11/09/1989 - Craig Chesner

Rapporto dell'Undicesima Campagna di Scavo della Missione Archeologica del Centro di Studi Papirologici a Soknopaiou Nesos (Fayyum, Egitto)

01/24/2012 - Former Charleston Resident Honored Through Music.pdf

La Campagna di Scavo 2011 ha riguardato il necessario restauro di strutture del tempio di Soknopaios, devastato da scavatori clandestini, che, approfittando del disordine politico e sociale seguìto alla rivoluzione in Egitto, hanno compiuto diverse incursioni sul sito

Genome-wide association study identifies markers associated with carcass and meat quality traits in Italian Large White pigs

A GWAS was performed using the genotypes obtained by PorcineSNP60 v2 BeadChip and 11 phenotypic traits (carcass lean meat percentage; backfat thickness; Longissimus thoracis muscle thickness; lightness; backfat thickness measured with caliper at the midline; meat pH measured at about 1 h post mortem and 24 h post mortem; CIE L*, a* and b* color parameters; and water-holding capacity). Three markers were associated with three of the phenotypic traits considered: M1GA0009592 (SSC7) with backfat thickness and lean meat content, DIAS0002910 (SSC6) and ALGA0109856 (SSC6) with water-holding capacity. The marker M1GA0009592, associated with backfat thickness, lies in a QTL region near the gene JARID2, which is a transcription factor also involved in the regulation of adipose-derived stem cell pluripotency. The results seem to indicate a possible role of these genomic regions in the regulation of pig carcass fatness (i.e. backfat at last rib) and water-holding capacity

An Approximate Maximum Likelihood Method for the Joint Estimation of Range and Doppler of Multiple Targets in OFDM-Based Radar Systems

In this manuscript, an innovative method for the detection and the estimation of multiple targets in a radar system employing orthogonal frequency division multiplexing is illustrated. The core of this method is represented by a novel algorithm for detecting multiple superimposed two-dimensional complex tones in the presence of noise and estimating their parameters. This algorithm is based on a maximum likelihood approach and combines a single tone estimator with a serial cancellation procedure. Our numerical results lead to the conclusion that the developed method can achieve a substantially better accuracy-complexity trade-off than various related techniques in the presence of closely spaced targets

Deterministic Signal Processing Techniques for OFDM-Based Radar Sensing: An Overview

In this manuscript, we analyze the most relevant classes of deterministic signal processing methods currently available for the detection and the estimation of multiple targets in a joint communication and sensing system employing orthogonal frequency division multiplexing. Our objective is offering a fair comparison of the available technical options in terms of required computational complexity and accuracy in both range and Doppler estimation. Our numerical results, obtained in various scenarios, evidence that distinct algorithms can achieve a substantially different accuracy-complexity trade-off

study of fatty acid synthase and adiponectin snps in the italian duroc breed

AbstractFatty acid synthase (FASN) is a multifunctional enzyme that plays a central role in fatty acid biosynthesis catalysing the conversion of acetyl-CoA and malonyl-CoA into long-chain saturated fatty acids and has an important role in energy homeostasis. Pig FASN gene has been assigned to chromosome 12p1.5 and a T>C polymorphism in the fourth exon was found. Adiponectin (ADN) is a fat-derived hormone involved in insulin sensitivity, in lipid and glucose metabolism. In literature is reported that the gene was mapped on chromosome 13 at 53.6 cM, in a region containing QTL for intramuscolar fat (IMF). In this gene several SNPs were identified and one of these polymorphisms (a G>A missense mutation within the 60th codon) determining the Val-Ile substitution in the protein, has been previously reported.The aim of this work is to analyse the variability of polymorphisms of fatty acid synthase described by Munoz et al., 2003 (Anim. Genet. 34:234) and adiponectin genes, candidates for meat and carcass quality..

Identification of differentially expressed small RNAs and prediction of target genes in Italian Large White pigs with divergent backfat deposition

The identification of the molecular mechanisms regulating pathways associated with the potential for fat deposition in pigs can lead to the detection of key genes and markers for the genetic improvement of fat traits. Interactions of microRNAs (miRNAs) with target RNAs regulate gene expression and modulate pathway activation in cells and tissues. In pigs, miRNA discovery is far from saturation, and the knowledge of miRNA expression in backfat tissue and particularly of the impact of miRNA variations is still fragmentary. Using RNA-seq, we characterized the small RNA (sRNA) expression profiles in Italian Large White pig backfat tissue. Comparing two groups of pigs divergent for backfat deposition, we detected 31 significant differentially expressed (DE) sRNAs: 14 up-regulated (including ssc-miR-132, ssc-miR-146b, ssc-miR-221-5p, ssc-miR-365-5p and the moRNA ssc-moR-21-5p) and 17 down-regulated (including ssc-miR-136, ssc-miR-195, ssc-miR-199a-5p and ssc-miR-335). To understand the biological impact of the observed miRNA expression variations, we used the expression correlation of DE miRNA target transcripts expressed in the same samples to define a regulatory network of 193 interactions between DE miRNAs and 40 DE target transcripts showing opposite expression profiles and being involved in specific pathways. Several miRNAs and mRNAs in the network were found to be expressed from backfat-related pig QTL. These results are informative for the complex mechanisms influencing fat traits, shed light on a new aspect of the genetic regulation of fat deposition in pigs and facilitate the prospective implementation of innovative strategies of pig genetic improvement based on genomic markers

Novel Deterministic Detection and Estimation Algorithms for Colocated Multiple-Input Multiple-Output Radars

In this manuscript, the problem of detecting multiple targets and estimating their spatial coordinates (namely, their range and the direction of arrival of their electromagnetic echoes) in a colocated multiple-input multiple-output radar system operating in a static or slowly changing two-dimensional or three-dimensional propagation scenario is investigated. Various solutions, collectively called range & angle serial cancellation algorithms, are developed for both frequency modulated continuous wave radars and stepped frequency continuous wave radars. Moreover, specific technical problems experienced in their implementation are discussed. Finally, the accuracy achieved by these algorithms in the presence of multiple targets is assessed on the basis of both synthetically generated data and of the measurements acquired through three different multiple-input multiple-output radars and is compared with that provided by other methods based on multidimensional Fourier analysis and multiple signal classification

Muscle transcriptome analysis identifies genes involved in ciliogenesis and the molecular cascade associated with intramuscular fat content in Large White heavy pigs

Intramuscular fat content (IMF) is a complex trait influencing the technological and sensorial features of meat products and determining pork quality. Thus, we aimed at analyzing through RNA-sequencing the Semimembranosus muscle transcriptome of Italian Large White pigs to study the gene networks associated with IMF deposition. Two groups of samples were used; each one was composed of six unrelated pigs with extreme and divergent IMF content (0.67 \ub1 0.09% in low IMF vs. 6.81 \ub1 1.17% in high IMF groups) that were chosen from 950 purebred individuals. Paired-end RNA sequences were aligned to Sus scrofa genome assembly 11.1 and gene counts were analyzed using WGCNA and DeSeq2 packages in R environment. Interestingly, among the 58 differentially expressed genes (DEGs), several were related to primary cilia organelles (such as Lebercilin 5 gene), in addition to the genes involved in the regulation of cell differentiation, in the control of RNA-processing, and G-protein and ERK signaling pathways. Together with cilia-related genes, we also found in high IMF pigs an over-expression of the Fibroblast Growth Factor 2 (FGF2) gene, which in other animal species was found to be a regulator of ciliogenesis. Four WGCNA gene modules resulted significantly associated with IMF deposition: grey60 (P = 0.003), darkturquoise (P = 0.022), skyblue1 (P = 0.022), and lavenderblush3 (P = 0.030). The genes in the significant modules confirmed the results obtained for the DEGs, and the analysis with "cyto- Hubba" indicated genes controlling RNA splicing and cell differentiation as hub genes. Among the complex molecular processes affecting muscle fat depots, genes involved in primary cilia may have an important role, and the transcriptional reprogramming observed in high IMF pigs may be related to an FGF-related molecular cascade and to ciliogenesis, which in the literature have been associated with fibro-adipogenic precursor differentiation