Experimental and numerical studies on the shared activation anchoring of NSMR CFRP applied to RC beams

A shared activation anchoring method used for carbon fiber reinforced polymer (CFRP) near surface mounted reinforcement (NSMR) strengthening is hypothesized to provide a mean to exploit the full material capacity and to tailor desired responses. To investigate strengthening efficiency, failure control as well as ductility levels, the developed strengthening system were mounted on reinforced concrete T-beams with a length of 6400 mm. Initial activation stresses of 50% (1100 MPa) and 70% (1540 MPa) were applied to an 8 mm CFRP rod by the anchor system. Then, in some beams finite element simulations were carried out for better understanding the obtained results with regard to the overall structural behaviour. Good correlations between the FE-simulation and tested responses were observed, where a high utilization of the CFRP material (up to 3300MPa) was reached. Installation of the activated system worked well, without premature failure. Additionally it was possible to control the failure development, where intermediate crack de-bonding was achieved when testing the beams with an activation level of approximately 50%, while fibre rupture occurred at the level of 70% activation, thus providing a CFRP strain of approximately 0,02.SFRH/BSAB/150266/2019; S&P Denmark and Reinholdt W. Jorck and Hustrus foundation. FCT, respectively, financed by European Social Fund and by national funds through the FCT/MCTE

Experimental study on Shear capacity of cementitious composite RPC Beams using high strength steel

Reactive Powder Concrete (RPC) is a special concrete where the microstructure is optimized by precise gradation of all particles in the mix to yield maximum density. Therefore, Reactive Powder Concrete exhibits ultra-high strength and durability. The high strength reinforcement (HSR) has high strength and good plastic deformation properties. The combination of RPC and high strength reinforcement can fully exploit their respective advantages. At present, there is little research on shear capacity of HSR reinforced RPC concrete beams, neither are design guidelines for this type of structure. Therefore, it is imperative to make detailed investigations on the shear capacity of this type of concrete. In this paper, thirty-two full scale shear tests of high strength steel reinforced RPC beams were carried out. The parameters affecting the shear capacity of this type of structures were studied, the major failure modes of this type structure due to shear are identified

Severity of current depression and remission status are associated with structural connectome alterations in major depressive disorder

Major depressive disorder (MDD) is associated to affected brain wiring. Little is known whether these changes are stable over time and hence might represent a biological predisposition, or whether these are state markers of current disease severity and recovery after a depressive episode. Human white matter network ("connectome") analysis via network science is a suitable tool to investigate the association between affected brain connectivity and MDD. This study examines structural connectome topology in 464 MDD patients (mean age: 36.6 years) and 432 healthy controls (35.6 years). MDD patients were stratified categorially by current disease status (acute vs. partial remission vs. full remission) based on DSM-IV criteria. Current symptom severity was assessed continuously via the Hamilton Depression Rating Scale (HAMD). Connectome matrices were created via a combination of T1-weighted magnetic resonance imaging (MRI) and tractography methods based on diffusion-weighted imaging. Global tract-based metrics were not found to show significant differences between disease status groups, suggesting conserved global brain connectivity in MDD. In contrast, reduced global fractional anisotropy (FA) was observed specifically in acute depressed patients compared to fully remitted patients and healthy controls. Within the MDD patients, FA in a subnetwork including frontal, temporal, insular, and parietal nodes was negatively associated with HAMD, an effect remaining when correcting for lifetime disease severity. Therefore, our findings provide new evidence of MDD to be associated with structural, yet dynamic, state-dependent connectome alterations, which covary with current disease severity and remission status after a depressive episode

Critical Grain Size of Fine Aggregates in the View of the Rheology of Mortar

The aim of this research was to investigate the validity of the Krieger-Dougherty model as a quantitative model to predict the viscosity of mortar depending on various aggregate sizes. The Krieger-Dougherty model reportedly predicted the viscosity of a suspension, which includes cement-based materials. Concrete or mortar incorporates natural resources, such as sand and gravel, referred to as aggregates, which can make up as much as 80% of the mixture by volume. Cement paste is a suspending medium at fresh state and then becomes a binder to link the aggregate after its hydration. Both the viscosity of the suspending medium and the characteristics of the aggregates, therefore, control the viscosity of the cement-based materials. In this research, various sizes and gradations of fine aggregate samples were prepared. Workability and rheological properties were measured using fresh-state mortar samples and incorporating the various-sized fine aggregates. Yield stress and viscosity measurements were obtained by using a rheometer. Based on the packing density of each fine aggregate sample, the viscosity of the mortar was predicted with the Krieger-Dougherty model. In addition, further adjustments were made to determine the water absorption of fine aggregates and was transferred from successful experiment to simulation for more accurate prediction. It was also determined that both yield stress and viscosity increase when the fine aggregate mean size decreases throughout the mix. However, when the mean size of the fine aggregates is bigger than 0.7 mm, the yield stress is not affected by the size of the fine aggregate. Additionally, if aggregate grains get smaller up to 0.3 mm, their water absorption is critical to the rheological behavior

Genetic variants associated with longitudinal changes in brain structure across the lifespan

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging

Genetic variants associated with longitudinal changes in brain structure across the lifespan

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging

Beyond the Global Brain Differences:Intraindividual Variability Differences in 1q21.1 Distal and 15q11.2 BP1-BP2 Deletion Carriers

BACKGROUND: Carriers of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants exhibit regional and globalbrain differences compared with noncarriers. However, interpreting regional differences is challenging if a globaldifference drives the regional brain differences. Intraindividual variability measures can be used to test for regionaldifferences beyond global differences in brain structure.METHODS: Magnetic resonance imaging data were used to obtain regional brain values for 1q21.1 distal deletion (n =30) and duplication (n = 27) and 15q11.2 BP1-BP2 deletion (n = 170) and duplication (n = 243) carriers and matchednoncarriers (n = 2350). Regional intra-deviation scores, i.e., the standardized difference between an individual’sregional difference and global difference, were used to test for regional differences that diverge from the globaldifference.RESULTS: For the 1q21.1 distal deletion carriers, cortical surface area for regions in the medial visual cortex, posterior cingulate, and temporal pole differed less and regions in the prefrontal and superior temporal cortex differedmore than the global difference in cortical surface area. For the 15q11.2 BP1-BP2 deletion carriers, cortical thicknessin regions in the medial visual cortex, auditory cortex, and temporal pole differed less and the prefrontal andsomatosensory cortex differed more than the global difference in cortical thickness.CONCLUSIONS: We find evidence for regional effects beyond differences in global brain measures in 1q21.1 distaland 15q11.2 BP1-BP2 copy number variants. The results provide new insight into brain profiling of the 1q21.1 distaland 15q11.2 BP1-BP2 copy number variants, with the potential to increase understanding of the mechanismsinvolved in altered neurodevelopment