Mechanical Stimulation of Fibroblasts by Extracorporeal Shock Waves: Modulation of Cell Activation and Proliferation Through a Transient Proinflammatory Milieu

Extracorporeal shock waves (ESWTs) are \u201cmechanical\u201d waves, widely used in regenerative medicine, including soft tissue wound repair. Although already being used in the clinical practice, the mechanism of action underlying their biological activities is still not fully understood. In the present paper we tried to elucidate whether a proinflammatory effect may contribute to the regenerative potential of shock waves treatment. For this purpose, we exposed human foreskin fibroblasts (HFF1 cells) to an ESWT treatment (100 pulses using energy flux densities of 0.19 mJ/mm2 at 3 Hz), followed by cell analyses after 5 min, up to 48 h. We then evaluated cell proliferation, reactive oxygen species generation, ATP release, and cytokine production. Cells cultured in the presence of lipopolysaccharide (LPS), to induce inflammation, were used as a positive control, indicating that LPS-mediated induction of a proinflammatory pattern in HFF1 increased their proliferation. Here, we provide evidence that ESWTs affected fibroblast proliferation through the overexpression of selected cytokines involved in the establishment of a proinflammatory program, superimposable to what was observed in LPS-treated cells. The possibility that inflammatory circuits can be modulated by ESWT mechanotransduction may disclose novel hypothesis on their biological underpinning and expand the fields of their biomedical application

Search for leptonic decays of D0 mesons

We search for the flavor-changing neutral current decays D0\to mu+mu- and D0\to e+e-, and for the lepton-flavor violating decays D0\to e\pm mu\mp using 660 fb^-1 of data collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. We find no evidence for any of these decays. We obtain significantly improved upper limits on the branching fractions: B(D0\to mu+mu-)<1.4x10-7, B(D0\to e+e-)<7.9x10-8, and B(D0\to e+mu-)+B(D0\to mu+e-)<2.6x10-7 at 90% confidence level.Comment: 6 pages, 3 figure

Evidence for direct CP violation in the decay B->D(*)K, D->KsPi+Pi- and measurement of the CKM phase phi3

We present a new measurement of the unitarity triangle angle phi3 using a Dalitz plot analysis of the KsPi+Pi- decay of the neutral D meson produced in B->D(*)K decays. The method exploits the interference between D0 and D0bar to extract the angle phi3, strong phase delta and the ratio r of suppressed and allowed amplitudes. We apply this method to a 605 fb-1 data sample collected by the Belle experiment. The analysis uses three decays: B->DK, and B->D*K with D*->DPi0 and D*->Dgamma, as well as the corresponding charge-conjugate modes. From a combined maximum likelihood fit to the three modes, we obtain phi3 = 78.4^+10.8_-11.6 +- 3.6 (syst) +- 8.9 (model) degrees. CP conservation in this process is ruled out at the confidence level (1-CL)=5x10^-4, or 3.5 standard deviations.Comment: 10 pages, 5 figures, 4 tables. Replaced by version published in Phys. Rev.

Measurement of Inclusive Radiative B-meson Decays with a Photon Energy Threshold of 1.7 GeV

Using 605/fb of data collected at the Upsilon(4S) resonance we present a measurement of the inclusive radiative B-meson decay channel, B to X_s gamma. For the lower photon energy thresholds of 1.7, 1.8, 1.9 and 2.0GeV, as defined in the rest frame of the B-meson, we measure the partial branching fraction and the mean and variance of the photon energy spectrum. At the 1.7GeV threshold we obtain the partial branching fraction BF(B to X_s gamma) = (3.45 +/- 0.15 +/- 0.40) x 10^-4, where the errors are statistical and systematic.Comment: 9 pages, 3 figures, 2 table

Observation of the ϕ(1680)\phi(1680) and the Y(2175) in e+e−→ϕπ+π−e^+ e^- \to \phi\pi^+\pi^-

The cross sections for $e^+ e^- \to \phi\pi^+\pi^-$ and e^+ e^- \to \phi \fzero are measured from threshold to $\sqrt{s}=3.0$ $\hbox{GeV}$ using initial state radiation. The analysis is based on a data sample of 673 fb$^{-1}$ collected on and below the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider. First measurements are reported for the resonance parameters of the $\phi(1680)$ in the $\phi\pi^+\pi^-$ mode: $m=(1689\pm 7\pm 10)$ MeV/$c^2$ and $\Gamma=(211\pm 14\pm 19)$ MeV/$c^2$. A structure at $\sqrt{s}=2.1 \hbox{GeV}/c^2$, corresponding to the so called Y(2175), is observed; its mass and width are determined to be $2079\pm13^{+79}_{-28}$ MeV/$c^2$ and $192\pm23^{+25}_{-61} \hbox{MeV}/c^2$, respectively.Comment: 11 pages, 6 figures. Add one plot. Accepted by Phys.Rev.D(RC

Measurements of Charmless Hadronic b->s Penguin Decays in the pi+pi-K+pi- Final State and First Observation of B0 -> rho0K+pi-

We report measurements of charmless hadronic B^0 decays into the pi+pi-K+pi+ final state. The analysis uses a sample of 657x10^6 BBbar pairs collected with the Belle detector at the KEKB asymmetric-energy e+e- collider at the Y(4S) resonance. The decay B^0 -> rho0 Kpi is observed for the first time; the significance is 5.0sigma and the corresponding partial branching fraction for M_Kpi in (0.75,1.20) GeV/c^2 is [2.8 +- 0.5(stat) +-0.5(syst)] x 10^{-6}. We also obtain the first evidence for B^0 -> f0Kpi with 3.5sigma significance and for B^0 -> pi+pi-K*0 with 4.5sigma significance. For the two-body decays B^0 -> rho0K*0 and B^0 -> f0K*0, the significances are 2.7sigma and 2.5sigma, respectively, and the upper limits on the branching fractions are 3.4x10^{-6} and 2.2x10^{-6} at 90% confidence level.Comment: 6 pages, 3 figures. accepted by PRD(RC

Search for Lepton Flavor and Lepton Number Violating tau Decays into a Lepton and Two Charged Mesons

We search for lepton flavor and lepton number violating tau decays into a lepton (ell = electron or muon) and two charged mesons (h,h' = pi^\pm or K^\pm), tau- -> ell-h+h'- and tau- -> ell+h-h'-, using 671 fb^{-1} of data collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. We obtain 90% C.L. upper limits on the branching fractions in the range (4.4-8.8)x10^{-8} for tau -> ehh', and (3.3-16)x10^{-8} for tau -> muhh' processes. These results improve upon previously published upper limits by factors between 1.6 to 8.8.Comment: 15 page, 7 figures, submitted to Phys. Lett.

Search for the X(1812) in B±→K±ωϕB^{\pm} \to K^{\pm} \omega \phi

We report on a search for the X(1812) state in the decay $B^{\pm} \to K^{\pm} \omega \phi$ with a data sample of $657\times10^6$ $B\bar{B}$ pairs collected with the Belle detector at the KEKB $e^+e^-$ collider. No significant signal is observed. An upper limit ${\cal B}(B^{\pm} \to K^{\pm} X(1812),X(1812) \to \omega \phi)<3.2\times 10^{-7}$ (90% C.L.) is determined. We also constrain the three-body decay branching fraction to be ${\cal B}(B^{\pm} \to K^{\pm} \omega \phi)$ $<$ 1.9 $\times 10^{-6}$ (90% C.L.).Comment: 5pages,2 figures(3 figure files). submitted to PRD(RC

Observation of B+ -> Dbar*0 tau+ nu_tau and Evidence for B+ -> Dbar^0 tau+ nu_tau at Belle

We present measurements of B+ -> Dbar*0 tau+ nu_tau and B+ -> Dbar^0 tau+ nu_tau decays in a data sample of 657 x 10^6 BBbar pairs collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. We find 446^{+58}_{-56} events of the decay B+ -> Dbar*0 tau+ nu_tau with a significance of 8.1 standard deviations, and 146^{+42}_{-41} events of the decay B+ -> Dbar0 tau+ nu_tau with a significance of 3.5 standard deviations. The latter signal provides the first evidence for this decay mode. The measured branching fractions are B(B+ -> Dbar*0 tau+ nu_tau)=(2.12^{+0.28}_{-0.27} (stat) +- 0.29 (syst)) % and B(B+ -> Dbar0 tau+ nu_tau)=(0.77 +- 0.22 (stat) +- 0.12 (syst)) %.Comment: 6 pages, 4 figures, submitted to Phys. Rev. Let