2D-BN nanoparticles as a spectroscopic marker and drug delivery system with protection properties

An application of 2D-BN nanoparticles as a spectroscopic marker, weak luminescent marker and anticancer drug (doxorubicin, DOX) delivery system with protection properties was studied for the LNCaP strains of cancer cells using FTIR and Raman spectroscopy for analysing the cancer cells, cells with BN, the cancer cells with DOX, and the cancer cells with BN nanoparticles loaded by DOX. Study of IR absorption and Raman spectra of the LNCaP strains of cancer cells incubated with 2D-BN nanoparticles for 1 hour showed that the 2D-BN nanoparticles could pass through the cell membrane and localize inside the membrane or close to the membrane in the cytoplasm of the cells. We registered the spectra of the disturbed lipids during the DOX-2D-BN passing through the membrane. After incubation for 2 hours and more, spectral changes in other structural components of the cell (nuclei, cytoplasm, mitochondria) can be registered. Confocal microscopy showed that a gold nanostructured support enhances the fluorescence of the cancer cells with 2D-BN as well as that with DOX, however the double action of 2D-BN and DOX on the cancer cells aggravates the emission property of the studied system. An MTT test showed that the toxicity of DOX on the 2D-BN nanoparticles is less than that on the reference cells, and at the same time the efficiency of the DOX action on the cancer cells does not change

Acoustic Response to the Action of Nanosecond Laser Pulses on an In/CdTe Thin-Film Heterostructure

The photothermoacoustic method has been used for diagnostics of thermobarodynamic processes in the metal In(400 nm)/semiconductor (CdTe) thin-film system under nanosecond laser irradiation (7 ns, λ = 532 nm) in natural conditions (in air) and in a liquid medium (water). From the analysis of the data obtained, the dependence of the pressure induced in the energy-release region on the irradiation energy den-sity has been established and the melting threshold of In film has been determined. Under irradiation of In/CdTe in water, the pressure is higher than in air: 17 times higher at the melting threshold of In film and 30 times higher at twice the temperature. It has been found that the laser pulse treatment of In/CdTe/Au samples in water makes it possible to obtain diode structures with better parameters: smaller leak currents and a steeper current-voltage characteristic under the forward bias of the p-n junction

Laser-induced phase separation of silicon carbide

Understanding the phase separation mechanism of solid-state binary compounds induced by laser-material interaction is a challenge because of the complexity of the compound materials and short processing times. Here we present xenon chloride excimer laser-induced melt-mediated phase separation and surface reconstruction of single-crystal silicon carbide and study this process by high-resolution transmission electron microscopy and a time-resolved reflectance method. A single-pulse laser irradiation triggers melting of the silicon carbide surface, resulting in a phase separation into a disordered carbon layer with partially graphitic domains (???2.5 nm) and polycrystalline silicon (???5 nm). Additional pulse irradiations cause sublimation of only the separated silicon element and subsequent transformation of the disordered carbon layer into multilayer graphene. The results demonstrate viability of synthesizing ultra-thin nanomaterials by the decomposition of a binary system.open

Modernization of cancer services in Moscow, the main challenges and possible solutions

Malignant neoplasms are taking second place in the structure of mortality and continue to be a major public health problem, both in the Russian Federation and in Moscow. The relevance of medical care to patients with malignant neoplasms is determined by their social significance, as well as the complexity of detection and treatment, the continuing increase in the incidence. The aim of the Department of health and Oncology service of the city is to solve this problem

STATE OF THE ART OF CANCER CARE DELIVER Y IN MOSCOW

Abstract:The globally increased concern with the situation, existing in oncology, is conditioned by a steady incidence rate of malignant neoplasms, having a tendency to its growth. Annually over 7 million people die in the world due to cancer, by 2020, according to WHO estimations, this index will increase to 10 million. By the end of the 2013 report year patient population with cancer, registered in cancer care facilities of the Russian Federation, is 3 098 855 (2 995 566 in 2012), i. e. 2,1% of the population of the country. The system of cancer care delivery to the population in the Russian Federation and in Moscow is aimed at an early diagnostics and prevention of malignant neoplasms. Municipal cancer care service establishes the patients’ routes at suspicion on oncological disease and determines the functions of all links of health care for this type of patients. Stateof-the-art delivery of oncological specialty care has been built up with account of modern demands and is functionally structured in accordance with tree-level municipal health care system

Change of Study, Training System, the Possibility of a Survey of Students XXI-st Century

As teachers we have to think about our capability of delivering both „Traditional” and „Future-oriented” content in the language of digital natives. The first requires broad sweeping material conversion and methodological change, while the second calls for additional new content and new thinking. Nowadays, when the digital competence of students far exceeds that of the average adult or even of teachers the most important task is the development of educational materials that are easy to process and work with. If we want to address our students successfully and keep pace with the times we have to rely on the latest information and communication technology and web 2.0 approaches. The forthcoming analysis of the learning styles of students and the information acquisition and teaching styles of instructors aims to increase the effectiveness of the teaching – learning process along with identifying the necessary background criteria. Additional goals include the examination of the most frequently used platforms and methods and the respective correlations both from the vantage point of instructors and students