Genetic Diversity of Four Filipino Negrito Populations from Luzon: Comparison of Male and Female Effective Population Sizes and Differential Integration of Immigrants into Aeta and Agta Communities

Genetic data corresponding to four negrito populations (two Aeta and two Agta; n = 120) from the Luzon region of the Philippines have been analyzed. These data comprise mitochondrial DNA (mtDNA) hypervariable segment 1 haplotypes and haplogroups, Y-chromosome haplogroups and short tandem repeats (STRs), autosomal STRs, and X-chromosome STRs. The genetic diversity and structure of the populations were investigated at a local, regional, and interregional level. We found a high level of autosomal differentiation, combined with no significant reduction in diversity, consistent with long-term settlement of the Luzon region by the ancestors of the Agta and Aeta followed by reduced gene flow between these two ethnolinguistic groups. Collectively, the Aeta have a much higher ratio of female:male effective population size than do the Agta, a finding that supports phylogenetic analysis of their mtDNA and Y-chromosome haplogroups, which suggests different genetic sex-biased contributions from putative Austronesian source populations. We propose that factors of social organization that led to the reduction in Agta female effective population size may also be linked to the limited incorporation of female lineages associated with the settlement of the Philippines by Austronesian speakers; conversely, the reduction in Aeta male effective population size, relative to females, could be indicative of a limited incorporation of male lineages associated with this demographic process

VIS: the visible imager for Euclid

Euclid-VIS is a large format visible imager for the ESA Euclid space mission in their Cosmic Vision program, scheduled for launch in 2019. Together with the near infrared imaging within the NISP instrument it forms the basis of the weak lensing measurements of Euclid. VIS will image in a single r+i+z band from 550-900 nm over a field of view of ~0.5 deg2. By combining 4 exposures with a total of 2240 sec, VIS will reach to V=24.5 (10{\sigma}) for sources with extent ~0.3 arcsec. The image sampling is 0.1 arcsec. VIS will provide deep imaging with a tightly controlled and stable point spread function (PSF) over a wide survey area of 15000 deg2 to measure the cosmic shear from nearly 1.5 billion galaxies to high levels of accuracy, from which the cosmological parameters will be measured. In addition, VIS will also provide a legacy imaging dataset with an unprecedented combination of spatial resolution, depth and area covering most of the extra-Galactic sky. Here we will present the results of the study carried out by the Euclid Consortium during the Euclid Definition phase.Comment: 10 pages, 6 figure

Correlates of Premenstrual Dysphoria in Help-seeking Women

Comparisons were made between the premenstrual changes reported by nontreatment-seekers (NTS) (n = 32) and those of treatment-seekers (TS) (n = 52). The Premenstrual Assessment Form Luteal Phase and Follicular Phase versions were completed and the Beck Depression Inventory, the Automatic Thoughts Questionnaire and the State-Trait Anxiety Inventory were completed at both the luteal and follicular phases. Prospective daily ratings were made for two treatment cycles on the Daily Ratings Form and TS were screened for a mood-disorder history. Using the commonly cited 30% decrease in dysphoric levels from the pre- to postmenstrual phases as the criterion of prospective confirmation, women with prospectively confirmed dysphoria (PMD +) were not significantly more symptomatic than those without prospective dysphoric confirmation (PMD -). However, TS were more symptomatic than NTS on measures of depression, anxiety and frequency of negative automatic thoughts but not on mood behaviour and physical changes reflected in the PAF scales. No demographic differences were found between TS and NTS. Results did not support the issue of requiring `confirmation' of self-reports within a help-seeking group or the use of the 30% criterion in particular. Findings further suggest that the 95-item PAF may be inadequate in differentiating TS from others

Short text messages to encourage adherence to medication and follow-up for people with psychosis (Mobile.Net): randomized controlled trial in Finland

Background: A text messaging service (short message service [SMS]) has the potential to target large groups of people with long-term illnesses such as serious mental disorders, who may have difficulty with treatment adherence. Robust research on the impact of mobile technology interventions for these patients remains scarce. Objective: The main objective of our study was to investigate the impact of individually tailored short text messages on the rate of psychiatric hospital readmissions, health care service use, and clinical outcomes. In addition, we analyzed treatment costs. Methods: Between September 2011 and November 2012, we randomly assigned 1139 people to a tailored text message intervention (n=569) or usual care (n=570). Participants received semiautomated text messages for up to 12 months or usual care. The primary outcome, based on routinely collected health register data, was patient readmission into a psychiatric hospital during a 12-month follow-up period. Secondary outcomes were related to other service use, coercion, medication, adverse events, satisfaction, social functioning, quality of life, and economic factors (cost analysis). Results: There was 98.24% (1119/1139) follow-up at 12 months. Tailored mobile telephone text messages did not reduce the rate of hospital admissions (242/563, 43.0% of the SMS group vs 216/556, 38.8% of the control group; relative risk 1.11; 95% CI 0.92-1.33; P=.28), time between hospitalizations (mean difference 7.0 days 95% CI –8.0 to 24.0; P=.37), time spent in a psychiatric hospital during the year (mean difference 2.0 days 95% CI –2.0 to 7.0; P=.35), or other service outcomes. People who received text messages were less disabled, based on Global Assessment Scale scores at the time of their readmission, than those who did not receive text messages (odds ratio 0.68; 95% CI 0.47-0.97; P=.04). The costs of treatment were higher for people in the SMS group than in the control group (mean €10,103 vs €9210, respectively, P<.001). Conclusions: High-grade routinely collected data can provide clear outcomes for pragmatic randomized trials. SMS messaging tailored with the input of each individual patient did not decrease the rate of psychiatric hospital visits after the 12 months of follow-up. Although there may have been other, more subtle effects, the results of these were not evident in outcomes of agreed importance to clinicians, policymakers, and patients and their families

The classification of bulimic eating disorders: a community-based cluster analysis study

Published online by Cambridge University Press 09 Jul 2009There is controversy over how best to classify eating disorders in which there is recurrent binge eating. Many patients with recurrent binge eating do not meet diagnostic criteria for either of the two established eating disorders, anorexia nervosa or bulimia nervosa. The present study was designed to derive an empirically based, and clinically meaningful, diagnostic scheme by identifying subgroups from among those with recurrent binge eating, testing the validity of these subgroups and comparing their predictive validity with that of the DSM-IV scheme. A general population sample of 250 young women with recurrent binge eating was recruited using a two-stage design. Four subgroups among the sample were identified using a Ward's cluster analysis. The first subgroup had either objective or subjective bulimic episodes and vomiting or laxative misuse; the second had objective bulimic episodes and low levels of vomiting or laxative misuse; the third had subjective bulimic episodes and low levels of vomiting or laxative misuse; and the fourth was heterogeneous in character. This cluster solution was robust to replication. It had good descriptive and predictive validity and partial construct validity. The results support the concept of bulimia nervosa and its division into purging and non-purging subtypes. They also suggest a possible new binge eating syndrome. Binge eating disorder, listed as an example of Eating Disorder Not Otherwise Specified within DSM-IV, did not emerge from the cluster analysis.P. J. Hay, C. G. Fairburn and H. A. Dol

Nomic-Role Nonreductionism: Identifying Properties by Total Nomic Roles

I introduce "nomic-role nonreductionism" as an alternative to traditional causal-role functionalism in the philosophy of mind. Rather than identify mental properties by a theory that describes their intra-level causal roles via types of inputs, internal states, and outputs, I suggest that one identify mental properties by a more comprehensive theory that also describes inter-level realization roles via types of lower-level engineering, internal mental states, and still higher-level states generated by them. I defend this position on grounds that mental properties should be understood by our best scientific theories, which at present include informatioin about mental engineering. I further defend this claim by a "parity of reasons" argument. Causal-role functionalists are justified to include sensory stimuli in their theory of mind as opposed to, say, the remote causes of sensory stimuli because the former but not the latter are items of direct mental production. But ditto for the system's physical realizations. They too directly produce mental states, only not by "causing" them but by "realizing" them. Engineering realizations and their input triggering conditions work in tandem. In addition, I tell a related but more general metaphysical story about property identity, namely, that the traditional causal theory should be replaced by a more comprehensive nomic theory that individuates properties by their intra-level causal powers as well as their inter-level realization capacities

Realization Reductios, and Category Inclusion

Thomas Polger and Laurence Shapiro argue that Carl Gillett's much publicized dimensioned theory of realization is incoherent, being subject to a reductio. Their argument turns on the fact that Gillett's definition of realization makes property instances the exclusive relata of the realization relation, while his belief in multiple realization implies its denial, namely, that properties are the relata of the realization relation on occasions of multiple realization. Others like Sydney Shoemaker have also expressed their view of realization in terms of property instances, yet they too have accepted the multiple realizability of properties. Thus I am interested in the more general issue raised by Polger and Shapiro's argument. Specifically, I show how to supplement a theory of realization with a category-inclusive auxiliary assumption, which avoids the stated reductio. I then offer a few reasons to justify the proposed category-inclusive view of realization, making some comparisons to supervenience and causation along the way

Reinforcing the Three ‘R’s: Reduction, Reception, and Replacement

Philosophers of science have offered different accounts of what it means for one scientific theory to reduce to another. I propose a more or less friendly amendment to Kenneth Schaffner’s “General Reduction-Replacement” model of scientific unification. Schaffner interprets scientific unification broadly in terms of a continuum from theory reduction to theory replacement. As such, his account leaves no place on its continuum for type irreducible and irreplaceable theories. The same is true for other accounts that incorporate Schaffner's continuum, for example, those developed by Paul Churchland, Clifford Hooker, and John Bickle. Yet I believe a more general account of scientific unification should include type irreducible and irreplaceable theories in an account of their partial reduction, specifically, when there is a reduction of their tokens. Thus I propose a “Reduction-Reception-Replacement” model wherein type irreducible and irreplaceable theories are accepted or received for the purpose of unifying domains of particulars. I also suggest a link between this kind of token reduction and mechanistic explanation

On Physical Multiple Realization

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138292/1/papq00379.pd

Geoscientists-In-The-Park Summer Internship Mapping Shoreline Change with the National Park Service

This project paper details the activities carried out as a Geologist/GIS Specialist in the Gateway National Recreation Area as a part of the Geoscientists-In-The-Park internship program. The focus of this position was on supporting the geomorphological monitoring efforts of the National Park Service. This was accomplished through a combination of field data collection, GIS analysis, report writing, and project work. By the end of the internship, substantial progress was made to the formation of Gateway’s Annual 1D and 2D report for 2015-2016, field data were collected for the 2016 summer season, changes in geomorphology were explored and summarized for the Sagamore Hill National Historic Site, and feedback was provided to refine the 3D monitoring protocol document. This paper is organized into five chapters. Chapter 1 serves as an introduction to the internship and organizations. Chapter 2 describes the organizational structure within which the internship operated. Chapter 3 gives an account of the responsibilities of the internship. Chapter 4 consists of an assessment of the internship, while Chapter 5 provides concluding remarks