Electron spin resonance study of puff-resolved free radical formation in mainstream cigarette smoke

Puff-by-puff resolved gas phase free radicals were measured in mainstream smoke from Kentucky 2R4F reference cigarettes using ESR spectroscopy. Three spin-trapping reagents were evaluated: PBN, DMPO and DEPMPO. Two procedures were used to collect gas phase smoke on a puff-resolved basis: i) the accumulative mode, in which all the gas phase smoke up to a particular puff was bubbled into the trap (i.e., the 5th puff corresponded to the total smoke from the 1st to 5th puffs). In this case, after a specified puff, an aliquot of the spin trap was taken and analysed; or, ii) the individual mode, in which the spin trap was analysed and then replaced after each puff. Spin concentrations were determined by double-integration of the first derivative of the ESR signal. This was compared with the integrals of known standards using the TEMPO free radical. The radicals trapped with PBN were mainly carbon-centred, whilst the oxygen-centred radicals were identified with DMPO and DEPMPO. With each spin trap, the puff-resolved radical concentrations showed a characteristic pattern as a function of the puff number. Based on the spin concentrations, the DMPO and DEPMPO spin traps showed better trapping efficiencies than PBN. The implication for gas phase free radical analysis is that a range of different spin traps should be used to probe complex free radical reactions in cigarette smoke

Stochastic Analysis on RAID Reliability for Solid-State Drives

Solid-state drives (SSDs) have been widely deployed in desktops and data centers. However, SSDs suffer from bit errors, and the bit error rate is time dependent since it increases as an SSD wears down. Traditional storage systems mainly use parity-based RAID to provide reliability guarantees by striping redundancy across multiple devices, but the effectiveness of RAID in SSDs remains debatable as parity updates aggravate the wearing and bit error rates of SSDs. In particular, an open problem is that how different parity distributions over multiple devices, such as the even distribution suggested by conventional wisdom, or uneven distributions proposed in recent RAID schemes for SSDs, may influence the reliability of an SSD RAID array. To address this fundamental problem, we propose the first analytical model to quantify the reliability dynamics of an SSD RAID array. Specifically, we develop a "non-homogeneous" continuous time Markov chain model, and derive the transient reliability solution. We validate our model via trace-driven simulations and conduct numerical analysis to provide insights into the reliability dynamics of SSD RAID arrays under different parity distributions and subject to different bit error rates and array configurations. Designers can use our model to decide the appropriate parity distribution based on their reliability requirements.Comment: 12 page

Advancing Transparency and Impact of Research: Initiating Crosstalk between Indigenous Research and Mainstream “Open Science”

To answer questions about human psychology, psychological science needs to yield credible findings. Because of their goals of understanding people’s lived experiences and advocating for the needs of the Native communities, Indigenous scholars tend to use community-based participatory research (CBPR) or approach science from a constructivist framework. The primary goal of mainstream psychological science is to uncover generalizable facts about human functioning. Approached from a postpositivist framework, mainstream psychological scholars tend to assume the possibility of identifying researcher biases and achieving objective science. Recently, many psychological findings failed to replicate in new samples. The replication crisis has raised concerns about the validity of psychological science. Mainstream open science practices have been promoted as a solution to the replication crisis; the movement encourages researchers to emphasize transparency and accountability to the broad scientific community. The notion of transparency aligns with the principles of CBPR—approach common in Indigenous research. Yet, open science practices are not widely adopted in Indigenous research, and mainstream open science does not emphasize researchers’ accountability to the communities that their science is intended to serve. We examined Indigenous researchers’ awareness and concerns about mainstream open science. Participants endorsed the value of being transparent in the knowledge-production process with the participants and their communities. They also were concerned about being disadvantaged, and the possible negative impact of data sharing on the Native communities. We suggest that there is value in connecting mainstream open science and Indigenous research to advance science that empowers people and makes positive community impact

A Neuroanatomical Signature for Schizophrenia Across Different Ethnic Groups

Schizophrenia is a disabling clinical syndrome found across the world. While the incidence and clinical expression of this illness are strongly influenced by ethnic factors, it is unclear whether patients from different ethnicities show distinct brain deficits. In this multicentre study, we used structural Magnetic Resonance Imaging to investigate neuroanatomy in 126 patients with first episode schizophrenia who came from 4 ethnically distinct cohorts (White Caucasians, African-Caribbeans, Japanese, and Chinese). Each patient was individually matched with a healthy control of the same ethnicity, gender, and age (±1 year). We report a reduction in the gray matter volume of the right anterior insula in patients relative to controls (P < .05 corrected); this reduction was detected in all 4 ethnic groups despite differences in psychopathology, exposure to antipsychotic medication and image acquisition sequence. This finding provides evidence for a neuroanatomical signature of schizophrenia expressed above and beyond ethnic variations in incidence and clinical expression. In light of the existing literature, implicating the right anterior insula in bipolar disorder, depression, addiction, obsessive-compulsive disorder, and anxiety, we speculate that the neuroanatomical deficit reported here may represent a transdiagnostic feature of Axis I disorders

Scaling in long term data sets of geomagnetic indices and solar wind ϵ as seen by WIND spacecraft

We study scaling in fluctuations of the geomagnetic indices (AE, AU, and AL) that provide a measure of magnetospheric activity and of the ε parameter which is a measure of the solar wind driver. Generalized structure function (GSF) analysis shows that fluctuations exhibit self-similar scaling up to about 1 hour for the AU index and about 2 hours for AL, AE and ε when the most extreme fluctuations over 10 standard deviations are excluded. The scaling exponents of the GSF are found to be similar for the three AE indices, and to differ significantly from that of ε. This is corroborated by direct comparison of their rescaled probability density functions

A sampling method for quantifying the information content of IASI channels

There is a vast amount of information about the atmosphere available from instruments on board satellites. One example is the Infrared Atmospheric Sounding Interferometer (IASI) instrument, which measures radiances emitted from Earth’s atmosphere and surface in 8461 channels. It is difficult to transmit, store, and assimilate such a large amount of data. A practical solution to this has been to select a subset of a few hundred channels based on those that contain the most useful information. Different measures of information content for objective channel selection have been suggested for application to variational data assimilation. These include mutual information and the degrees of freedom for signal. To date, the calculation of these measures of information content has been based on the linear theory that is at the heart of operational variational data assimilation. However, the retrieval of information about the atmosphere from the satellite radiances can be highly nonlinear. Here, a sampling method for calculating the mutual information that is free from assumptions about the linearity of the relationship between the observed radiances and the state variables is examined. It is found that large linearization errors can indeed lead to large discrepancies in the value of mutual information. How this new estimate of information content can be used in channel selection is addressed, with particular attention given to the efficiency of the new method. It is anticipated that accounting for the nonlinearity in the channel selection will be beneficial when using nonlinear data assimilation methods currently in development

The Static and Dynamic Lattice Changes Induced by Hydrogen Adsorption on NiAl(110)

Static and dynamic changes induced by adsorption of atomic hydrogen on the NiAl(110) lattice at 130 K have been examined as a function of adsorbate coverage. Adsorbed hydrogen exists in three distinct phases. At low coverages the hydrogen is itinerant because of quantum tunneling between sites and exhibits no observable vibrational modes. Between 0.4 ML and 0.6 ML, substrate mediated interactions produce an ordered superstructure with c(2x2) symmetry, and at higher coverages, hydrogen exists as a disordered lattice gas. This picture of how hydrogen interacts with NiAl(110) is developed from our data and compared to current theoretical predictions.Comment: 36 pages, including 12 figures, 2 tables and 58 reference