1,717 research outputs found
Estimating the Prevalence of a True Oligometastatic Disease.
To delineate a patient group with few distant metastases that could possibly benefit from a curative therapeutic strategy employing a local approach, the term oligometastatic disease (OMD) was introduced into the clinical practice almost 30 years ago [...]
Exoplanet atmospheres with GIANO II. Detection of molecular absorption in the dayside spectrum of HD 102195b
The study of exoplanetary atmospheres is key to understand the differences
between their physical, chemical and dynamical processes. Up to now, the bulk
of atmospheric characterization analysis has been conducted on transiting
planets. On some sufficiently bright targets, high-resolution spectroscopy
(HRS) has also been successfully tested for non-transiting planets. We study
the dayside of the non-transiting planet HD 102195b using the GIANO
spectrograph mounted at TNG, demonstrating the feasibility of atmospheric
characterization measurements and molecular detection for non-transiting
planets with the HRS technique using 4-m class telescopes. The Doppler-shifted
planetary signal changes on the order of many km/s during the observations, in
contrast with the telluric absorption which is stationary in wavelength,
allowing us to remove the contamination from telluric lines while preserving
the features of the planetary spectrum. The emission signal from HD 102195b's
atmosphere is then extracted by cross-correlating the residual spectra with
atmospheric models. We detect molecular absorption from water vapor at
4.4 level. We also find convincing evidence for the presence of
methane, which is detected at the 4.1 level. The two molecules are
detected with a combined significance of 5.3, at a semi-amplitude of
the planet radial velocity km/s. We estimate a planet true mass
of and orbital inclination between 72.5 and
84.79 (1). Our analysis indicates a non-inverted atmosphere
for HD 102195b, as expected given the relatively low temperature of the planet,
inefficient to keep TiO/VO in gas phase. Moreover, a comparison with
theoretical expectations and chemical model predictions corroborates our
methane detection and suggests that the detected and signatures
could be consistent with a low C/O ratio.Comment: 12 pages, 12 figures, accepted for publication in A&
On the bend number of circular-arc graphs as edge intersection graphs of paths on a grid
Golumbic, Lipshteyn and Stern \cite{Golumbic-epg} proved that every graph can
be represented as the edge intersection graph of paths on a grid (EPG graph),
i.e., one can associate with each vertex of the graph a nontrivial path on a
rectangular grid such that two vertices are adjacent if and only if the
corresponding paths share at least one edge of the grid. For a nonnegative
integer , -EPG graphs are defined as EPG graphs admitting a model in
which each path has at most bends. Circular-arc graphs are intersection
graphs of open arcs of a circle. It is easy to see that every circular-arc
graph is a -EPG graph, by embedding the circle into a rectangle of the
grid. In this paper, we prove that every circular-arc graph is -EPG, and
that there exist circular-arc graphs which are not -EPG. If we restrict
ourselves to rectangular representations (i.e., the union of the paths used in
the model is contained in a rectangle of the grid), we obtain EPR (edge
intersection of path in a rectangle) representations. We may define -EPR
graphs, , the same way as -EPG graphs. Circular-arc graphs are
clearly -EPR graphs and we will show that there exist circular-arc graphs
that are not -EPR graphs. We also show that normal circular-arc graphs are
-EPR graphs and that there exist normal circular-arc graphs that are not
-EPR graphs. Finally, we characterize -EPR graphs by a family of
minimal forbidden induced subgraphs, and show that they form a subclass of
normal Helly circular-arc graphs
Exoplanet atmospheres with GIANO. I. Water in the transmission spectrum of HD 189733b
High-resolution spectroscopy (R 20,000) at near-infrared wavelengths
can be used to investigate the composition, structure, and circulation patterns
of exoplanet atmospheres. However, up to now it has been the exclusive dominion
of the biggest telescope facilities on the ground, due to the large amount of
photons necessary to measure a signal in high-dispersion spectra. Here we show
that spectrographs with a novel design - in particular a large spectral range -
can open exoplanet characterisation to smaller telescope facilities too. We aim
to demonstrate the concept on a series of spectra of the exoplanet HD 189733 b
taken at the Telescopio Nazionale Galileo with the near-infrared spectrograph
GIANO during two transits of the planet. In contrast to absorption in the
Earth's atmosphere (telluric absorption), the planet transmission spectrum
shifts in radial velocity during transit due to the changing orbital motion of
the planet. This allows us to remove the telluric spectrum while preserving the
signal of the exoplanet. The latter is then extracted by cross-correlating the
residual spectra with template models of the planet atmosphere computed through
line-by-line radiative transfer calculations, and containing molecular
absorption lines from water and methane. By combining the signal of many
thousands of planet molecular lines, we confirm the presence of water vapour in
the atmosphere of HD 189733 b at the 5.5- level. This signal was
measured only in the first of the two observing nights. By injecting and
retrieving artificial signals, we show that the non-detection on the second
night is likely due to an inferior quality of the data. The measured strength
of the planet transmission spectrum is fully consistent with past CRIRES
observations at the VLT, excluding a strong variability in the depth of
molecular absorption lines.Comment: 10 pages, 8 figures. Accepted for publication in Astronomy &
Astrophysics. v2 includes language editin
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Self-Injurious Behaviour in SCA17: A New Clinical Observation
Background: Self-injurious behaviour has historically been associated with borderline personality disorder. Nevertheless, over recent years, it has been reported in numerous neurological syndromes, especially hyperkinesias.
Case report: Two cases of SCA17 manifested self-injurious behaviour, namely repetitive scratching of the skin resulting in severe excoriations. In one of them, the abnormal behaviour was associated with the inability to resist the impulse to commit the act along with relief following the damage.
Discussion: This is the first report describing self-injurious behaviour in SCA17, but the mechanisms underlying it are still not clear. Further studies are needed to clarify the pathophysiology of such manifestation in hyperkinetic syndromes
Limits on the use of cobalt sulfide as anode of p-type dye-sensitized solar cells
Thin films of cobalt sulfide (CoS) of thickness l < 10m have been employed as anodes of p-type dye-sensitized solar cells (p-DSCs) when P1-sensitized nickel oxide (NiO) was the photoactive cathode and /I - constituted the redox mediator. In the role of counter electrode for p-DSCs, CoS was preferred over traditional platinized fluorine-doped indium oxide (Pt-FTO) due to the lower cost of the starting materials (Co salts) and the easier procedure of deposition onto large area substrates. The latter process was carried out via direct precipitation of CoS from aqueous solutions. The photoconversion efficiency (η) of the corresponding device was 0.07%. This value is about 35% less than the efficiency that is obtained with the analogous p-DSC employing the Pt-FTO anode (η = 0.11). Unlike p-DSCs based on Pt-FTO anodes, the photoelectrochemical cells employing CoS electrodes showed that this anodic material was not able to sustain the photocurrent densities generated by P1-sensitized NiO at a given photopotential. Illumination of the p-DSCs with CoS anodes and P1-sensitized NiO cathodes actually induced the reverse bias of the photoelectrochemical cell with CoS behaving like a p-type semiconductor with no degeneracy. © 2017 IOP Publishing Ltd
Molecular Investigations of PenA-mediated β-lactam Resistance in Burkholderia pseudomallei
Burkholderia pseudomallei is the etiological agent of melioidosis. Because of the bacterium’s intrinsic resistance and propensity to establish latent infections, melioidosis therapy is complicated and prolonged. Newer generation β-lactams, specifically ceftazidime, are used for acute phase therapy, but resistance to this cephalosporin has been observed. The chromosomally encoded penA gene encodes a putative twin arginine translocase (TAT)-secreted β-lactamase, and penA mutations have been implicated in ceftazidime resistance in clinical isolates. However, the role of PenA in resistance has not yet been systematically studied in isogenetic B. pseudomallei mutant backgrounds. We investigated the effects of penA deletion, point mutations, and up-regulation, as well as tat operon deletion and PenA TAT-signal sequence mutations. These experiments were made possible by employing a B. pseudomallei strain that is excluded from Select Agent regulations. Deletion of penA significantly (>4-fold) reduced the susceptibility to six of the nine β-lactams tested and ≥16-fold for ampicillin, amoxicillin, and carbenicillin. Overexpression of penA by single-copy, chromosomal expression of the gene under control of the inducible Ptac promoter, increased resistance levels for all β-lactams tested 2- to 10-fold. Recreation of the C69Y and P167S PenA amino acid substitutions previously observed in resistant clinical isolates increased resistance to ceftazidime by ≥85- and 5- to 8-fold, respectively. Similarly, a S72F substitution resulted in a 4-fold increase in resistance to amoxicillin and clavulanic acid. Susceptibility assays with PenA TAT-signal sequence and ΔtatABC mutants, as well as Western blot analysis, confirmed that PenA is a TAT secreted enzyme and not periplasmic but associated with the spheroplastic cell fraction. Lastly, we determined that two LysR-family regulators encoded by genes adjacent to penA do not play a role in transcriptional regulation of penA expression
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