901 research outputs found
Gauge invariance of parametrized systems and path integral quantization
Gauge invariance of systems whose Hamilton-Jacobi equation is separable is
improved by adding surface terms to the action fuctional. The general form of
these terms is given for some complete solutions of the Hamilton-Jacobi
equation. The procedure is applied to the relativistic particle and toy
universes, which are quantized by imposing canonical gauge conditions in the
path integral; in the case of empty models, we first quantize the parametrized
system called ``ideal clock'', and then we examine the possibility of obtaining
the amplitude for the minisuperspaces by matching them with the ideal clock.
The relation existing between the geometrical properties of the constraint
surface and the variables identifying the quantum states in the path integral
is discussed.Comment: 23 page
Olive leaf extract inhibits metastatic melanoma spread through suppression of epithelial to mesenchymal transition
Olive tree leaves are an abundant source of bioactive compounds with several beneficial effects for human health, including a protective role against many types of cancer. In this study, we investigated the effect of an extract, obtained from olive tree (Olea europaea L.) leaves (OLE), on proliferation, invasion, and epithelial to mesenchymal transition (EMT) on metastatic melanoma, the highly aggressive form of skin cancer and the deadliest diseases. Our results demonstrated that OLE inhibited melanoma cells proliferation through cell cycle arrest and induction of apoptotic cell death. Moreover, OLE suppressed the migration, invasion, and colonies formation of human melanoma cells. Similar to our in vitro findings, we demonstrated that the oral administration of OLE inhibited cutaneous tumor growth and lung metastasis formation in vivo by modulating the expression of EMT related factors. In addition, the anti-proliferative and anti-invasive effects of OLE against melanoma were also related to a simultaneous targeting of mitogen-activated protein kinase and PI3K pathways, both in vitro and in vivo. In conclusion, our findings suggest that OLE has the potential to inhibit the metastatic spread of melanoma cells thanks to its multifaceted mechanistic effects, and may represent a new add-on therapy for the management of metastatic melanoma
Role of surgical setting and patients-related factors in predicting the occurrence of postoperative pulmonary complications after abdominal surgery
OBJECTIVE: The aim of this retrospective study was to evaluate the role of surgical setting (urgent vs. elective) and approach (open vs. laparoscopic) in affecting postoperative pulmonary complications (PPCs) prevalence in patients undergoing abdominal surgery.
PATIENTS AND METHODS: After local Ethical Committee approval, 409 patients who had undergone abdominal surgery between January and December 2014 were included in the final analysis. PPCs were defined as the development of one of the following new findings: respiratory failure, pulmonary infection, aspiration pneumonia, pleural effusion, pneumothorax, atelectasis on chest X-ray, bronchospasm or un-planned urgent re-intubation.
RESULTS: PPCs prevalence was greater in urgent (33%) vs. elective setting (7%) (chi(2) with Yates correction: 44; p=0.0001) and in open (6%) vs. laparoscopic approach (1.9%) (chi(2) with Yates correction: 12; p=0.0006). PPCs occurrence was positively correlated with in-hospital mortality (Biserial Correlation r=0.37; p=0.0001). Logistic regression showed that urgent setting (p=0.000), Ariscat (Assess Respiratory Risk in Surgical Patients in Catalonia) score (p=0.004), and age (p=0.01) were predictors of PPCs. A cutoff of 23 for Ariscat score was also identified as determining factor for PPCs occurrence with 94% sensitivity and 29% specificity.
CONCLUSIONS: Patients undergoing abdominal surgery in an urgent setting were exposed to a higher risk of PPCs compared to patients scheduled for elective procedures. Ariscat score fitted with PPCs prevalence and older patients were exposed to a higher risk of PPCs. Prospective studies are needed to confirm these result
C IV BAL disappearance in a large SDSS QSO sample
Broad absorption lines (BALs) in the spectra of quasi-stellar objects (QSOs)
originate from outflowing winds along our line of sight; winds are thought to
originate from the inner regions of the QSO accretion disk, close to the
central supermassive black hole (SMBH). Winds likely play a role in galaxy
evolution and aid the accretion mechanism onto the SMBH. BAL equivalent widths
can change on typical timescales from months to years; such variability is
generally attributed to changes in the covering factor and/or in the ionization
level of the gas. We investigate BAL variability, focusing on BAL
disappearance. We analyze multi-epoch spectra of more than 1500 QSOs -the
largest sample ever used for such a study- observed by different programs from
the Sloan Digital Sky Survey-I/II/III (SDSS), and search for disappearing C IV
BALs. The spectra rest-frame time baseline ranges from 0.28 to 4.9 yr; the
source redshifts range from 1.68 to 4.27. We detect 73 disappearing BALs in the
spectra of 67 sources. This corresponds to 3.9% of disappearing BALs, and 5.1%
of our BAL QSOs exhibit at least one disappearing BAL. We estimate the average
lifetime of a BAL along our line of sight (~ 80-100 yr), which appears
consistent with the accretion disk orbital time at distances where winds are
thought to originate. We inspect properties of the disappearing BALs and
compare them to the properties of our main sample. We also investigate the
existence of a correlation in the variability of multiple troughs in the same
spectrum, and find it persistent at large velocity offsets between BAL pairs,
suggesting that a mechanism extending on a global scale is necessary to explain
the phenomenon. We select a more reliable sample of disappearing BALs following
Filiz Ak et al. (2012), where a subset of our sample was analyzed, and compare
the findings from the two works, obtaining generally consistent results.Comment: 22 pages, 9 figures. Accepted for publication in A&
Management training for hospital administrators: sentinel lymph-node biopsy under local anaesthetic for carcinoma of the breast–organizational and economic impact
This study compares sentinel lymph-node biopsy carried out at the time of removal of the primary breast tumour, under general anaesthetic, with sentinel lymph-node biopsy carried out under local anaesthetic prior to the main operation. It compares the total cost of the two treatment approaches, in terms of average income and of their impact on the subsequent programming of operations and hence on waiting lists and income
Deep infiltrating endometriosis of the colon causing cyclic bleeding
[Description] Endometriosis, the presence of functional endometrial tissue outside the uterus, occurs in about 3–10% of women of reproductive age and is a cause of chronic pelvic pain and infertility for some.1 Bowel involvement may be present in about 5–10% of these women, mostly affecting the rectum and distal sigmoid (over 80% of cases), and, more infrequently, the appendix, ileum and caecum. The most common lesions involve only the serosa (endometriotic implants) but they can penetrate the muscular layers of the wall, in which case they are called deep infiltrating endometriosis. (...)(undefined
The path from trigeminal asymmetry to cognitive impairment: a behavioral and molecular study
Trigeminal input exerts acute and chronic effects on the brain, modulating cognitive functions. Here, new data from humans and animals suggest that these effects are caused by trigeminal influences on the Locus Coeruleus (LC). In humans subjects clenching with masseter asymmetric activity, occlusal correction improved cognition, alongside with reductions in pupil size and anisocoria, proxies of LC activity and asymmetry, respectively. Notably, reductions in pupil size at rest on the hypertonic side predicted cognitive improvements. In adult rats, a distal unilateral section of the trigeminal mandibular branch reduced, on the contralateral side, the expression of c-Fos (brainstem) and BDNF (brainstem, hippocampus, frontal cortex). This counterintuitive finding can be explained by the following model: teeth contact perception loss on the lesioned side results in an increased occlusal effort, which enhances afferent inputs from muscle spindles and posterior periodontal receptors, spared by the distal lesion. Such effort leads to a reduced engagement of the intact side, with a corresponding reduction in the afferent inputs to the LC and in c-Fos and BDNF gene expression. In conclusion, acute effects of malocclusion on performance seem mediated by the LC, which could also contribute to the chronic trophic dysfunction induced by loss of trigeminal input
Cosmological perturbations in FRW model with scalar field within Hamilton-Jacobi formalism and symplectic projector method
The Hamilton-Jacobi analysis is applied to the dynamics of the scalar
fluctuations about the Friedmann-Robertson-Walker (FRW). The gauge conditions
are found from the consistency conditions. The physical degrees of freedom of
the model are obtain by symplectic projector method. The role of the linearly
dependent Hamiltonians and the gauge variables in Hamilton-Jacobi formalism is
discussed.Comment: 11 page
Global phase time and path integral for the Kantowski--Sachs anisotropic univers
The action functional of the anisotropic Kantowski--Sachs cosmological model
is turned into that of an ordinary gauge system. Then a global phase time is
identified for the model by imposing canonical gauge conditions, and the
quantum transition amplitude is obtained by means of the usual path integral
procedure of Fadeev and Popov.Comment: 11 page
Integrated Nitrogen CAtchment model (INCA) applied to a tropical catchment in the Atlantic Forest, São Paulo, Brazil
International audienceStream-water flows and in-stream nitrate and ammonium concentrations in a small (36.7 ha) Atlantic Forest catchment were simulated using the Integrated Nitrogen in CAtchments (INCA) model version 1.9.4. The catchment, at Cunha, is in the Serra do Mar State Park, SE Brazil and is nearly pristine because the nearest major conurbations, São Paulo and Rio, are some 450 km distant. However, intensive farming may increase nitrogen (N) deposition and there are growing pressures for urbanisation. The mean-monthly discharges and NO3-N concentration dynamics were simulated adequately for the calibration and validation periods with (simulated) loss rates of 6.55 kg.ha?1 yr?1 for NO3-N and 3.85 kg.ha?1 yr?1 for NH4-N. To investigate the effects of elevated levels of N deposition in the future, various scenarios for atmospheric deposition were simulated; the highest value corresponded to that in a highly polluted area of Atlantic Forest in Sao Paulo City. It was found that doubling the atmospheric deposition generated a 25% increase in the N leaching rate, while at levels approaching the highly polluted São Paulo deposition rate, five times higher than the current rate, leaching increased by 240%, which would create highly eutrophic conditions, detrimental to downstream water quality. The results indicate that the INCA model can be useful for estimating N concentration and fluxes for different atmospheric deposition rates and hydrological conditions
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