Multimedia courseware: Never mind the quality how much will it cost to develop?

This paper evaluates multimedia courseware costing techniques such as the US Airforce Interactive Courseware Method (Golas, 1993), CBT Analyst (Kearsley, 1985), CEAC (Schooley, 1988) and MEEM (Marshall, Samson, Dugard, & Scott, 1994) against the data from ten multimedia courseware developments. The Relative Error and Mean Absolute Relative Error (MARE) are calculated to allow comparison of the different methods

The case of Johannesburg water: What really happened at the pre-paid ‘Parish pump’

Patrick Bond and Jackie Dugard consider South Africa’s retail water policy and delivery system through the dual lens of the proceedings in Mazibuko & Others v City of Johannesburg & Others , heard in the Johannesburg High Court from 3-5 December 2007, and a recent hydropolitical analysis by the country’s leading water authority, Mike Muller. Together they raise crucial debates around the first democratic government’s success in delivering water to people on low incomes. Several policy and practical issues are highlighted as deserving special scrutiny: the constitutional implications of pre-paid water meters and shallow sanitation, especially in cases of water emergency and chronic poverty; the origins and sufficiency of Free Basic Water (FBW) as well as the unaffordability for poor households of water beyond the current FBW allocation; and the politics of local and national state-society relations in a context of transnational corporations, multilateral financial institutions and market-oriented state policies. The authors’ bias is towards unveiling power relations that maintain poor people in water poverty, notwithstanding ‘developmental’ rhetori

The use of ICT in the assessment of modern languages: the English context and European viewpoints

The ever increasing explosion of highly attractive multimedia resources on offer has boosted the use of information and communication technology (ICT) in the teaching and learning of modern languages. The use of ICT to assess languages is less frequent, however, although online testing is starting to develop. This paper examines the national context for the assessment of modern foreign language proficiency in England, outlines the kinds of assessment currently available and the development of electronic forms of assessment and compares the above with the survey results of a European Union (EU) funded project on current good practice in online assessment of languages in other European countries. The findings indicate that speaking is inadequately served by online testing as tests currently focus primarily on receptive language skills. The implications for future successful online testing include the incorporation of interactive skills and effective formative feedback

Development of a tool to predict outcome of Autologous Chondrocyte Implantation

Objective. The study had 2 objectives: first, to evaluate the success of autologous chondrocyte implantation (ACI) in terms of incidence of surgical re-intervention, including arthroplasty, and investigate predictors of successful treatment outcome. The second objective was to derive a tool predicting a patient’s arthroplasty risk following ACI. Design. In this Level II, prognostic study, 170 ACI-treated patients (110 males [aged 36.8 ± 9.4 years]; 60 females [aged 38.1 ± 10.2 years]) completed a questionnaire about further surgery on their knee treated with ACI 10.9 ± 3.5 years previously. Factors commonly assessed preoperatively (age, gender, defect location and number, previous surgery at this site, and the preoperative Lysholm score) were used as independent factors in regression analyses. Results. At final follow-up (maximum of 19 years post-ACI), 40 patients (23.5%) had undergone surgical re-intervention following ACI. Twenty-six patients (15.3%) underwent arthroplasty, more commonly females (25%) than males (10%; P = 0.001). Cox regression analyses identified 4 factors associated with re-intervention: age at ACI, multiple operations before ACI, patellar defects, and lower pretreatment Lysholm scores (Nagelkerke’s R2 = 0.20). Six predictive items associated with risk of arthroplasty following ACI (Nagelkerke’s R2 = 0.34) were used to develop the Oswestry Risk of Knee Arthroplasty index with internal crossvalidation. Conclusion. In a single-center study, we have identified 6 factors (age, gender, location and number of defects, number of previous operations, and Lysholm score before ACI) that appear to influence the likelihood of ACI patients progressing to arthroplasty. We have used this information to propose a formula or “tool” that could aid treatment decisions and improve patient selection for ACI

The relationship between group identification and satisfaction with life in a cross-cultural community sample

A variety of studies have shown that group identification (a sense of belonging to one’s social group, coupled with a sense of commonality with the group’s members) is linked to high levels of satisfaction with life (SWL). The aim of the present study was to support and extend this literature by: i) investigating the link between group identification and SWL with a large cross-cultural community sample; ii) examining whether the relationship is moderated by nationality; and iii) considering whether SWL is enhanced by possessing multiple group identifications simultaneously. Utilizing data from Wave 1 of the Health in Groups project, 3,829 participants from both Scotland and Italy completed a questionnaire assessing their identification with their family, their local community, and a group of their choice, as well as their level of SWL. Higher identification with each group predicted higher SWL. Nationality was a marginal moderator of the relationship between family identification and SWL, with the relationship being stronger for Italian participants than for Scottish participants. There was also an additive effect of group identification, with a positive relationship between the number of groups with which participants identified and their SWL. These effects were obtained even after controlling for gender, age, employment status, nationality, and extent of contact with each group. The implications for healthcare professionals and their patients are discussed

Log D_7.4 and plasma protein binding of synthetic cannabinoid receptor agonists and a comparison of experimental and predicted lipophilicity

The emergence of new synthetic cannabinoid receptor agonists (SCRAs) onto the illicit drugs market continues to cause harm, and the overall availability of physicochemical and pharmacokinetic data for new psychoactive substances is lacking. The lipophilicity of 23 SCRAs and the plasma protein binding (PPB) of 11 SCRAs was determined. Lipophilicity was determined using a validated chromatographic hydrophobicity index (CHI) log D method; tested SCRAs showed moderate to high lipophilicity, with experimental log D7.4 ranging from 2.48 (AB-FUBINACA) to 4.95 (4F-ABUTINACA). These results were also compared to in silico predictions generated using seven commercially available software packages and online tools (Canvas; ChemDraw; Gastroplus; MoKa; PreADMET; SwissADME; and XlogP). Licenced, dedicated software packages provided more accurate lipophilicity predictions than those which were free or had prediction as a secondary function; however, the latter still provided competitive estimates in most cases. PPB of tested SCRAs, as determined by equilibrium dialysis, was in the upper range of the lipophilicity scale, ranging from 90.8% (ADB-BUTINACA) to 99.9% (BZO-HEXOXIZID). The high PPB of these drugs may contribute to reduced rate of clearance and extended durations of pharmacological effects compared to lesser-bound SCRAs. The presented data improve understanding of the behaviour of these drugs in the body. Ultimately, similar data and predictions may be used in the prediction of the structure and properties of drugs yet to emerge on the illicit market