Evaluation of Adjunctive Mycophenolate for Large Vessel Giant Cell Arteritis

Funding: We are grateful to Versus Arthritis (grant 22088) and PMR/GCA Scotland for supporting our workPeer reviewedPublisher PD

Stratified glucocorticoid monotherapy is safe and effective for most cases of giant cell arteritis

Funding: We are grateful to Versus Arthritis (grant 12159) for supporting our work.Peer reviewedPublisher PD

Actions infinit\'esimales dans la correspondance de Langlands locale p-adique

Let V be a two-dimensional absolutely irreducible p-adic Galois representation and let Pi be the p-adic Banach space representation associated to V via Colmez's p-adic Langlands correspondence. We establish a link between the infinitesimal action of GL_2(Q_p) on the locally analytic vectors of Pi, the differential equation associated to V via the theory of Fontaine and Berger, and the Sen polynomial of V. This answers a question of Harris and gives a new proof of a theorem of Colmez: Pi has nonzero locally algebraic vectors if and only if V is potentially semi-stable with distinct Hodge-Tate weights.Comment: Completely revised version, to appear in Math. Annale

Structural determinants of CO2-sensitivity in the β connexin family suggested by evolutionary analysis

none8siA subclade of connexins comprising Cx26, Cx30, and Cx32 are directly sensitive to CO2. CO2 binds to a carbamylation motif present in these connexins and causes their hemichannels to open. Cx26 may contribute to CO2-dependent regulation of breathing in mammals. Here, we show that the carbamylation motif occurs in a wide range of non-mammalian vertebrates and was likely present in the ancestor of all gnathostomes. While the carbamylation motif is essential for connexin CO2-sensitivity, it is not sufficient. In Cx26 of amphibia and lungfish, an extended C-terminal tail prevents CO2-evoked hemichannel opening despite the presence of the motif. Although Cx32 has a long C-terminal tail, Cx32 hemichannels open to CO2 because the tail is conformationally restricted by the presence of proline residues. The loss of the Cterminal tail of Cx26 in amniotes was an evolutionary innovation that created a connexin hemichannel with CO2-sensing properties suitable for the regulation of breathing.noneDospinescu V.-M.; Nijjar S.; Spanos F.; Cook J.; de Wolf E.; Biscotti M.A.; Gerdol M.; Dale N.Dospinescu, V. -M.; Nijjar, S.; Spanos, F.; Cook, J.; de Wolf, E.; Biscotti, M. A.; Gerdol, M.; Dale, N