Basu N

Chan K

Cheung SM

Dospinescu P

Erwig L

Gray S

He J

Hutcheon G

Keenan K

Schrepf A

Senn N

Waiter G

\ua9 2019, American College of RheumatologyObjective: To investigate the potential structural and metabolic role of skeletal muscle in systemic lupus erythematosus (SLE)–related fatigue. Methods: A case–control, multimodal magnetic resonance imaging (MRI) study was conducted. Cases were patients with inactive SLE who reported chronic fatigue. Controls were age- and sex-matched healthy members of the general population. Patients were clinically characterized and then underwent a 3T whole-body MRI scan. Resting and dynamic 31P MRI spectroscopy of the calf muscles was applied, from which phosphocreatine (PCr) recovery halftime, a marker of mitochondrial dysfunction, was computed. In addition, microstructural sequences (T1-weighted anatomic images, T2 mapping, and diffusion tensor imaging) were acquired. Descriptive statistics evaluated group differences and within-case physical fatigue correlations were explored. Results: Of the 37 recruits (mean age 43.8 years, 89.2% female), cases (n = 19) reported higher levels of physical fatigue, pain, depression, and sleep disturbance compared to the control group (P &lt; 0.0001). PCr was greater (P = 0.045) among cases (mean \ub1 SD 33.0 \ub1 9.0 seconds) compared to controls (mean \ub1 SD 27.1 \ub1 6.6 seconds). No microstructural group differences were observed. Within cases, physical fatigue did not correlate with PCr (r = –0.28, P = 0.25). Conclusion: We report preliminary data demonstrating greater skeletal muscle mitochondrial dysfunction among fatigued patients with SLE compared to healthy controls

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Metabolic and Structural Skeletal Muscle Health in Systemic Lupus Erythematosus–Related Fatigue: A Multimodal Magnetic Resonance Imaging Study

Metabolic and Structural Skeletal Muscle Health in Systemic Lupus Erythematosus–Related Fatigue: A Multimodal Magnetic Resonance Imaging Study

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