 can improve antitumor response in a melanoma model by activating the immune response and neutralizing immunosuppressive mechanisms

Immune-system-dependent anti-tumor activity of a plant-derived polyphenol rich fraction in a melanoma mouse model.

Recent findings suggest that part of the anti-tumor effects of several chemotherapeutic agents require an intact immune system. This is in part due to the induction of immunogenic cell death. We have identified a gallotannin-rich fraction, obtained from Caesalpinia spinosa (P2Et) as an anti-tumor agent in both breast carcinoma and melanoma. Here, we report that P2Et treatment results in activation of caspase 3 and 9, mobilization of cytochrome c and externalization of annexin V in tumor cells, thus suggesting the induction of apoptosis. This was preceded by the onset of autophagy and the expression of immunogenic cell death markers. We further demonstrate that P2Et-treated tumor cells are highly immunogenic in vaccinated mice and induce immune system activation, clearly shown by the generation of interferon gamma (IFN-γ) producing tyrosine-related protein 2 antigen-specific CD8+ T cells. Moreover, the tumor protective effects of P2Et treatment were abolished in immunodeficient mice, and partially lost after CD4 and CD8 depletion, indicating that P2Et's anti-tumor activity is highly dependent on immune system and at least in part of T cells. Altogether, these results support the hypothesis that the gallotannin-rich fraction P2Et's anti-tumor effects are mediated to a great extent by the endogenous immune response following to the exposure to immunogenic dying tumor cells