Anthelmintic tolerance in free-living and facultative parasitic isolates of Halicephalobus (Panagrolaimidae)

Studies on anthelmintic resistance in equine parasites do not include facultative parasites. Halicephalobus gingivalis is a free-living bacteriovorous nematode and a known facultative parasite of horses with a strong indication of some form of tolerance to common anthelmintic drugs. This research presents the results of an in vitro study on the anthelmintic tolerance of several isolates of Halicephalobus to thiabendazole and ivermectin using an adaptation of the Micro-Agar Larval Development Test hereby focusing on egg hatching and larval development. Panagrellus redivivus and Panagrolaimus superbus were included as a positive control. The results generally show that the anthelmintic tolerance of Halicephalobus to both thiabendazole and ivermectin was considerably higher than that of the closely related Panagrolaimidae and, comparing to other studies, than that of obligatory equine parasites. Our results further reveal a remarkable trend of increasing tolerance from fully free-living isolates towards horse-associated isolates. In vitro anthelmintic testing with free-living and facultative parasitic nematodes offers the advantage of observing drug effect on the complete lifecycle as opposed to obligatory parasites which can only be followed until the third larval stage. We therefore propose Halicephalobus gingivalis as an experimental tool to deepen our understanding of the biology of anthelmintic tolerance

Embryonic origins of hull cells in the flatworm <i>Macrostomum lignano</i> through cell lineage analysis: developmental and phylogenetic implications

The development of macrostomid flatworms is of interest for evolutionary developmental biology research because these taxa combine characteristics of the canonical spiral cleavage pattern with significant deviations from this pattern. One such deviation is the formation of hull cells, which surround the remaining embryonic primordium during early development. Using live observations with a 4D microscope system, histology, and 3D reconstructions, we analyzed the ontogeny of these hull cells in the macrostomid model organism Macrostomum lignano. Our cell lineage analysis allowed us to find the precursors of the hull cells in this species. We discuss the relation between macrostomid development and the development of other spiralians and the question of whether hull cells are homologous within rhabditophoran flatworms

Destruction thermique des poussieres et fines de fonderie par injection au cubilot

SIGLEAvailable at INIST (FR), Document Supply Service, under shelf-number : RP 400 (1919) / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Destruction thermique des poussieres et fines de fonderie par injection au cubilot

SIGLEAvailable at INIST (FR), Document Supply Service, under shelf-number : RP 400 (1919) / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

HUBUNGAN ANTARA DUKUNGAN KELUARGA DENGAN TINGKAT STRES PADA PASIEN KANKER PAYUDARA DI POLIKLINIK BEDAH ONKOLOGI RSUP DR. KARIADI SEMARANG

Kanker payudara sering menyebabkan kematian, gejala fisik, perubahan kondisi tubuh dan menimbulkan efek samping pengobatan, maka sangat berpotensi menimbulkan stres. Keadaan stres ini sangat berpengaruh terhadap sistem kekebalan tubuh. Untuk itu, penderita kanker memerlukan dorongan dan motivasi dari keluarga untuk dapat mengatasi stres yang sedang dialami. Dukungan keluarga mempengaruhi kesehatan dan melindungi seseorang terhadap stres