278 research outputs found

    A streamtube model of rotating turbidity currents

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    A rotating turbidity current is modeled as a steady tube of sediment-laden water traversing along and down a uniform slope representing the continental shelf. The model includes parameterizations of erosion of sediment from the seabed into the plume, deposition onto the seafloor, bottom friction, and turbulent entrainment of the overlying ambient seawater. The purpose of the work is to study how these parameterizations affect the path the current takes on the slope and to determine criteria which affect the qualitative behavior of the model solutions. It is found that there are three possible final states to the model. The first is near-geostrophic flow along the slope which is similar to the uniform state found in streamtube models. The second is the catastrophic state which describes an erosive current entraining and depositing a large amount of sediment and traveling downslope much like an avalanche. In the third state the current decelerates and flows along slope whilst depositing its load. The current is extinguished on a length scale 2(aQ*/vsKfr0)1/2 from the source where a is the aspect ratio, Q* is the initial volume flux, vs is the settling velocity, Kf is a frictional coefficient and r0 is the deposition rate. The state the current adopts depends on the initial conditions and model parameters. A linear stability analysis finds that the geostrophic state is always unstable while the catastrophic state is always stable. Thus the model predicts either catastrophic flow down slope or depositional flow along-slope. Given a sufficiently large initial disturbance the current will always ignite. This behavior is illustrated with parameters appropriate to the Kveitehola outflow. However the catastrophic state is unrealistic in that the turbulent energy required to maintain the sediment in suspension can be greater than that available to the current. Consequently a five-equation model is introduced which contains a turbulent kinetic energy equation and a parameterization of interfacial shear stress based on turbulence. With this model the Coriolis force has a much greater impact on the plume\u27s path and the sediment erosion is not so unreasonably large

    Exploring the anthelmintic properties of Australian native shrubs with respect to their potential role in livestock grazing systems

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    We measured in vitro anthelmintic activity in extracts from 85 species of Australian native shrub, with a view to identifying species able to provide a degree of worm control in grazing systems. Approximately 40% of the species showed significant activity in inhibiting development of Haemonchus contortus larvae. The most active extracts showed IC50 values of 60–300 mg/ml. Pre-incubation with polyvinylpolypyrrolidine removed the activity from some extracts, implicating tannins as the bioactive agent, while in other cases the pre-incubation had no effect, indicating the presence of other anthelmintic compounds. Plant reproductive maturity (onset of flowering or fruiting) was associated with increasing anthelmintic activity in some species. Variability was observed between plants of the same species growing in different environments, while variation between individual plants of the same species within a single field suggests the existence of distinct chemotypes. Significant activity against adult H. contortus worms in vitro was also demonstrated in a limited number of extracts tested against this life stage. Our study indicates that there is potential for Australian native shrubs to play an anthelmintic role in grazing systems, and highlights some plant biology factors which will need to be considered in order to maximize any anthelmintic effects.A. C. Kotze, J. O’Grady, J. Emms, A. F. Toovey, S. Hughes, P. Jessop, M. Bennell P. E. Vercoe and D. K. Revel

    Patient journey following lumbar spinal fusion surgery (LSFS): protocol for a multicentre qualitative analysis of the patient rehabilitation experience (FuJourn)

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    INTRODUCTION: There has been a 65% increase in lumbar spinal fusion surgery (LSFS) worldwide over the last 13 years, with costs of £26 million to the UK National Health Service annually. Patient dissatisfaction with outcome and persistent pain and disability incurs further costs. Three trials provide low-quality evidence for the role of physiotherapy. Our UK surveys investigating physiotherapy/surgeon practice concluded rehabilitation should be tailored to the individual patient owing to considerable clinical heterogeneity. This study will explore the perceptions of patients who undergo LSFS to inform precision rehabilitation. METHODS AND ANALYSIS: A qualitative study, using interpretive phenomenological analysis, will recruit a purposive sample (n=40) to ensure patterns of similarity and difference in their journeys can be explored. In-depth semistructured interviews will be undertaken following discharge from hospital and at 12 months postsurgery. Patients' preoperative and postoperative experiences, underlying attitudes and beliefs towards the surgical intervention, facilitators and barriers to recovery, adherence to advice and physiotherapy, experiences of rehabilitation and return to normal function/activity/work will be explored. A 12-month patient diary will provide real time access to patient data, capturing a weekly record of life as lived, including symptoms, medication, experiences of stages of recovery, rehabilitation adherence, healthcare professional appointments, attitudes, their feelings and experiences throughout their journey. Data will be analysed in a number of stages in accordance with interpretive phenomenological analysis, supported using NVivo software. Analysis of the first interviews and patient diaries will afford a rich density of data to build an overall understanding of the patients' lived experiences, informing the 12-month interview. Strategies (eg, reflexivity) will ensure trustworthiness. ETHICS AND DISSEMINATION: The study has ethical approval (IRAS 223283). Findings will ensure that patient-driven data inform precision rehabilitation by understanding the patient journey. Findings will be disseminated through peer-reviewed journals and conferences

    Mitigation of carbon using Atriplex nummularia revegetation

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    The use of abandoned or marginally productive land to mitigate greenhouse gas emissions may avoid competition with food and water production. Atriplex nummularia Lindl. is a perennial shrub commonly established for livestock forage on saline land, however, its potential for carbon mitigation has not been systematically evaluated. Similarly, although revegetation is an allowable activity to mitigate carbon within Article 3.4 of the United Nations Framework Convention on Climate Change's Kyoto Protocol, there is a paucity of information on rates of carbon mitigation in soils and biomass through this mechanism. For six sites where A. nummularia had been established across southern Australia four were used to assess changes in soil carbon storage and four were used to develop biomass carbon sequestration estimates. A generalised allometric equation for above and below ground biomass was developed, with a simple crown volume index explaining 81% of the variation in total biomass. There were no significant differences in soil organic carbon storage to 0.3 m or 2 m depth compared to existing agricultural land-use. Between 2.2 and 8.3 Mg C ha−1 or 0.2–0.6 Mg C ha−1 yr−1 was sequestered in above and below ground biomass and this translates to potential total sequestration of 1.1–3.6 Tg C yr−1 on saline land across Australia. Carbon income and forage grazing may thus provide a means to finance the stabilization of compromised land

    Development and validation of two clinical prediction models to inform clinical decision-making for lumbar spinal fusion surgery for degenerative disorders and rehabilitation following surgery: protocol for a prospective observational study

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    INTRODUCTION: Potential predictors of poor outcome will be measured at baseline: (1) preoperatively to develop a clinical prediction model to predict which patients are likely to have favourable outcome following lumbar spinal fusion surgery (LSFS) and (2) postoperatively to predict which patients are likely to have favourable long-term outcomes (to inform rehabilitation). METHODS AND ANALYSIS: Prospective observational study with a defined episode inception of the point of surgery. Electronic data will be collected through the British Spine Registry and will include patient-reported outcome measures (eg, Fear-Avoidance Beliefs Questionnaire) and data items (eg, smoking status). Consecutive patients (≥18 years) undergoing LSFS for back and/or leg pain of degenerative cause will be recruited. EXCLUSION CRITERIA: LSFS for spinal fracture, inflammatory disease, malignancy, infection, deformity and revision surgery. 1000 participants will be recruited (n=600 prediction model development, n=400 internal validation derived model; planning 10 events per candidate prognostic factor). The outcome being predicted is an individual's absolute risk of poor outcome (disability and pain) at 6 weeks (objective 1) and 12 months postsurgery (objective 2). Disability and pain will be measured using the Oswestry Disability Index (ODI), and severity of pain in the previous week with a Numerical Rating Scale (NRS 0-10), respectively. Good outcome is defined as a change of 1.7 on the NRS for pain, and a change of 14.3 on the ODI. Both linear and logistic (to dichotomise outcome into low and high risk) multivariable regression models will be fitted and mean differences or ORs for each candidate predictive factor reported. Internal validation of the derived model will use a further set of British Spine Registry data. External validation will be geographical using two spinal registries in The Netherlands and Switzerland. ETHICS AND DISSEMINATION: Ethical approval (University of Birmingham ERN_17-0446A). Dissemination through peer-reviewed journals and conferences
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